Neuropathology and Applied Neurobiology

© British Neuropathological Society

Cover image for Vol. 43 Issue 3

April 2017

Volume 43, Issue 3

Pages 187–276

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. In this Issue
    4. Editorial
    5. Review
    6. Original Articles
    7. Scientific correspondence
    1. Issue Information (page 187)

      Version of Record online: 10 APR 2017 | DOI: 10.1111/nan.12351

  2. In this Issue

    1. Top of page
    2. Issue Information
    3. In this Issue
    4. Editorial
    5. Review
    6. Original Articles
    7. Scientific correspondence
    1. In This Issue (pages 189–190)

      Version of Record online: 10 APR 2017 | DOI: 10.1111/nan.12398

  3. Editorial

    1. Top of page
    2. Issue Information
    3. In this Issue
    4. Editorial
    5. Review
    6. Original Articles
    7. Scientific correspondence
    1. You have free access to this content
      Globular glial inclusions unveil enigmas of MAPT mutations (pages 191–193)

      G. G. Kovacs

      Version of Record online: 10 APR 2017 | DOI: 10.1111/nan.12372

      The editorial by Professor Kovacs provides an overview of tauopathies, setting the scene for the publication in this issue by Tacik and colleagues, of the first case of globular glial tauopathy (GGT) in association with p.P301L mutation in MAPT.

  4. Review

    1. Top of page
    2. Issue Information
    3. In this Issue
    4. Editorial
    5. Review
    6. Original Articles
    7. Scientific correspondence
    1. You have free access to this content
      Review: Tau in biofluids – relation to pathology, imaging and clinical features (pages 194–199)

      H. Zetterberg

      Version of Record online: 10 APR 2017 | DOI: 10.1111/nan.12378

      The search for reliable biomarkers for neurodegenerative diseases is an active field, important for diagnosis, monitoring disease progression and treatment response. This focussed review by Professor Zetterberg considers the association of total tau and phospho-tau in body fluids with neuropathology, imaging and clinical features in Alzheimer's disease (AD) and other neurodegenerative diseases.

  5. Original Articles

    1. Top of page
    2. Issue Information
    3. In this Issue
    4. Editorial
    5. Review
    6. Original Articles
    7. Scientific correspondence
    1. Clinicopathologic heterogeneity in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) due to microtubule-associated protein tau (MAPT) p.P301L mutation, including a patient with globular glial tauopathy (pages 200–214)

      P. Tacik, M. Sanchez-Contreras, M. DeTure, M. E. Murray, R. Rademakers, O. A. Ross, Z. K. Wszolek, J. E. Parisi, D. S. Knopman, R. C. Petersen and D. W. Dickson

      Version of Record online: 8 MAR 2017 | DOI: 10.1111/nan.12367

      Thumbnail image of graphical abstract

      This paper describes one of the largest series of p.P301L MAPT mutation cases published to date and is the first time that GGT, until recently considered to be sporadic, has been associated with this mutation.

    2. Altered trafficking of abnormal prion protein in atypical scrapie: prion protein accumulation in oligodendroglial inner mesaxons (pages 215–226)

      M. Jeffrey, L. González, M. M Simmons, N. Hunter, S. Martin and G. McGovern

      Version of Record online: 24 MAR 2016 | DOI: 10.1111/nan.12302

      Thumbnail image of graphical abstract

      This study of atypical scrapie examines the sub-cellular distribution of disease-associated prion protein (PrPd) and membrane changes, contrasting these with classical prion diseases. The importance of the study is the indication that trafficking of abnormal PrP is influenced by an interaction of agent strain and host genotype.

    3. Axonal motor protein KIF5A and associated cargo deficits in multiple sclerosis lesional and normal-appearing white matter (pages 227–241)

      K. Hares, J. Redondo, K. Kemp, C. Rice, N. Scolding and A. Wilkins

      Version of Record online: 1 APR 2016 | DOI: 10.1111/nan.12305

      Thumbnail image of graphical abstract

      Investigation of KIF5A, a mediator of anterograde protein transport, in multiple sclerosis indicates that axonal transport deficits may contribute to neuronal degeneration and that this may be influenced by genotype.

    4. Sudan black: a fast, easy and non-toxic method to assess myelin repair in demyelinating diseases (pages 242–251)

      Benjamin V. Ineichen, Oliver Weinmann, Nicolas Good, Patricia S. Plattner, Carla Wicki, Elisabeth J. Rushing, Michael Linnebank and Martin E. Schwab

      Version of Record online: 10 MAR 2017 | DOI: 10.1111/nan.12373

      Thumbnail image of graphical abstract

      Therapeutic intervention to promote remyelination is a priority target in multiple sclerosis (MS) necessitating high throughput screening of candidate drugs. This study identifies Sudan black staining of cryosections as a suitable non-toxic, rapid and economical screening method capable of detecting myelin repair in human spinal cord and a rat model.

    5. MET immunolabelling is a useful predictive tool for MET gene amplification in glioblastoma (pages 252–266)

      F. Burel-Vandenbos, M. Ngo-Mai, B. Dadone, I. Di Mauro, S. Gimet, E. Saada-Bouzid, V. Bourg, F. Almairac, D. Fontaine, T. Virolle and F. Pedeutour

      Version of Record online: 4 APR 2016 | DOI: 10.1111/nan.12320

      Thumbnail image of graphical abstract

      The rare occurrence of MET amplification in glioblastomas represents a therapeutic target. In this study strong immunohistochemical labelling of MET was found to be associated with gene amplification and is, therefore, proposed as a screening tool to direct molecular investigation of glioblastomas.

  6. Scientific correspondence

    1. Top of page
    2. Issue Information
    3. In this Issue
    4. Editorial
    5. Review
    6. Original Articles
    7. Scientific correspondence
    1. Medulloblastoma with extensive nodularity: a tumour exclusively of infancy? (pages 267–270)

      Marco Gessi, Tobias Goschzik, Evelyn Dörner, Kathrin Söldner, Christine Schupp and Torsten Pietsch

      Version of Record online: 28 APR 2016 | DOI: 10.1111/nan.12322

    2. You have free access to this content
      K27M mutation in H3F3A in ganglioglioma grade I with spontaneous malignant transformation extends the histopathological spectrum of the histone H3 oncogenic pathway (pages 271–276)

      N. Joyon, A. Tauziède-Espariat, A. Alentorn, M. Giry, D. Castel, L. Capelle, M. Zanello, P. Varlet and F. Bielle

      Version of Record online: 10 APR 2017 | DOI: 10.1111/nan.12329

SEARCH

SEARCH BY CITATION