Nephrology

Cover image for Vol. 21 Issue 3

March 2016

Volume 21, Issue 3

Pages 165–267

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Review Articles
    4. Original Articles
    5. Brief Communications
    6. Correspondences
    7. Correspondences (Instructive Case)
    1. You have free access to this content
      Issue Information (pages 165–168)

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12598

  2. Review Articles

    1. Top of page
    2. Issue Information
    3. Review Articles
    4. Original Articles
    5. Brief Communications
    6. Correspondences
    7. Correspondences (Instructive Case)
    1. PROGRESSIVE CHRONIC RENAL DISEASE

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      Indoxyl sulphate and kidney disease: Causes, consequences and interventions (pages 170–177)

      Robert J Ellis, David M Small, David A Vesey, David W Johnson, Ross Francis, Luis Vitetta, Glenda C Gobe and Christudas Morais

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12580

      Summary at a Glance

      Indoxyl sulphate is one of many potential protein bound uremic toxins. This review explores the mechanisms behind elevated indoxyl sulphate levels in renal impairment; the effects this may have on the organism; and methods that may lower these elevated levels.

    2. DIALYSIS

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      Economic evaluations of interventions to manage hyperphosphataemia in adult haemodialysis patients: A systematic review (pages 178–187)

      Rana Rizk, Mickaël Hiligsmann, Mirey Karavetian and Silvia MAA Evers

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12584

      Summary at a Glance

      This is an interesting systematic review of studies specifically addressing the economic evaluation of interventions to lower phosphate in dialysis patients. Only 12 studies provided information, all relating to phosphate binders. In general, the overall quality of these studies was suboptimal; therefore, firm conclusions were difficult to be drawn about which binders were best, although calcium-based binders seemed most cost-effective as first-line therapy.

    3. TRANSPLANTATION

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      Intraoperative biomarkers in renal transplantation (pages 188–199)

      Laura-Nanna Lohkamp, Robert Öllinger, Antonios Chatzigeorgiou, Ben Min-Woo Illigens and Timo Siepmann

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12556

      Summary at a Glance

      This review summarizes the current evidence and potential clinical utility of established and novel renal biomarkers in predicting kidney transplant outcomes, including delayed graft function, acute rejection and graft loss.

  3. Original Articles

    1. Top of page
    2. Issue Information
    3. Review Articles
    4. Original Articles
    5. Brief Communications
    6. Correspondences
    7. Correspondences (Instructive Case)
    1. PROGRESSIVE CHRONIC RENAL DISEASE

      Maternal protein restriction reduces perlecan at mid-metanephrogenesis in rats (pages 200–208)

      Xiao-Shan Tang, Qian Shen, Jing Chen, Xi-Liang Zha and Hong Xu

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12583

      Summary at a Glance

      This paper shows the expression pattern of perlecan during kidney development in maternal protein restriction rat. Decreased expression of perlecan was found in mid-metanephrogenesis accompany with altered cell fate. It suggests the important role of perlecan in perinatal kidney programming.

    2. High mutation rate of NPHP3 in 18 Chinese infantile nephronophthisis patients (pages 209–216)

      Liangzhong Sun, Huajuan Tong, Haiyan Wang, Zhihui Yue, Ting Liu, Hongrong Lin, Jun Li and Changxi Wang

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12563

      Summary at a Glance

      The manuscript examined the mutations of NPHP2 and NPHP3 and clinical features in 18 Chinese infantile NPHP patients. Since NPHP is one of frequent causes in children with end-stage renal disease, the findings observed in this study may provide some meaningful information in the field of paediatric nephrology.

    3. DIALYSIS

      Baseline characteristics of the omega-3 fatty acids (Fish oils) and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) study (pages 217–228)

      Andrea K Viecelli, Elaine M Pascoe, Kevan R Polkinghorne, Carmel M Hawley, Peta-Anne Paul-Brent, Sunil V Badve, Alan Cass, David W Johnson, Peter G Kerr, Trevor A Mori, Anish Scaria, Seong L Hooi, Meng L Ong, Ashley B Irish and on behalf of the FAVOURED Study Team

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12573

      Summary at a Glance

      The Fish oils and Aspirin in Vascular access OUtcomes in REnal Disease (FAVOURED) trial investigated whether 3 months of omega-3 polyunsaturated fatty acids, either alone or in combination with aspirin, would effectively reduce primary access failure of de novo arteriovenous fistulae. This report presents the baseline characteristics of all study participants, and examines whether study protocol amendments successfully increased recruitment of a broader and more representative haemodialysis cohort, including patients already receiving aspirin, and compares Malaysian participants with those from Australia, New Zealand and the United Kingdom. The FAVOURED study participants were on average younger and had less ischaemic heart disease than in contemporary national registry reports, and these differences were reduced as a consequence of including patients already receiving aspirin.

