• 1
    Tack J, Talley NJ, Camilleri M et al. Functional gastroduodenal disorders. Gastroenterology 2006; 130: 146679.
  • 2
    Jorgensen LS, Bonlokke L, Christensen NJ. Life strain, life events, and autonomic response to a psychological stressor in patients with chronic upper abdominal pain. Scand J Gastroenterol 1986; 21: 60513.
  • 3
    Locke GR, Weaver AL, Melton LJ et al. Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case–control study. Am J Gastroenterol 2004; 99: 3507.
    Direct Link:
  • 4
    Chen TS, Lee YC, Chang FY et al. Psychosocial distress is associated with abnormal gastric myoelectrical activity in patients with functional dyspepsia. Scand J Gastroenterol 2006; 41: 7916.
  • 5
    Hefeiz HB, Al-Quorain A, Al-Mangoor S et al. Life events stress in functional dyspepsia: a case–control study. Eur J Gastroenterol Hepatol 1997; 9: 216.
  • 6
    Budavari AI, Olden KW. Psychosocial aspects of functional gastrointestinal disorders. Gastroenterol Clin North Am 2003; 32: 477506.
  • 7
    Wilhelmsen I, Haug TT, Ursin H et al. Discriminant analysis of factors distinguishing patients with functional dyspepsia from patients with duodenal ulcer. Significance of somatization. Dig Dis Sci 1995; 40: 110511.
  • 8
    Fischler B, Tack J, De Gucht V et al. Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia. Gastroenterology 2003; 124: 90310.
  • 9
    Van Oudenhove L, Demyttenaere K, Tack J et al. Central nervous system involvement in functional gastrointestinal disorders. Best Pract Res Clin Gastroenterol 2004; 18: 66380.
  • 10
    Geeraerts B, Vanderberghe J, Van Oudenhove L et al. Influence of experimentally induced anxiety on gastric sensorimotor function in humans. Gastroenterology 2005; 129: 143744.
  • 11
    Van Oudenhove L, Vandenberghe J, Vos R et al. Abuse history, depression, and somatization are associated with gastric sensitivity and gastric emptying in functional dyspepsia. Psychosom Med 2011; 73: 64855.
  • 12
    Taché Y, Martinez V, Million M et al. Stress and the gastrointestinal tract: III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol 2001; 280: G1737.
  • 13
    Stam R, Croiset G, Akkermans LM et al. Effects of novelty and conditioned fear on small intestinal and colonic and behavior in the rat. Physiol Behav 1995; 58: 8039.
  • 14
    Rao SS, Hatfield RA, Suls JM et al. Psychological and physical stress induce differential effects on human colonic motility. Am J Gastroenterol 1998; 93: 98590.
    Direct Link:
  • 15
    Mönnikes H, Tebbe JJ, Hildebrandt M et al. Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity. Dig Dis 2001; 19: 20111.
  • 16
    Bale TL, Vale WW. CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 2004; 44: 52557.
  • 17
    Caso JR, Leza JC, Menchen L. The effects of physical and psychological stress on the gastrointestinal tract: lessons from animal models. Curr Mol Med 2008; 8: 299312.
  • 18
    Stengel A, Tachè Y. Neuroendocrine control of the gut during stress: corticotrophin-releasing factor signalling pathways in the spotlight. Annu Rev Physiol 2009; 71: 21939.
  • 19
    Hveem K, Hausken T, Svebak S et al. Gastric antral motility in functional dyspepsia. Effect of mental stress and cisapride. Scand J Gastroenterol 1996; 31: 4527.
  • 20
    Hausken T, Svebak S, Wilhelmsen I et al. Low vagal tone and antral dysmotility in patients with functional dyspepsia. Psychosom Med 1993; 55: 1222.
  • 21
    Haug TT, Svebak S, Hausken T et al. Low vagal activity as mediating mechanism for the relationship between personality factors and gastric symptoms in functional dyspepsia. Psychosom Med 1994; 56: 1816.
  • 22
    Kroenke K, Spitzer RL. The PHQ-9: a new depression and diagnostic severity measure. Psychiatr Ann 2002; 32: 50921.
  • 23
    Spitzer RL, Kroenke K, Williams JB. et al. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med 2006; 166: 10927.
  • 24
    Bremner JD, Bolus R, Mayer EA. Psychometric properties of the Early Trauma Inventory-Self Report. J Nerv Ment Dis 2007; 195: 2118.
  • 25
    Ott V, Friedrich M, Prilop S et al. Food anticipation and subsequent food withdrawal increase serum cortisol in healthy men. Physiol Behav 2011; 103: 5949.
  • 26
    Yoshida K, Utsunomiya T, Morooka T et al. Mental stress test is an effective inducer of vasospastic angina pectoris: comparison with cold pressor, hyperventilation and master two-step exercise test. Int J Cardiol 1999; 70: 15563.
  • 27
    Kamath MW, Fallen EL. Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng 1993; 21: 245311.
