Nephrology

Cover image for Vol. 17 Issue 6

August 2012

Volume 17, Issue 6

Pages 525–590

  1. REVIEW ARTICLE

    1. Top of page
    2. REVIEW ARTICLE
    3. EPIDEMIOLOGY
    4. DIALYSIS
    5. HYPERTENSION
    6. TRANSPLANTATION
    7. CORRESPONDENCE
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      Podocyte culture: Tricks of the trade (pages 525–531)

      LAN NI, MOIN SALEEM and PETER W MATHIESON

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01619.x

      Podocyte cell lines are becoming widely used in renal research. This article gives a detailed description of the production and culture of immortalized podocyte cell lines. Furthermore, these methods can be applied to essentially any cell type, providing a practical approach to study the interactions of renal cell types in vitro.

  2. EPIDEMIOLOGY

    1. Top of page
    2. REVIEW ARTICLE
    3. EPIDEMIOLOGY
    4. DIALYSIS
    5. HYPERTENSION
    6. TRANSPLANTATION
    7. CORRESPONDENCE
    1. Impact of metabolic syndrome on the incidence of chronic kidney disease: A Chinese cohort study (pages 532–538)

      TSAN YANG, CHI-HONG CHU, CHIH-HSUNG HSU, PO-CHIEN HSIEH, TIEH-CHI CHUNG, CHYI-HUEY BAI, SAN-LIN YOU, LEE-CHING HWANG, CHIH-MING LIN and CHIEN-AN SUN

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01607.x

      A longitudinal cohort study investigating the association between the metabolic syndrome and incident CKD in a Chinese population. The presence of the metabolic syndrome was associated with s significant risk of developing CKD (HR 1.42 95% CI 1.03–1.73).

    2. Nationwide survey of adolescents and young adults with end-stage kidney disease (pages 539–544)

      ANGUS G RITCHIE, PHILIP A CLAYTON, FIONA E MACKIE and SEAN E KENNEDY

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01610.x

      This manuscript presents country-specific data that will inform discussions about health-care provision in end-stage kidney disease (ESKD) in the Australian setting. The authors concluded that as the majority of Australian adolescents and young adults (AYA) with ESKD live in the capital cities, there may be an opportunity to establish centralized services designed to cater for the needs of AYA patients.

  3. DIALYSIS

    1. Top of page
    2. REVIEW ARTICLE
    3. EPIDEMIOLOGY
    4. DIALYSIS
    5. HYPERTENSION
    6. TRANSPLANTATION
    7. CORRESPONDENCE
    1. Effect of statins on chronic inflammation and nutrition status in renal dialysis patients: A systematic review and meta-analysis (pages 545–551)

      JIN DENG, QIAOYUAN WU, YUNHUA LIAO, DONGMEI HUO and ZHENHUA YANG

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01597.x

      In this systematic review of randomized controlled trials, the authors show that in dialysis patients, statins affect the chronic inflammation status favourably as reflected by reduction in serum CRP and hs-CRP levels, but do not improve the nutrition status as reflected by serum albumin.

    2. Involvement of parathyroid hormone-related protein in vascular calcification of chronic haemodialysis patients (pages 552–560)

      FANG LIU, PING FU, WENXING FAN, RONG GOU, YOUQUN HUANG, HONGYU QIU, HUI ZHONG and SONGMIN HUANG

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01601.x

      This paper reports elevated expressions of PTHrP and BMP-2/Cbfa1 in calcified vessel walls of patients on haemodialysis. Experimentally, exogenous rhPTHrP-1–34 increased intracellular calcium deposition in aortic smooth muscle cells and activated BMP-2/Cbfa1, with reduction by silencing PTHrP. Therefore PTHrP may be involved in vascular calcification by activating the BMP-2/Cbfa1 signalling pathway.

    3. Factors associated with cerebral white matter hyperintensities in haemodialysis patients (pages 561–568)

      TOSHIHIDE NAGANUMA, YOSHIAKI TAKEMOTO, TETSUO SHOJI, HIDEAKI SHIMA, EIJI ISHIMURA, MIKIO OKAMURA and TATSUYA NAKATANI

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01596.x

      This study demonstrates factors associated with cerebral white matter hyperintensities (WMH) on MRI in a relatively large cohort of HD patients. Among the risk factors that the authors described, female gender is a new finding as a risk factor of WMH.

    4. Patent foramen ovale, dialysis and microembolization (pages 569–574)

      SUDHAKAR GEORGE, STEPHEN HOLT and DAVID HILDICK-SMITH

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01608.x

      This detailed study examined patients undergoing haemodialysis and compared them with a control group receiving peritoneal dialysis. They demonstrated that one in five dialysis patients has a patent foramen ovale, that microemboli are formed in fistulae during dialysis, but did not demonstrate any evidence of cerebral emboli.

  4. HYPERTENSION

    1. Top of page
    2. REVIEW ARTICLE
    3. EPIDEMIOLOGY
    4. DIALYSIS
    5. HYPERTENSION
    6. TRANSPLANTATION
    7. CORRESPONDENCE
    1. Vitamin D deficiency, CD4+CD28null cells and accelerated atherosclerosis in chronic kidney disease (pages 575–581)

      ASHOK KUMAR YADAV, DEBASISH BANERJEE, ANUPAM LAL and VIVEKANAND JHA

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01611.x

      The possible links between vitamin D, immune function and atherosclerosis are explored in this paper. Using intima-media thickness as an index of vascular disease, significant associations were found with low levels of vitamin D, hsCRP and the frequency of T lymphocyte subsets. These findings suggest that the link between vitamin D and vascular disease in chronic renal failure might involve the immune system.

  5. TRANSPLANTATION

    1. Top of page
    2. REVIEW ARTICLE
    3. EPIDEMIOLOGY
    4. DIALYSIS
    5. HYPERTENSION
    6. TRANSPLANTATION
    7. CORRESPONDENCE
    1. Body mass index and postoperative complications in kidney transplant recipients (pages 582–587)

      STEPHANIE ZRIM, TIM FURLONG, BLAIR S GRACE and ANTHONY MEADE

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01621.x

      Obesity is an increasingly common problem in our end-stage kidney disease populations. This paper analysed a retrospective cohort of 508 adult patients who received primary kidney grafts at a single centre. Overall, 62% of transplant recipients had a body mass index (BMI) above 25 kg/m2 at transplant. Higher BMI was associated with an increased risk of wound complications (P < 0.001), early nephrectomy (P = 0.002) and delayed graft function (P = 0.03), but not associated with surgical or urological complications, or intensive care unit admission.

  6. CORRESPONDENCE

    1. Top of page
    2. REVIEW ARTICLE
    3. EPIDEMIOLOGY
    4. DIALYSIS
    5. HYPERTENSION
    6. TRANSPLANTATION
    7. CORRESPONDENCE
    1. ALLOCATING THE UNEXPECTED KIDNEY (pages 588–589)

      Liv Amos, John Kanellis, Shaun Summers, Alan Saunder, Nancy Suh and William Mulley

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01587.x

    2. IMAGING OF DESMOID TUMOR LOCATED IN RENAL HILUM (pages 589–590)

      Jian-Jian Xiang, Ye-Qing Mao, Bai-Sen Cai, Bai-Shu Zhong, Qi-Han You, Yi-Wei Lin, Hong Chen, Bo-Hua Shen and Xiang-Yi Zheng

      Article first published online: 23 JUL 2012 | DOI: 10.1111/j.1440-1797.2012.01582.x

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