These authors have contributed equally to this study.
N-acetylgalactosamine exposure of serum IgA1 was associated with glomerulosclerosis and tubular atrophy/interstitial fibrosis of IgA nephropathy patients
Article first published online: 17 DEC 2013
© 2013 Asian Pacific Society of Nephrology
Volume 19, Issue 1, pages 32–39, January 2014
How to Cite
Xu, L.-X., Ye, Z.-m., Feng, Z., Xin, G., Zhang, B., Liu, S., Li, R., Li, Z., Liang, X. and Shi, W. (2014), N-acetylgalactosamine exposure of serum IgA1 was associated with glomerulosclerosis and tubular atrophy/interstitial fibrosis of IgA nephropathy patients. Nephrology, 19: 32–39. doi: 10.1111/nep.12169
Conflicts of Interest
None of the authors has any potential financial conflict of interest related to this manuscript.
- Issue published online: 17 DEC 2013
- Article first published online: 17 DEC 2013
- Accepted manuscript online: 17 OCT 2013 03:32AM EST
- Manuscript Accepted: 10 OCT 2013
- National Nature Science Foundation of China. Grant Number: 81100511
- NSFC of Guangdong province. Grant Number: 845100800400162
- Immunoglobulin A nephropathy;
- renal pathology
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis with various histological and clinical phenotypes. N-acetylgalactosamine (GalNAc) exposure plays a pivotal role in the pathogenesis of IgAN. The aim of the current study is to investigate whether GalNAc exposure of serum IgA1 was associated with clinical and pathological manifestation of IgAN.
Sera from 199 patients with biopsy proved IgAN were collected. Clinical and pathological manifestations were collected. Biotinylated Helix aspersa were used in ELISA to examine GalNAc exposure on IgA1 molecules. Patients were divided into two groups according to the GalNAc exposure rate less or more than 0.4.
Age, gender, and serum creatinine were comparable between the two groups. Univariate analysis showed that significantly higher urinary protein excretion rate but less severe glomerular sclerosis and tubularinterstitial fibrosis were observed in the lower GalNAc exposure group. Multivariate regression analysis demonstrated that adjusted by age and gender, the GalNAc exposure rate more than 0.4 was a risk factor of glomerular sclerosis and tubularinterstitial fibrosis, OR*(95% CI) were 2.76 (1.19–6.37) and 2.49 (1.18–5.25), respectively.
Immunoglobulin A nephropathy patients with lower proteinuria had higher GalNAc exposure rates. The GalNAc exposure rate more than 0.4 was a risk factor of severe chronic renal tissue change.