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Additional Supporting Information may be found in the online version of this article at the publisher's web-site:

Figure S1. Overview of neuropathological alterations. Upper panel: Staining properties of the granular material accumulating in the perivascular space: they are visible in Sudan Black staining (left) and less in Luxol staining (middle image), and they show autofluorescence (right image). Scale bar in the left image represents 0.03 mm. Lower panel: Overview of the tau pathology in the limbic system using immunohistochemistry for AT8 and for RD4. Upper three images represent tau pathology in the amygdala seen at different magnifications (scale bar in the left image represents 2 mm, 0.6 mm and 0.1 mm, from left to right respectively). Middle three images represent tau pathology in the ambient gyrus and hippocampus (scale bar in the left image represents 0.4 mm, 0.6 mm and 0.2 mm, from left to right respectively). Lower three images represent RD4 pathology in the amygdala and entorhinal cortex (scale bar in the left image represents 0.15 mm, 0.15 mm and 0.03 mm, from left to right respectively).

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