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Figure S1. Quantification of macrophage/microglia inflammation.

Figure S2. Cortical lesion types.

Figure S3. Lymphocytic inflammation in MS cases and controls.

Figure S4. Microglia/macrophage inflammation in MS cases and controls.

Table S1. Antibodies for immunohistochemistry.

Table S2. Patient demographics (All MS cases).

Table S3. Patient demographics (MS cases with age <62).

Table S4. Patient demographics (MS cases with age >62).

Appendix S1. The influence of HLA-DRB1*15 on correlations between motor cortical and spinal cord demyelination.

Appendix S2a. The influence of HLA-DRB1*15 on correlations between motor cortical NAGM and spinal cord NAGM T-cell inflammation.

Appendix S2b. The influence of HLA-DRB1*15 on correlations between motor cortical NAGM and spinal cord NAWM T-cell inflammation.

Appendix S3a. The influence of HLA-DRB1*15 on correlations between motor cortical NAGM and spinal cord NAGM CD68+ microglia/macrophage inflammation.

Appendix S3b. The influence of HLA-DRB1*15 on correlations between motor cortical NAGM and spinal cord NAWM CD68+ microglia/macrophage inflammation.

Appendix S4. The influence of HLA-DRB1*15 on correlations between motor cortical and spinal cord meningeal inflammation.

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