Ghrelin is involved in the paracrine communication between neurons and glial cells (pages e599–e608)
B. Avau, B. De Smet, T. Thijs, A. Geuzens, J. Tack, P. Vanden Berghe and I. Depoortere
Version of Record online: 19 JUN 2013 | DOI: 10.1111/nmo.12171
Fluo-4 AM Ca2+ imaging and immunofluorescence stainings were used to study the effects of ghrelin on the interaction between neurons and glial cells in cultures of the rat nodose ganglia. Ghrelin induced only Ca2+ responses in glial cells, while neurons stained more intensively for the ghrelin receptor. Pharmacological studies revealed that NO, released by the neurons, is the neurotransmitter responsible for activation of the glial cells.