- Top of page
- Obesity and Type 2 Diabetes among Children and Adolescents in the United States
- Concept of Developmental Overnutrition
- Effects on Childhood Adiposity
- Effects on Childhood Type 2 Diabetes
- Associations Reflect Specific Intrauterine Effects
- Potential Mechanisms
- Public Health Consequences
- Postnatal Modification of Effects
- How Can These Effects be Prevented?
- Future Research Directions
Childhood obesity continues to be a significant public health burden. Empirical evidence has begun to identify intrauterine and postnatal pathways that increase the likelihood of excess adiposity and increased risk of type 2 diabetes among offspring. Reviewed here is the evidence supporting a transgenerational vicious cycle that increases obesity and diabetes in offspring and contributes substantially to the increases in obesity and type 2 diabetes observed over the past several decades. The public health impact of these findings is discussed and future research opportunities are outlined.