Nephrology

Cover image for Vol. 17 Issue 2

February 2012

Volume 17, Issue 2

Pages 99–198

  1. REVIEW ARTICLE

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
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      Nephrotoxicity of recreational party drugs (pages 99–103)

      LINDA BERNEY-MEYER, TRACEY PUTT, JOHN SCHOLLUM and ROBERT WALKER

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01537.x

      N-benzylpiperazine (BZP) is a popular recreational party drug. There is a potential for acute kidney injury, and this needs to be considered when any individual presents with symptoms of recreational drug overdose with 3,4-methylenedioxymethamphetamine (MDMA) and/or BZP components.

  2. ACUTE RENAL DISEASE

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. Development of a non-targeted metabolomics method to investigate urine in a rat model of polycystic kidney disease (pages 104–110)

      HAYLEY ABBISS, GARTH L MAKER, JOEL GUMMER, MATTHEW J SHARMAN, JACQUELINE K PHILLIPS, MARY BOYCE and ROBERT D TRENGOVE

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01532.x

      This paper reports on a method for non-targeted metabolite profiling of rat urine, using the approach to investigate the cystic phenotype of the Lewis polycystic kidney rat. The findings of this study demonstrate the potential of metabolomics to investigate kidney disease.

    2. Hyperglycaemia emerging during general anaesthesia induces rat acute kidney injury via impaired microcirculation, augmented apoptosis and inhibited cell proliferation (pages 111–122)

      SHAI EFRATI, SYLVIA BERMAN, RAMZIA ABU HAMAD, YARIV SIMAN-TOV, MICHAEL CHANIMOV and JOSHUA WEISSGARTEN

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01538.x

      This experimental study investigated the role of hyperglycaemia emerging during general anaesthesia in induction of acute kidney injury (AKI). Hyperglycaemia may increase the risk of AKI by disturbing intra-renal autoregulation, increasing intra-renal Angiotensin-II and augmenting renal cell apoptosis.

  3. CHRONIC KIDNEY DISEASE

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. Prevalence and risk factors of chronic kidney disease in first-degree relatives of chronic kidney disease patients in Southern China (pages 123–130)

      XIN WEI, ZHIJIAN LI, WEI CHEN, HAIPING MAO, ZHIBIN LI, XIUQING DONG, JIAQING TAN, LI LING, ANG CHEN, NA GUO and XUEQING YU

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01523.x

      By identifying that first degree relatives of people with CKD have a high risk of themselves developing CKD, the authors suggest this group is targeted for CKD screening.

    2. Determination of fluid status in haemodialysis patients with whole body and calf bioimpedance techniques (pages 131–140)

      LI LIU, FANSAN ZHU, JOCHEN G RAIMANN, STEPHAN THIJSSEN, MURAT H SIPAHIOGLU, GREGORY WYSTRYCHOWSKI, THOMAS KITZLER, CIRO TETTA, PETER WABEL, PETER KOTANKO and NATHAN W LEVIN

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01526.x

      The authors used calf bioimpedance spectroscopy (cBIS) and whole body model (WBM) based on whole body impedance to determine dry weight in 21 haemodialysis patients. They showed that WBM could be useful to predict a target range of normal hydration weight particularly for patients with fluid overload and that cBIS provides an accurate reference for the estimation of dry weight. Thus, they concluded that the combined use of cBIS and WBM is promising for estimation of hydration status in haemodialysis patients.

  4. DIALYSIS

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. Blind peritoneal catheter placement with a tenckhoff trocar by nephrologists: A single-center experience (pages 141–147)

      SEOK HUI KANG, JUN YOUNG DO, KYU HYANG CHO, JONG WON PARK and KYUNG WOO YOON

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01518.x

      A retrospective single-centre analysis of outcomes of blind peritoneal catheter insertion in more than 400 patients, supporting its use as an alternative to standard placement.

  5. INTEGRATIVE BIOLOGY

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. The role of autophagy in unilateral ureteral obstruction rat model (pages 148–159)

      WAN-YOUNG KIM, SUN AH NAM, HO CHEOL SONG, JUN SUNG KO, SANG HEE PARK, HONG LIM KIM, EUY JIN CHOI, YONG-SOO KIM, JIN KIM and YONG KYUN KIM

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01541.x

      Autophagy is a mechanism of limited destruction of cellular organelles which protects cells against major stresses. This study provides functional evidence that autophagy protects against tubular damage and interstitial fibrosis in the obstructed kidney. Furthermore, it is proposed that autophagy suppresses cell proliferation in the contralateral kidney, providing a link between autophagy and compensatory hypertrophy.

