These authors contributed equally to the study.
Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity
Article first published online: 21 JAN 2014
© 2013 British Neuropathological Society
Neuropathology and Applied Neurobiology
Volume 40, Issue 2, pages 205–216, February 2014
How to Cite
Baumgarten, P., Harter, P. N., Tönjes, M., Capper, D., Blank, A.-E., Sahm, F., von Deimling, A., Kolluru, V., Schwamb, B., Rabenhorst, U., Starzetz, T., Kögel, D., Rieker, R. J., Plate, K. H., Ohgaki, H., Radlwimmer, B., Zörnig, M. and Mittelbronn, M. (2014), Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity. Neuropathology and Applied Neurobiology, 40: 205–216. doi: 10.1111/nan.12088
- Issue published online: 21 JAN 2014
- Article first published online: 21 JAN 2014
- Accepted manuscript online: 3 OCT 2013 09:57AM EST
- Manuscript Accepted: 3 OCT 2013
- Manuscript Revised: 2 SEP 2013
- Manuscript Received: 6 JUL 2013
Material and Methods.
Figure S1. Immunoblotting analysis confirms the specificity of the anti-FUBP1 antibody.
Figure S2. FUBP1 protein expression is strongest in neurones of the normal human CNS. FUBP1 immunohistochemical analysis of (A) normal human cortex (black arrows, pyramidal neurones; green arrows, clusters of glial cells; red arrow, small capillary; with original magnification ×20) and (B) transition from grey to white matter (red asterisk, grey matter; black asterisk, white matter; original magnification ×10).
Figure S3. FUBP1 is overexpressed in glial cells upon neoplastic transformation. mRNA expression analysis results of FUBP1 from the REMBRANDT database containing microarray data for the probes from the Affymetrix U133 Plus 2.0 GeneChip (accessed 6 February 2012) are shown.
Figure S4. FUBP1 deficiency leads to increased apoptosis sensitivity and decreased proliferation in LNT229 and U138-MG.
Figure 5. FUBP1 expression is not associated with patient survival.