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Fig. S1 Extracted compound chromatogram (ECC) of representative wheat extract analysed in positive mode electrospray ionization (ESI) using LC-MS.

Fig. S2 Relative abundance of serotonin in detached leaves with exogenously applied serotonin is comparable to the concentrations present in infected tissue.

Fig. S3 Detached leaf assays demonstrate no significant effect of MBOA on sporulation of S. nodorum in vivo.

Fig. S4 Metabolite profiling of S. nodorum grown in the presence of MBOA.

Fig. S5 The abundance of serotonin derivatives differ in the presence of multiple effector–susceptibility gene interactions.

nph12356-sup-0002-TableS1.xlsxapplication/msexcel77KTable S1 LC-MS profiling of metabolite changes induced by SnToxA infiltration