Nephrology

Cover image for Vol. 20 Issue 4

April 2015

Volume 20, Issue 4

Pages i–ii, 227–308

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. Issue Information (pages i–ii)

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12443

  2. EDITORIAL

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
  3. REVIEW ARTICLE

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. You have free access to this content
      Aortic dissection in patients with autosomal dominant polycystic kidney disease: A series of two cases and a review of the Literature (pages 229–235)

      Angelo Silverio, Costantina Prota, Marco Di Maio, Maria Vincenza Polito, Francesco Maria Cogliani, Rodolfo Citro, Alberto Gigantino, Severino Iesu and Federico Piscione

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12373

      Summary at a Glance

      Aortic dissection is rarely associated with ADPKD. In this study, the authors have performed a systematic review of the clinical characteristics of aortic dissection, and suggest that it should be considered in the differential diagnosis of acute chest pain in patients with ADPKD.

  4. DIALYSIS

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. Semaphorin 3A serum levels are influenced by haemodialysis: What clinical significance? (pages 236–242)

      Valeria Cernaro, Silvia Lucisano, Antoine Buemi, Luca Visconti, Viviana Lacava, Antonio Lacquaniti, Domenico Santoro, Saverio Loddo and Michele Buemi

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12393

      Summary at a Glance

      The semaphorins are a family of guidance molecules, and Sema3A, a secreted semaphorin, is important not only in axonal development, but also in the neural control of bone metabolism. This study for the first time identifies differences in Sema3A between patients with CKD and normal subjects and identifies changes during dialysis that may have implications for the development of CKD mineral and bone disorders.

    2. Trends of cost and mortality of patients on haemodialysis with end stage renal disease (pages 243–249)

      Yu-Kang Chang, Chih-Cheng Hsu, Pei-Chun Chen, Yi-Shan Chen, Shang-Jyh Hwang, Tsai-Chung Li, Chiu-Ching Huang, Chung-Yi Li and Fung-Chang Sung

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12380

      Summary at a Glance

      This paper from Taiwan explores associations between fixed capitation payment introduced in a resource constrained health service and actual costs for health services. It shows improving trends in mortality across dialysis cohorts but a trend to increasing use of emergency services and other costs that may offset the fixed payment. Further studies are required to assess what factors contribute to these changes in costs and survival.

    3. Feasibility study of colestipol as an oral phosphate binder in hemodialysis patients (pages 250–256)

      Christopher J Hood, Martin J Wolley, Angela L Kam, Jamie C Kendrik-Jones and Mark R Marshall

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12388

      Summary at a Glance

      Phosphate binders are the predominant treatment at present for hyperphosphataemia in dialysis, and more research is needed to evaluate newer agents with phosphate-lowering efficacy but with less adverse effects than currently prescribed binders. This study outlines a prospective trial to assess the effects of colestipol, a bile acid sequestrant, on phosphate-binding capacity and biochemical parameters in haemodialysis patients.

    4. Design and participant baseline characteristics of ‘A Clinical Trial of IntensiVE Dialysis’: The ACTIVE Dialysis Study (pages 257–265)

      Meg J Jardine, LI Zuo, Nicholas A Gray, Janak de Zoysa, Christopher T Chan, Martin P Gallagher, Kirsten Howard, Stephane Hertier, Alan Cass, Vlado Perkovic and on behalf of the ACTIVE Dialysis Steering Committee

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12385

      Summary at a Glance

      This paper forms the background for the soon to be released ACTIVE Dialysis Study – an important study comparing quality of life in patients randomly assigned to conventional or extended hours haemodialysis.

  5. PROGRESSIVE CHRONIC RENAL DISEASE

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. Erythropoietin pretreatment ameliorates renal ischaemia-reperfusion injury by activating PI3K/Akt signalling (pages 266–272)

      Jiong Zhang, Yu-rong Zou, Xiang Zhong, Hanlu Ding Fei Deng, Lei Pu, Kun Peng and Li Wang

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12384

      Summary at a Glance

      In this study the authors showed that erythropoietin pretreatment attenuated renal ishcaemia/re-perfusion injury by suppressing inflammation, mainly be activating PI3K/Akt signalling though EPOR activation.

