Annual decline in estimated glomerular filtration rate is a risk factor for cardiovascular events independent of proteinuria (pages 574–580)
Kei Nagai, Kunihiro Yamagata, Reiko Ohkubo, Chie Saito, Koichi Asahi, Kunitoshi Iseki, Kenjiro Kimura, Toshiki Moriyama, Ichiei Narita, Shouichi Fujimoto, Kazuhiko Tsuruya, Tsuneo Konta, Masahide Kondo and Tsuyoshi Watanabe
Article first published online: 24 AUG 2014 | DOI: 10.1111/nep.12286
Summary at a Glance
Previous studies have shown that annual decline or increment estimated glomerular filtration rate may influence prognosis. This study focuses on the cardiovascular events and demonstrates that the annual decline rate in eGFR is a risk factor for cardiovascular events independent of proteinuria by using a large longitudinal Japanese population-based study of participants receiving annual health checkups from 2008–2010. To reduce the incidence of cardiovascular events in the general population, serial measurement of serum creatinine to obtain the change rate in eGFR is warranted.