R.D. Jolly was project leader who conceived and managed the research and was principally responsible for writing. N.R. Marshall was responsible for management and clinical procedures involving the experimental dogs. A. Hartman was the radiologist who managed and interpreted the CT scans. K.M. Hemsley and L.K. Winner were responsible for the assays of SGSH enzyme. J. Marshall performed the statistical analyses.
Intracisternal enzyme replacement therapy in lysosomal storage diseases: dispersal pathways, regional enzyme concentrations and the effect of posttreatment posture
Version of Record online: 9 SEP 2013
© 2012 Massey University. Neuropathology and Applied Neurobiology © 2012 British Neuropathological Society
Neuropathology and Applied Neurobiology
Volume 39, Issue 6, pages 681–692, October 2013
How to Cite
Jolly, R. D., Marshall, N. R., Marshall, J., Hartman, A., Hemsley, K. M. and Winner, L. K. (2013), Intracisternal enzyme replacement therapy in lysosomal storage diseases: dispersal pathways, regional enzyme concentrations and the effect of posttreatment posture. Neuropathology and Applied Neurobiology, 39: 681–692. doi: 10.1111/nan.12010
- Issue online: 9 SEP 2013
- Version of Record online: 9 SEP 2013
- Accepted manuscript online: 17 DEC 2012 08:54PM EST
- Manuscript Accepted: 10 DEC 2012
- Manuscript Received: 8 JUL 2012
- The Society for Mucopolysaccharide Diseases
- Lysosomal Storage Diseases New Zealand
- Palmerston North Medical Research Foundation
- Shire Human Genetic Therapies
Video S1. Time-lapse images of contrast medium in the fourth ventricle, lateral recesses and splenial sulci show a pulsation effect. This was due to variable sizes of these compartments being imaged at different stages of the natural pulsation of the brain (90–100/min), which were out of phase with the 1-s intervals at which images were recorded. The video is at twice the speed at which images were recorded.
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