Nephrology

Cover image for Vol. 20 Issue 9

September 2015

Volume 20, Issue 9

Pages i–ii, 585–669

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
    1. You have free access to this content
      Issue Information (pages i–ii)

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12581

  2. PROGRESSIVE CHRONIC RENAL DISEASE

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
    1. Relationship between vascular function indexes, renal arteriolosclerosis, and renal clinical outcomes in chronic kidney disease (pages 585–590)

      Tamehachi Namikoshi, Sohachi Fujimoto, Daisuke Yorimitsu, Chieko Ihoriya, Yasuo Fujimoto, Norio Komai, Tamaki Sasaki and Naoki Kashihara

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12483

      Summary at a Glance

      Cross sectional study on 55 patients with biopsy-proven CKD showing cardio–ankle vascular index associated with clinical outcomes (eGFR, ACR). Needs evaluation in prospective study with ESRD.

    2. Micro-vesicles derived from bone marrow stem cells protect the kidney both in vivo and in vitro by microRNA-dependent repairing (pages 591–600)

      Juan He, Yan Wang, Xingyan Lu, Bei Zhu, Xiaohua Pei, Jianqing Wu and Weihong Zhao

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12490

      Summary at a Glance

      This paper has had three reviews with mixed recommendations. The topic is novel – use of mesenchymal stem cells to deliver miRNA via endosome vesicles. The English may require some editorial proofing, but otherwise suitable for publication.

    3. Anaemia management and mortality risk in newly visiting patients with chronic kidney disease in Japan: The CKD-ROUTE study (pages 601–608)

      Soichiro Iimori, Shotaro Naito, Yumi Noda, Hidenori Nishida, Hiromi Kihira, Naofumi Yui, Tomokazu Okado, Sei Sasaki, Shinichi Uchida and Tatemitsu Rai

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12493

      Summary at a Glance

      This interesting paper demonstrates the association between anaemia, iron deficiency and increased mortality (both cardiovascular and all-cause mortality) in a cohort of Japanese people with CKD. While the prescription of ESAs increased significantly in a 6-month period, the iron replacement seemed to be less so, suggesting a potential opportunity for future clinical intervention.

  3. DIALYSIS

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
    1. Mast cell involvement in the progression of peritoneal fibrosis in rats with chronic renal failure (pages 609–616)

      Itsuro Kazama, Asuka Baba, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara and Masahiro Tachi

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12489

      Summary at a Glance

      Using a rat model of CKD and peritoneal fibrosis, the authors demonstrated the possible involvement of mast cells in the pathogenesis of peritoneal fibrosis, as indicated by their increased numbers and activity.

    2. Hyperleptinaemia, insulin resistance and survival in peritoneal dialysis patients (pages 617–624)

      Liou Cao, Shan Mou, Wei Fang, Leyi Gu, Jiaying Huang, Aiping Gu, Jiaqi Qian and Zhaohui Ni

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12491

      Summary at A Glance

      This study of 157 peritoneal dialysis patients assessed the potential relationship of insulin resistance, and its related factors such as leptin, to glucose and lipid metabolism. They demonstrated that insulin resistance correlated with age, leptin and triglyceride levels, and was negatively correlated with BMI. In addition they showed that dialysis duration, leptin levels, nPCR and hsCRP may be important risk factors for mortality in PD patients.

    3. Suboptimal vitamin K status and its risk factors in a population of Chinese chronic haemodialysis patients (pages 625–631)

      Yunlin Feng, Yizhe Ruan, Qiang He, Wensong Zhang and Li Wang

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12494

      Summary at a Glance

      Vitamin K deficiency is common in dialysis patients. Defining vitamin K deficiency by %ucOC, suboptimal vitamin K levels appear common in Chinese patients. Time on dialysis and LDL cholesterol level predict vitamin K deficiency.

    4. Evaluation of uraemic pruritus in long-term dialysis patients using a modified Chinese scale (pages 632–638)

      Wei-Yun Wang, Der-Cherng Tarng, Li-Chi Chiang, Chi-Ming Chu and Kwua-Yun Wang

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12495

      Summary at a Glance

      The authors of this manuscript try to examine the reliability and validity of a modified Chinese version of the uremic pruritus scale and identify the predictors for the severity of uremic pruritus among long-term dialysis patients. After optimisation for reliability, the scale retained 7 items. The results showed that the scale had predictive and discriminative validity. High intact-parathyroid hormone and creatinine clearance rate were important predictors for the severity of uremic pruritus. The modified Chinese scale is a useful tool for clinically assessing the various degrees of itching among long-term dialysis patients.

    5. Factors associated with serum soluble inhibitors of Wnt-β-catenin signaling (sclerostin and dickkopf-1) in patients undergoing peritoneal dialysis (pages 639–645)

      Shunsuke Yamada, Kazuhiko Tsuruya, Masanori Tokumoto, Hisako Yoshida, Hiroaki Ooboshi and Takanari Kitazono

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12509

      Summary at a Glance

      This cross-sectional study investigates the metabolism and association between serum sclerostin and Dkk-1 levels and serum mineral markers in 74 outpatients under PD treatment. Multivariable linear regression analyses show that both serum sclerostin and Dkk-1 level were significantly associated with the serum biomarkers of CKD-MBD, indicating the involvement of soluble Wnt-β-catenin inhibitors in the pathogenesis of CKD-MBD.

  4. ACUTE KIDNEY INJURY

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
    1. Neutrophil gelatinase-associated lipocalin attenuates injury in the rat cecal ligation and puncture model of sepsis via apoptosis inhibition (pages 646–653)

      Shuangping Zhao, Yangjing Wei and Daomiao Xu

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12498

      Summary at a Glance

      Injections of NGAL (neutrophil gelatinase-associated lipocalin) were found to attenuate kidney injury in a rat sepsis model most likely by reducing cell death.

  5. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
    1. Extracapillary proliferation is an independent predictive factor in Immunoglobulin A nephropathy (pages 654–659)

      Ilaria Serriello, Rosaria Polci, Sandro Feriozzi, Antonietta Gigante, Salvatore Di Giulio, Margherita Rosa, Marco Galliani, Massimo Morosetti, Francesco Pugliese, Tommasangelo Petitti, Andrea Onetti Muda and Konstantinos Giannakakis

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12497

      Summary at a Glance

      In this manuscript, the authors evaluated the predictive value of the Oxford classification of IgA nephropathy in a multi-centre, single region group of patients from central Italy and showed that extracapillary proliferation was an independent predictive factor of IgA nephropathy.

  6. COCHRANE COMMENTARIES

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
  7. CORRESPONDENCES

    1. Top of page
    2. Issue Information
    3. PROGRESSIVE CHRONIC RENAL DISEASE
    4. DIALYSIS
    5. ACUTE KIDNEY INJURY
    6. DIABETIC NEPHROPATHY (CLINICAL AND EXPERIMENTAL)
    7. COCHRANE COMMENTARIES
    8. CORRESPONDENCES
    1. Rituximab can induce remission of nephrotic syndrome in the absence of peripheral B-cells (pages 667–668)

      Ilse M Rood, Job Huussen, Jack F Wetzels and Jeroen K Deegens

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12492

    2. Membranous nephropathy and central retinal vein occlusion (pages 668–669)

      Nageswara Reddy Padimi, Sangeetha Lakshmi Boju, Harikishore Reddy Mogili, Swathi Kalle, Ram Rapur and Siva Kumar Vishnubhotla

      Article first published online: 16 AUG 2015 | DOI: 10.1111/nep.12499

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