Review: The genetics of Alzheimer's disease; putting flesh on the bones
Version of Record online: 21 JAN 2014
© 2013 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.
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Neuropathology and Applied Neurobiology
Volume 40, Issue 2, pages 97–105, February 2014
How to Cite
Medway, C. and Morgan, K. (2014), Review: The genetics of Alzheimer's disease; putting flesh on the bones. Neuropathology and Applied Neurobiology, 40: 97–105. doi: 10.1111/nan.12101
- Issue online: 21 JAN 2014
- Version of Record online: 21 JAN 2014
- Accepted manuscript online: 3 DEC 2013 02:25AM EST
- Manuscript Accepted: 21 NOV 2013
- Manuscript Received: 29 OCT 2013
For two decades the search for genes involved in Alzheimer's disease brought little reward; it was not until the advent of genome-wide association studies (GWAS) that genetic associations started to be revealed. Since 2009 increasingly large GWAS have revealed 20 loci, which in itself is a substantial increase in our understanding, but perhaps the more important feature is that these studies have highlighted novel pathways that are potentially involved in the disease process. This commentary assembles our latest knowledge while acknowledging that the casual functional variants, and undoubtedly, other genes are still yet to be discovered. This is the challenge that remains and the promise of next-generation sequencing is anticipated as there are a number of large initiatives which themselves should start to yield information before long.