Cortical visual areas process intestinal information during slow-wave sleep
Article first published online: 6 DEC 2012
© 2012 Blackwell Publishing Ltd
Neurogastroenterology & Motility
Volume 25, Issue 3, pages 268–e169, March 2013
How to Cite
Pigarev, I. N., Bagaev, V. A., Levichkina, E. V., Fedorov, G. O. and Busigina, I. I. (2013), Cortical visual areas process intestinal information during slow-wave sleep. Neurogastroenterology & Motility, 25: 268–e169. doi: 10.1111/nmo.12052
- Issue published online: 17 FEB 2013
- Article first published online: 6 DEC 2012
- Received: 26 June 2012 Accepted for publication: 30 October 2012
- myoelectric activity;
- neuronal activity;
- slow-wave sleep;
- visual cortex
Background Previously we have shown that, during sleep, electrical and magnetic stimulation of areas of the stomach and small intestine evoked neuronal and EEG responses in various cortical areas. In this study we wanted to correlate natural myoelectrical activity of the duodenum with cortical neuronal activity, and to investigate whether there is a causal link between them during periods of slow-wave sleep.
Methods We have recorded the myoelectrical activity from the wall of the duodenum and activity of single neurons from three cortical visual areas in naturally sleeping cats and investigated causal interrelationship between these structures during slow-wave sleep.
Key Results About 30% of the cortical neurons studied changed their firing rate dependent on the phases of the peristaltic cycle and demonstrated selectivity to particular pattern of duodenal myoelectrical activity during slow-wave sleep. This interrelationship was never seen when awake.
Conclusions & Inferences This observation supports the hypothesis that, during sleep, the cerebral cortex switches from processing of exteroceptive and proprioceptive information to processing of interoceptive information.