Tumour necrosis factor receptor superfamily member 9 (TNFRSF9) is up-regulated in reactive astrocytes in human gliomas
Article first published online: 29 JAN 2015
© 2014 British Neuropathological Society
Neuropathology and Applied Neurobiology
Volume 41, Issue 2, pages e56–e67, February 2015
How to Cite
Blank, A.-E., Baumgarten, P., Zeiner, P., Zachskorn, C., Löffler, C., Schittenhelm, J., Czupalla, C. J., Capper, D., Plate, K. H., Harter, P. N. and Mittelbronn, M. (2015), Tumour necrosis factor receptor superfamily member 9 (TNFRSF9) is up-regulated in reactive astrocytes in human gliomas. Neuropathology and Applied Neurobiology, 41: e56–e67. doi: 10.1111/nan.12135
- Issue published online: 29 JAN 2015
- Article first published online: 29 JAN 2015
- Accepted manuscript online: 10 MAR 2014 12:17AM EST
- Manuscript Accepted: 4 MAR 2014
- Manuscript Received: 10 OCT 2013
Figure S1. TNFRSF9 expression in primary non-diffuse tumours and malformations. Haematoxylin and eosin (HE) stainings (left A–D) and immunohistochemistry for TNFRSF9 (middle A–D and C–D right) as well as for BRAF V600E (right A) and phosphoS6 (right B) in (A) a pleomorphic xanthoastrocytoma (PXA), (B) subependymal giant cell astrocytoma (SEGA), (C) focal cortical dysplasia (FCD) and (D) ganglioglioma. (Scale bars: 200 μm in A–B; 100 μm in C–D left and middle; 50 μm in C–D right.)
Figure S2. TNFRSF9 expression is associated with reactive astrogliosis also in non-neoplastic CNS lesions. HE stainings (left A–E) and immunohistochemistry for TNFRSF9 (middle A–E) of (A) ischemic stroke (tissue surrounding a pseudocyst of an old infarction > 6 months), (B) cavernoma, (C) an acute demyelinating encephalomyelitis (ADEM), (D) CNS tissue surrounding a CNS lymphoma and (E) foetal CNS tissue suffering from intrauterine hypoxia (subventricular zone) are depicted. (Scale bars: 50 μm in A right, C left and right, D right, E middle and right; 100 μm in A left and middle, B right, C middle, D left and middle and E left; 200 μm in B left and middle.)
Table S1. Patient data of neoplastic and non-neoplastic CNS lesions.
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