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Fig. S1 Chemical structure of auxins and auxin analogues used in this study.

Fig. S2 Metabolic profile of indole-3-butyric acid (IBA) in tobacco BY-2 suspension-grown cells.

Fig. S3 Representative curves depicting the accumulation of auxins and auxin analogues in tobacco BY-2 cells.

Fig. S4 Active transport of auxin and its analogues across the plasma membrane in Arabidopsis thaliana, ecotype Landsberg erecta cells.

Fig. S5 Representative curves depicting the accumulation of auxins and auxin analogues in Arabidopsis thaliana, ecotype Landsberg erecta cells.

Fig. S6 Activity of auxins and auxin analogues in the stimulation of DR5-driven gene expression at higher concentration and prolonged treatment.

Fig. S7 Activity of naphthalene-1-acetic acid (NAA) and naphthalene-2-acetic acid (2-NAA) in the inhibition of endocytosis at different concentrations.