Nephrology

Cover image for Vol. 20 Issue 3

March 2015

Volume 20, Issue 3

Pages i–ii, 113–226

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. Issue Information (pages i–ii)

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12417

  2. EDITORIAL

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. Chronic kidney disease in disadvantaged populations (pages 113–116)

      Guillermo Garcia-Garcia, Vivekanand Jha and on behalf of theWorld Kidney Day Steering Committee

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12367

  3. REVIEW ARTICLES

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. You have free access to this content
      Transcutaneous measurement of glomerular filtration rate in small rodents: Through the skin for the win? (pages 117–123)

      Stacey J Ellery, Xiaochu Cai, David D Walker, Hayley Dickinson and Michelle M Kett

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12363

      Summary at a Glance

      This methods in renal research article describes a new non-invasive technique to measure glomerular filtration rate in small animals. Furthermore, this technology has potential for broader use in renal research, such as in measuring the rate of clearance of albumin from the circulation in animals with proteinuria.

    2. You have free access to this content
      Four years of experience with the Australian kidney paired donation programme (pages 124–131)

      Linda Cantwell, Claudia Woodroffe, Rhonda Holdsworth and Paolo Ferrari

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12369

      Summary at a Glance

      This Australian report reviewed the 4-year experience of kidney paired donation programme which provides an alternative source of live donor kidney transplantation.

    3. You have free access to this content
      Study of microRNA in diabetic nephropathy: Isolation, quantification and biological function (pages 132–139)

      Phillip Kantharidis, Shinji Hagiwara, Eoin Brennan and Aaron D. McClelland

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12374

      Summary at a Glance

      The authors are experts in examining the role of microRNAs in kidney disease. In this invited review, the authors describe the methods they have used to isolate, quantify and analyse microRNAs in the development of diabetic nephropathy.

  4. DIALYSIS

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. The rationale and design of the Beta-blocker to LOwer CArdiovascular Dialysis Events (BLOCADE) Feasibility Study (pages 140–147)

      Matthew A Roberts, Helen L Pilmore, Francesco L Ierino, Sunil V Badve, Alan Cass, Amit X Garg, Carmel M Hawley, Nicole M Isbel, Henry Krum, Elaine M Pascoe, Andrew M Tonkin, Liza A Vergara, Vlado Perkovic and for theBLOCADE Study Collaborative Group

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12362

      Summary at a Glance

      This study aimed to reduce cardiovascular (CV) events among dialysis patients. This is a trial design paper for the feasibility of a randomized controlled trial to evaluate beta-blockade (carvedilol 3.125 mg bid titrated to 6.25 mg bid or heart rate threshold 55 beats per minute vs placebo) among patients on dialysis. The feasibility will inform recruitment, logistics and intra-dialytic hypotension. Findings will be used to design full-scale study on CV outcomes.

    2. Initiating acute dialysis at earlier Acute Kidney Injury Network stage in critically ill patients without traditional indications does not improve outcome: A prospective cohort study (pages 148–154)

      Cynthia Ciwei Lim, Chieh Suai Tan, Manish Kaushik and Han Khim Tan

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12364

      Summary at a Glance

      This was a single-centre prospective cohort study of medical and surgical intensive care patients with acute kidney injury studying outcomes following renal replacement therapy.

      Acute renal replacement therapy was initiated in 140 patients: traditional indications in 56 (40%); Acute Kidney Injury Network (AKIN) Stage 3 without traditional indications in 38 (27%); and AKIN Stage 1 or 2 with ‘compelling’ conditions in 46 (33%) patients.

      Initiating dialysis at earlier AKIN stage did not improve survival in patients without traditional indications.

    3. Patients with diabetes as the primary kidney disease have a worse survival than patients with comorbid diabetes in chronic haemodialysis patients (pages 155–160)

      Hung-Chih Chen, Che-Yi Chou, Yi-Tzone Hsiao, Chih-Chia Liang, Huey-Liang Kuo, Chiz-Tzung Chang, Jiung-Hsiun Liu, I-Kuan Wang and Chiu-Ching Huang

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12376

      Summary at a Glance

      This prospective cohort-study addresses whether the survival of chronic haemodialysis patients with diabetes as a primary disease is different from those who have diabetes as a comorbidity.

    4. Icodextrin decreases technique failure and improves patient survival in peritoneal dialysis patients (pages 161–167)

      I-Kuan Wang, Yu-Fen Li, Jin-Hua Chen, Chih-Chia Liang, Yao-Lung Liu, Hsin-Hung Lin, Chiz-Tzung Chang, Wen-Chen Tsai, Tzung-Hai Yen and Chiu-Ching Huang

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12375

      Summary at a Glance

      This study investigated whether icodextrin use can decrease technique failure and prolong patient survival in incident PD patients. The use of icodextrin once daily can decrease technique failure and improve survival in incident PD patients. This suggests that the use of icodetrin will be of benefit for PD patients.