  • 28
    Bootsma MC, Swenne C, vanBolhuis H et al. Heart rate and heart rate variability as indexes of sympathovagal balance. Am J Physiol 1994; 266: 156571.
  • 29
    Goldberger JJ. Sympathovagal balance: how should we measure it? Am J Physiol 1999; 276: 127380.
  • 30
    Kudielka BM, Buske-Kirschbaum A, Hellhammer DH et al. HPA axis responses to laboratory psychosocial stress in healthy elderly adults, younger adults and children: impact of age and gender. Psychoneuroendocrinology 2004; 29: 8398.
  • 31
    Tougas G, Spaziani R, Hollerbach S et al. Cardiac autonomic function and oesophageal acid sensitivity in patients with non-cardiac chest pain. Gut 2001; 49: 70612.
  • 32
    Cuomo R, De Giorgi F, Adinolfi L et al. Oesophageal acid exposure and altered neurocardiac function in patients with GERD and idiopathic cardiac dysrhythmias. Aliment Pharmacol Ther 2006; 2: 36170.
  • 33
    Castillo EJ, Camilleri M, Locke GR et al. A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia. Clin Gastroenterol Hepatol 2004; 2: 98596.
  • 34
    Van Oudenhove L, Vandenberghe J, Geeraerts B et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation? Gut 2008; 57: 166673.
  • 35
    Larauche M, Mulak A, Tachè Y. Stress-related alterations of visceral sensation: animal models for irritable bowel syndrome study. Neurogastroenterol Motil 2011; 17: 21334.
  • 36
    Hsu YC, Liou JM, Liao SC et al. Psychopathology and personality trait in subgroups of functional dyspepsia based on Rome III criteria. Am J Gastroenterol 2009; 104: 253442.
  • 37
    Aro P, Talley NJ, Ronkainen J et al. Anxiety is associated with uninvestigated and functional dyspepsia (Rome III criteria) in a Swedish population-based study. Gastroenterology 2009; 137: 94100.
  • 38
    Lorena SL, Figueiredo MJ, Almeida JR et al. Autonomic function in patients with functional dyspepsia assessed by 24-hour heart rate variability. Dig Dis Sci 2002; 47: 2731.
  • 39
    Park DI, Rhee PL, Kim YH et al. Role of autonomic dysfunction in patients with functional dyspepsia. Dig Liver Dis 2001; 33: 46471.
  • 40
    Yin J, Levanon D, Chen JD. Inhibitory effects of stress on postprandial gastric myoelectrical activity and vagal tone in healthy subjects. Neurogastroenterol Motil 2004; 16: 73744.
  • 41
    Kawachi I, Sparrow D, Vokonas PS et al. Decreased heart rate variability in men with phobic anxiety (data from the Normative Aging Study). Am J Cardiol 1995; 75: 8825.
  • 42
    Piccirillo G, Elvira S, Bucca C et al. Abnormal passive head-up tilt test in subjects with symptoms of anxiety power spectral analysis study of heart rate and blood pressure. Int J Cardiol 1997; 60: 12131.
  • 43
    Heitkemper M, Jarrett M, Cain K et al. Increased urine catecholamines and cortisol in women with irritable bowel syndrome. Am J Gastroenterol 1996; 91: 90613.
  • 44
    Dinan TG, Quigley EM, Ahmed SM et al. Hypothalamic-pituitary-gut axis dysregulation in irritable bowel syndrome: plasma cytokines as a potential biomarker? Gastroenterology 2006; 130: 30411.
  • 45
    Chang L, Sundaresh S, Elliott J et al. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome. Neurogastroenterol Motil 2009; 21: 14959.
  • 46
    Patacchioli FR, Angelucci L, Dellerba G et al. Actual stress, psychopathology and salivary cortisol levels in the irritable bowel syndrome (IBS). J Endocrinol Invest 2001; 24: 1737.
  • 47
    Posserud I, Agerforz P, Ekman R et al. Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress. Gut 2004; 53: 11028.
  • 48
    Böhmelt AH, Nater UM, Franke S et al. Basal and stimulated hypothalamic-pituitary. Adrenal axis activity in patients with functional gastrointestinal disorders and healthy controls. Psychosom Med 2005; 67: 28894.
  • 49
    Carlson DE, Chiu WC, Fiedler SM et al. Central neural distribution of immunoreactive Fos and CRH in relation to plasma ACTH and corticosterone during sepsis in the rat. Exp Neurol 2007; 205: 485500.
  • 50
    Watts AG. Glucocorticoid regulation of peptide genes in neuroendocrine CRH neurons: a complexity beyond negative feedback. Front Neuroendocrinol 2005; 4: 10930.
  • 51
    van den Elzen BD, van den Wijngaard RM, Tytgat GN et al. Influence of corticotropin-releasing hormone on gastric sensitivity and motor function in healthy volunteers. Eur J Gastroenterol Hepatol 2007; 19: 4017.