    2. Circulating anti-glomerular basement membrane autoantibodies against α3(IV)NC1 undetectable by commercially available enzyme-linked immunosorbent assays (pages 160–166)

      XIAO-YU JIA, ZHEN QU, ZHAO CUI, RUI YANG, JUAN ZHAO and MING-HUI ZHAO

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01511.x

      Goodpasture's disease (anti-glomerular basement membrane glomerulonephritis) is characterized by antibodies directed against the non-collagenous domain of the α3 chain of type IV collagen. Commercially available assays for antibodies in the serum are reliable, but do not detect all cases. The epitopes within α3(IV)NC1 are conformational and cryptic. In this paper, Jia et al. show that some patients with Goodpasture's disease possess autoantibodies to α3(IV)NC1 that do not recognize the common epitopes and are not detected by commercial enzyme linked immunosorbent assay, providing some explanation for why a minority of patients with the disease appear to ‘be negative’ for anti-GBM antibodies in the serum.

  6. PATHOLOGY, IMMUNOLOGY & INFLAMMATION

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. Relationships between tumour necrosis factor-α, interleukin-12B and interleukin-10 gene polymorphisms and hepatitis B in Chinese Han haemodialysis patients (pages 167–174)

      CUIYU WANG, XIAOLI ZHANG, BEI ZHU, DALAN HU, JIANQING WU, RONGBIN YU and WEIHONG ZHAO

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01539.x

      HBV infection in patients with maintenance haemodialysis is a challenge for clinicians. Cytokine gene polymorphism is one of the factors for HBV susceptibility and spontaneous clearance. This study demonstrated that TNF-α and IL-12 gene polymorphisms may be associated with HBV susceptibility, while IL-10 gene polymorphisms may be related to HBV persistence infection.

  7. PROGRESSIVE CHRONIC RENAL DISEASE

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. Concomitant presence of endothelial nitric oxide 894T and angiotensin II-converting enzyme D alleles are associated with diabetic nephropathy in a Kurdish population from Western Iran (pages 175–181)

      ZOHREH RAHIMI, ASAD VAISI-RAYGANI, ZIBA RAHIMI and ABBAS PARSIAN

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01533.x

      The identification of genetic markers predicting progression in chronic kidney disease would help tailor treatment and predict renal prognosis. In this issue, a study from Western Iran demonstrates that eNOS T combined with an ACE D allele is associated with an increased risk of macroalbuminuria in type 2 diabetes.

    2. Assessment of markers of glycaemic control in diabetic patients with chronic kidney disease using continuous glucose monitoring (pages 182–188)

      FREDERIEK E VOS, JOHN B SCHOLLUM, CAROLYN V COULTER, PATRICK J MANNING, STEPHEN B DUFFULL and ROBERT J WALKER

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01517.x

      The evaluation of glycaemic control in chronic dialysis patients with diabetes is problematic as traditional markers, such as glycosylated haemoglobin (HbA1c), may underestimate glucose control. In this issue, Vos and colleagues provide new evidence that glycated albumin is a more accurate marker of glycaemic control than HbA1c, in diabetic patients with stage 4 and 5 chronic kidney disease.

    3. Less expression of prohibitin is associated with increased Caspase-3 expression and cell apoptosis in renal interstitial fibrosis rats (pages 189–196)

      TIAN-BIAO ZHOU, YUAN-HAN QIN, CHUN ZHOU, FENG-YING LEI, YAN-JUN ZHAO, JING CHEN, LI-NA SU and WEI-FANG HUANG

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01522.x

      The authors reported a reduced expression of prohibitin and that this is associated with the increased Caspase-3 expression and cell apoptosis in renal interstitial fibrosis rats in a rat UUO model. These findings suggest that prohibitin plays a protective role against renal interstitial fibrosis and regulates the expression of Caspase-3, which induces cell apoptosis in UUO rats. The authors acknowledged the limitation in that they have not performed in vitro experiments to show that the causal effects of prohibitin on cell apoptosis using cultured renal cells cannot be established.

  8. CORRESPONDENCE

    1. Top of page
    2. REVIEW ARTICLE
    3. ACUTE RENAL DISEASE
    4. CHRONIC KIDNEY DISEASE
    5. DIALYSIS
    6. INTEGRATIVE BIOLOGY
    7. PATHOLOGY, IMMUNOLOGY & INFLAMMATION
    8. PROGRESSIVE CHRONIC RENAL DISEASE
    9. CORRESPONDENCE
    1. URETHRAL STRICTURE CAUSED BY SCHISTOSOMIASIS IN A RENAL TRANSPLANT RECIPIENT (pages 197–198)

      Ying Wang, Deshan F Sebaratnam, James CH Wong, Wendy Cooper, Kate R Wyburn and Josette M Eris

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01516.x

    2. CARCINOID TUMOUR MANAGEMENT IN HAEMODIALYSIS: A CASE REPORT (page 198)

      Michael T Burke and Nicholas A Gray

      Version of Record online: 19 JAN 2012 | DOI: 10.1111/j.1440-1797.2011.01519.x

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