    4. Effect of colestilan on serum phosphorus in dialysis patients: A meta-analysis of the literature (pages 229–235)

      Qian Zhang, Ming Li and Jing Chen

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12588

      Summary at a Glance

      Colestilan, a non-absorbable non-metallic anion exchange resin, is used traditionally as a lipid-lowering drug; however, recent interest has been with its potential use as a phosphate binder. This systematic review evaluates the limited but important literature relating to trials assessing the benefits and adverse effects of colestilan for lowering phosphate levels in patients on dialysis.

    5. Glycaemic control is a predictor of infection-related hospitalization on haemodialysis patients: Miyazaki Dialysis Cohort study (MID study) (pages 236–240)

      Tatsunori Toida, Yuji Sato, Hideto Nakagawa, Hiroyuki Komatsu, Masao Kikuchi, Shigehiro Uezono, Kazuhiro Yamada, Tabito Ishihara, Shuichi Hisanaga, Kazuo Kitamura and Shouichi Fujimoto

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12587

      Summary at a Glance

      A prospective cohort study of haemodialysis patients with diabetes, identifying an increased risk of infection-related hospitalizations in those with poor glycaemic control. Emphasises the importance of glucose management in dialysis population.

    6. Survival outcomes of supportive care versus dialysis therapies for elderly patients with end-stage kidney disease: A systematic review and meta-analysis (pages 241–253)

      Celine Foote, Sradha Kotwal, Martin Gallagher, Alan Cass, Mark Brown and Meg Jardine

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12586

      Summary at a Glance

      Multiple factors may influence the decision-making of initiating dialysis in elderly patients with end-stage renal disease (ESRD). This systematic review of cohort studies or randomized controlled trials found that 1-year survival of elderly patients who were dialyzed had similar 1-year survival with those treated conservatively for their ESRD. However, available data on conservative care are limited and there is probably a substantial publication bias.

    7. TRANSPLANTATION

      Different faces of Nocardia infection in renal transplant recipients (pages 254–260)

      Shailendra Shrestha, John Kanellis, Tony Korman, Kevan R Polkinghorne, Fiona Brown, Ming Yii, Peter G Kerr and William Mulley

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12585

      Summary at a Glance

      This manuscript examines the spectrum of Nocardia infections in a renal transplant centre in Australia. The findings observed in this study provide useful information in the fields of renal transplantation.

  4. Brief Communications

    1. Top of page
    2. Issue Information
    3. Review Articles
    4. Original Articles
    5. Brief Communications
    6. Correspondences
    7. Correspondences (Instructive Case)
    1. PROGRESSIVE CHRONIC RENAL DISEASE

      Irreversible severe kidney injury and anuria in a 3-month-old girl with atypical haemolytic uraemic syndrome under administration of eculizumab (pages 261–265)

      Yusuke Okuda, Kenji Ishikura, Chikako Terano, Ryoko Harada, Riku Hamada, Hiroshi Hataya, Kentaro Ogata and Masataka Honda

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12582

  5. Correspondences

    1. Top of page
    2. Issue Information
    3. Review Articles
    4. Original Articles
    5. Brief Communications
    6. Correspondences
    7. Correspondences (Instructive Case)
    1. CORRESPONDENCE (INSTRUCTIVE CASE)

      Kidney Allograft Abscess: An Unusual Cause of Peritonitis in a Patient on Peritoneal Dialysis (page 266)

      Desmond YH Yap, Maggie MY Mok, Gary CW Chan, Bo Ying Choy and Tak Mao Chan

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12568

  6. Correspondences (Instructive Case)

    1. Top of page
    2. Issue Information
    3. Review Articles
    4. Original Articles
    5. Brief Communications
    6. Correspondences
    7. Correspondences (Instructive Case)
    1. Tumoural calcinosis in a young woman (page 267)

      Gregor Young, Tracey Putt, John Schollum and Robert Walker

      Article first published online: 28 JAN 2016 | DOI: 10.1111/nep.12571

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