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Since its publication, it has been brought to our attention that the statistical analysis in Figs 7 and 8 is not clearly stated, which causes misunderstanding for readers. However, the overall conclusions and statements within the article are unaffected. For clarity, the detailed description of the statistical analysis methods and the revised Figs 7 (corrected) and 8 (corrected) are published below.
We apologize to our readers for the negligence.
Statistical analysis methods
The statistical analysis underlying the presentations in Figs 7 and 8 was performed as follows. First, we analyzed the difference among the same genotype at different time points. We set the control of each genotype as ‘a’. At the different time points, if there was no significant difference (P >0.05) compared with the control, the data was labeled by ‘a’; if there was significant difference compared with the control, the data was labeled by ‘b’ (P <0.05) or ‘c’ (P <0.01). Second, we analyzed the difference among different genotypes within each time point. At each time point, the WT data was set as ‘a’, and if there was no significant difference (P >0.05) between other genotypes and WT, the data of other genotypes was labeled by ‘a’; if there was significant difference between other genotypes and WT, the data of other genotypes was labeled by ‘b’ (P <0.05) or ‘c’ (P <0.01). Notably: if the two analyses obtained the same letter (‘aa’ or ‘bb’), we only labeled as one letter (‘a’ or ‘b’). And the letters of each mean were presented in alphabetical order (Figs 7 and 8), but we now present them in test order to avoid confusion (Figs 7(corrected) and 8(corrected)). In all, using this method, each figure presents the results of two analyses: of differences over time from the control time for each genotype; and of differences from the reference (WT) genotype within each time point.