  5. TRANSPLANTATION

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. Early withdrawal of calcineurin inhibitor from a sirolimus-based immunosuppression stabilizes fibrosis and the transforming growth factor-β signalling pathway in kidney transplant (pages 168–176)

      Regiane F Rivelli, Renato T Gonçalves, Maurilo Leite Jr, Marcos André R Santos, Alvimar G Delgado, Lucio R Cardoso and Christina M Takiya

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12368

      Summary at a Glance

      In this prospective randomised controlled trial the withdrawal of calcineurin inhibitor therapy in moderate risk renal allograft recipients was associated with improvement in histological status of the transplant.

    2. A 25-year experience of kidney transplantation in Thailand: Report from the Thai Transplant Registry (pages 177–183)

      Kajohnsak Noppakun, Atiporn Ingsathit, Cholatip Pongskul, Nalinee Premasthian, Yingyos Avihingsanon, Adisorn Lumpaopong, Kriangsak Vareesangthip, Vasant Sumethkul and for theSubcommittee for Kidney Transplant Registry and Thai Transplantation Society

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12378

      Summary at a Glance

      This report from the Thai transplant registry summarises 25 years of data collected between 1987 and 2012. It is the largest kidney transplant registry in South-East Asia, incorporating data from 26 centres across the country with 3808 recipients included. As well as the dramatic increase in the number of kidney transplants being performed annually, the evolution of practice over this time period is also evident.

  6. CHRONIC RENAL DISEASE

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. Implementation of renal key performance indicators: Promoting improved clinical practice (pages 184–193)

      Nigel D Toussaint, Lawrence P McMahon, Gregory Dowling, Jenny Soding, Maria Safe, Richard Knight, Kathleen Fair, Leanne Linehan, Rowan G Walker and David A Power

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12366

      Summary at a Glance

      The authors implemented renal key performance indicators to improve outcomes and established limited gains in two of them, namely, the proportion of home dialysis patients dialysing and timely listing of patients for transplantation.

    2. Urinary Emmprin, matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 as potential biomarkers in children with ureteropelvic junction narrowing on conservative treatment (pages 194–200)

      Fengyan Tian, Chaohui Gu, Zhanzheng Zhao, Luping Li, Shan Lu and Zhenzhen Li

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12371

      Summary at a Glance

      This is a study designed to validate the use of urinary extracellular matrix metalloproteinase inducer (Emmprin), matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase 1 (TIMP-1) as a marker of ureteric obstruction. The authors found that these three proteins increased in the obstruction group during their follow-up. The authors concluded that urinary MMP and related proteins may be noninvasive potential biomarkers that could be used for long-term follow-up of children with UPJ narrowing on conservative treatment to determine those who might develop obstruction.

    3. Is renal hyperfiltration protective in chronic kidney disease-stage 1 pregnancies? A step forward unravelling the mystery of the effect of stage 1 chronic kidney disease on pregnancy outcomes (pages 201–208)

      Giorgina Barbara Piccoli, Rossella Attini, Federica Neve Vigotti, Silvia Parisi, Federica Fassio, Arianna Pagano, Marilisa Biolcati, Domenica Giuffrida, Alessandro Rolfo and Tullia Todros

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12372

      Summary at a Glance

      In a historical prospective study in 383 within 14-gestational week pregnancies with stage 1 CKD, Piccoli et al. showed that pregnancy outcomes was not affected by hyperfiltration. However, stage 1 CKD was associated with prematurity and low birth weight.

    4. Net endogenous acid production and mortality in NHANES III (pages 209–215)

      Hunter K Huston, Matthew K Abramowitz, Yingying Zhang, Tom Greene and Kalani L Raphael

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12365

      Summary at a Glance

      Net endogenous acid production (NEAP), an estimate of net dietary acid intake, is a risk factor for glomerular filtration rate (GFR) decline and might contribute to excess mortality risk in chronic kidney disease. Huston et al. calculated NEAP among 16 906 adult participants in the NHANES III and interestingly found that higher NEAP is not associated with higher mortality in people with low or normal GFR. The underlying mechanism of this observation is still unestablished.

  7. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. Ethnic disparity in prevalence of diabetic kidney disease in an Asian primary healthcare cluster (pages 216–223)

      Ping Tyug Loh, Matthias Paul Han Sim Toh, Joseph Antonio Molina and Anantharaman Vathsala

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12379

      Summary at a Glance

      This study aimed to evaluate the prevalence of diabetic kidney disease in a primary care cluster in Singapore and identify its risk factors in a multi-ethnic Asian population. This would be the first out of Asia to describe the epidemiology of diabetic kidney disease in a multi-ethnic population.

  8. CORRESPONDENCES

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLES
    5. DIALYSIS
    6. TRANSPLANTATION
    7. CHRONIC RENAL DISEASE
    8. NEPHROLOGY IN HIGH RISK POPULATIONS/INDIGENOUS
    9. CORRESPONDENCES
    1. Autoimmune pancreatitis and minimal change nephrotic syndrome: an unusual association? (pages 225–226)

      Yuka Okuyama, Haruhito Adam Uchida, Masafumi Tenta, Tomokazu Nunoue, Ryoko Umebayashi, Hiroshi Morinaga, Shinji Kitamura, Yohei Maeshima, Hitoshi Sugiyama and Jun Wada

      Article first published online: 24 FEB 2015 | DOI: 10.1111/nep.12370

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