Analysis of parkinsonian tremor and rigidity relying on peripheral and central intensifying mechanisms through thalamic activities
Version of Record online: 2 APR 2014
© 2014 Japanese Society of Neurology and Wiley Publishing Asia Pty Ltd
Neurology and Clinical Neuroscience
Volume 2, Issue 2, pages 28–37, March 2014
How to Cite
Narabayashi, Y. and Oshima, T. (2014), Analysis of parkinsonian tremor and rigidity relying on peripheral and central intensifying mechanisms through thalamic activities. Neurology & Clinical Neurosc, 2: 28–37. doi: 10.1111/ncn3.77
- Issue online: 11 JUL 2014
- Version of Record online: 2 APR 2014
- Accepted manuscript online: 17 FEB 2014 12:00AM EST
- Manuscript Accepted: 8 FEB 2014
- 13 to 27-Hz activities;
- 3 to 7-Hz activities;
- parkinsonian tremor;
Background and Aim
Passive and active muscle manipulations modify parkinsonian tremor and rigidity. We hypothesized that these outer maneuvers provoke thalamic 3 to 7-Hz (τ-range) and 13 to 27-Hz (β-band) activities, which in turn act to develop and maintain the symptoms. To test the hypothesis, we examined the temporal and quantitative relationships of the thalamic activities with the symptoms in conditions under the outer maneuvers.
In thalamotomy for 20 patients with Parkinson's disease, we monitored thalamic local field potentials and multiple unit spikes with surface electromyograms of neck and limb muscles.
Tremor is intensified in postural and kinetic modes with higher amplitude and faster frequency than the resting state, and in tremor rhythms on the cogwheel rigidity with accelerated muscle tone. Exaggerated thalamic τ-range activities always led to tremor of those intensified modes. The τ-range activities developed and maintained tremor in keeping a quantitative relationship in amplitude. Both the passive and active muscle manipulations transiently abolished the β-band activities, and then made them relapse to lead to rigidity in a waning and waxing fashion. Because of these changes of β-band activities, the patient's active effort to move or hold postures caused a state in conflict between voluntary and involuntary contractions.
Together, the results suggest that passively activated peripheral kinesthetic afferents, and actively triggered central motor initiatives act to develop and maintain tremor and rigidity through the thalamic motor nuclei as the crucial relay stations.