The authors declared no conflict of interest and received no financial support.
The role of cytokines in the pathogenesis of systemic lupus erythematosus – from bench to bedside
Article first published online: 27 MAR 2013
© 2013 The Authors. Nephrology © 2013 Asian Pacific Society of Nephrology
Volume 18, Issue 4, pages 243–255, April 2013
How to Cite
Yap, D. Y. H. and Lai, K. N. (2013), The role of cytokines in the pathogenesis of systemic lupus erythematosus – from bench to bedside. Nephrology, 18: 243–255. doi: 10.1111/nep.12047
- Issue published online: 27 MAR 2013
- Article first published online: 27 MAR 2013
- Accepted manuscript online: 4 MAR 2013 04:35AM EST
- Manuscript Accepted: 10 FEB 2013
- systemic lupus erythematosus
The pathogenesis of systemic lupus erythematosus (SLE) entails a complex interaction between the different arms of the immune system. While autoantibodies production and immune complex deposition are cornered as hallmark features of SLE, there is growing evidence to propose the pathogenic role of cytokines in this disease. Examples of these cytokines include BLys, interleukin-6, interleukin-17, interleukin-18, type I interferons and tumour necrosis factor alpha. These cytokines all assume pivotal functions to orchestrate the differentiation, maturation and activation of various cell types, which would mediate local inflammatory process and tissue injury. The knowledge on these cytokines not only fosters our understanding of the disease, but also provides insights in devising biomarkers and targeted therapies. In this review, we focus on cytokines which have substantial pathogenic significance and also highlight the possible clinical applications of these cytokines.