    2. Association of a polymorphism of the interleukin 6 receptor gene with chronic kidney disease in Japanese individuals (pages 273–278)

      Hideki Horibe, Tetsuo Fujimaki, Mitsutoshi Oguri, Kimihiko Kato, Reiko Matsuoka, Shintaro Abe, Fumitaka Tokoro, Masazumi Arai, Toshiyuki Noda, Sachiro Watanabe and Yoshiji Yamada

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12381

      Summary at a Glance

      The authors detected a novel SNP in the IL6R gene that correlates with CKD in a reasonably large Japanese cohort.

  6. GENERAL NEPHROLOGY

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. Comparison of intrarenal renin-angiotensin system activity in diabetic versus non-diabetic patients with overt proteinuria (pages 279–285)

      Ji Hyeon Park, Hye Ryoun Jang, Jong-Ho Lee, Jung Eun Lee, Wooseong Huh, Kyu-Beck Lee, Young-Joo Kwon, Jun Young Do, Hye Young Kim and Yoon-Goo Kim

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12383

      Summary at a Glance

      Clinical study on 116 subjects with proteinuria documenting increased urinary excretion of renin and angiotensinogen among patients with diabetes compared to non-diabetics. Plasma renin and angiotensinogen levels did not differ between the two groups suggesting the enhanced role of intra-renal RAS activity among patients with diabetes and proteinuria.

  7. CLINICAL GLOMERULONEPHRITIS

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. Membranoproliferative glomerulonephritis and C3 glomerulonephritis: Frequency, clinical features, and outcome in children (pages 286–292)

      Yusuke Okuda, Kenji Ishikura, Riku Hamada, Ryoko Harada, Tomoyuki Sakai, Yuko Hamasaki, Hiroshi Hataya, Ryuji Fukuzawa, Kentaro Ogata and Masataka Honda

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12382

      Summary at a Glance

      The emergence of the term C3 glomerulonephropathy (C3 glomerulonephritis) in recent years is a step on the pathway towards an aetiological classification of glomerular disease, reflecting our increased understanding of disease pathogenesis. Okuda et al. present a retrospective study from two paediatric centres in Japan on the clinical features of C3 glomerulopathy in children re-classified as having this condition.

    2. Basal glucosuria is ubiquitous in critically ill patients (pages 293–296)

      Richard Brunner, Annabella Kurz, Gabriel Adelsmayr and Ulrike Holzinger

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12377

    3. Dangers of broth after transplantation (pages 297–299)

      Shikha Aggarwal, Louisa Sukkar, Lucy Wynter, Kate Richards, Jason Cheung and Steve J Chadban

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12391

  8. COCHCRANE COMMENTARIES

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
  9. CORRESPONDENCE

    1. Top of page
    2. Issue Information
    3. EDITORIAL
    4. REVIEW ARTICLE
    5. DIALYSIS
    6. PROGRESSIVE CHRONIC RENAL DISEASE
    7. GENERAL NEPHROLOGY
    8. CLINICAL GLOMERULONEPHRITIS
    9. COCHCRANE COMMENTARIES
    10. CORRESPONDENCE
    1. Anuric renal failure in a patient with Waldenstrom's macroglobulinaemia (page 306)

      Jonathan Ling, David Challis, William Johnson and Steven Yew

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12389

    2. Ultra-low dose heparin locks perform well on non-tunnelled temporary haemodialysis catheters (pages 307–308)

      Hui Liang, Xu-sheng Liu, Yu-chi Wu, La Zhang, Qi-zhan Lin, Xi-na Jie, Min Yang, Jing-xu Su and Yong-sheng Wang

      Article first published online: 25 MAR 2015 | DOI: 10.1111/nep.12387

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