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Figure S1Relationship between cortical cataract and high versus low intake (with or without supplements) or blood levels of vitamin C: retrospective and cross-sectional studies. *Indicates that confidence intervals were not reported in the primary publication. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S1–S10

Figure S2Relationship between cortical cataract and high versus low intake (with or without supplements) or blood levels of vitamin C: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S2,S11

Figure S3Relationship between nuclear cataract and high versus low intake (with or without supplements) of vitamin C: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S4,S6,S7,S9,S12,S13

Figure S4Relationship between nuclear cataract and high versus low blood levels of vitamin C: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S3,S5,S7,S10,S14–S16

Figure S5Relationship between nuclear cataract and high versus low intake (with or without supplements) or blood levels of vitamin C: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S11,S17–S20

Figure S6Relationship between posterior subcapsular cataract and high versus low intake or blood levels of vitamin C: retrospective and cross-sectional studies. *Indicates that confidence intervals were not reported in the primary publication. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S1,S3,S4,S6,S7,S10,S14–S16

Figure S7Relationship between “any” type of cataract and high versus low intake or blood levels of vitamin C: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S7,S10,S16,S21–S24

Figure S8Relationship between “any” type of cataract and high versus low intake (with or without supplements) of vitamin C: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S25–S27

Figure S9Relationship between cataract extraction and high versus low intake (with or without supplements) of vitamin C: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S23,S28

Figure S10Relationship between cataract extraction and high versus low intake (with or without supplements) of vitamin C: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S11,S26,S29–S32

Figure S11Relationship between cortical cataract and high versus low intake (with or without supplements) or blood levels of vitamin E: retrospective and cross-sectional studies. *Indicates that confidence intervals were not reported in the primary publication. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S3–S5,S7,S9,S10,S14,S16,S33–S35

Figure S12Relationship between cortical cataract and high versus low intake or blood levels of vitamin E: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S2,S11,S36

Figure S13Relationship between nuclear cataract and high versus low intake (with or without supplements) or blood levels of vitamin E: retrospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S3–S5,S7,S9,S10,S13,S16,S33

Figure S14Relationship between nuclear cataract and high versus low intake (with or without supplements) or blood levels of vitamin E: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S11,S17–S20,S34

Figure S15Relationship between posterior subcapsular cataract and high versus low intake or blood levels of vitamin E: retrospective and cross-sectional studies. *Indicates that confidence intervals were not reported in the primary publication. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S1,S3,S4,S7,S10,S14,S16,S33,S37

Figure S16Relationship between mixed cataract and high versus low intake or blood levels of vitamin E: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S4,S16

Figure S17Relationship between mixed or “any” type of cataract and high versus low intake (with or without supplements) of vitamin E: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S25,S27,S38

Figure S18Relationship between cataract extraction and high versus low intake (with or without supplements) of vitamin E: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S23,S28

Figure S19Relationship between nuclear cataract and high versus low blood levels of lutein and/or zeaxanthin: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S3,S10,S16,S35,S39

Figure S20Relationship between nuclear cataract and high versus low intake or blood levels of lutein, dehydrolutein, and/or zeaxanthin: prospective studies. In each cohort, the total number of participants included in the analysis is indicated below the graph.S19,S20,S40–S43

Figure S21Relationship between “any” type of cataract and high versus low intake or blood levels of lutein and/or zeaxanthin: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S7,S10,S16,S21

Figure S22Relationship between “any” type of cataract and high versus low intake or blood levels of lutein, dehydrolutein, and/or zeaxanthin: prospective and intervention studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S38,S40,S44

Figure S23Relationship between cataract extraction and high versus low intake or blood levels of lutein, dehydrolutein, and/or zeaxanthin: prospective and intervention studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S40,S44–S46

Figure S24Relationship between cortical, nuclear, posterior subcapsular, mixed, “any” type of cataract, or cataract extraction and intake or blood levels of vitamin A or retinol: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S7,S10,S16,S47

Figure S25Relationship between cortical, nuclear, posterior subcapsular, “any” type of cataract, or extraction of cataract and high versus low intake (with or without supplements) of vitamin A or retinol: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S11,S27,S48

Figure S26Relationship between cortical cataract and high versus low intake (with or without supplements) of B vitamins: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S2,S4,S6,S9,S49

Figure S27Relationship between nuclear cataract and high versus low intake (with or without supplements) of B vitamins: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S4,S6,S9,S13,S19,S49

Figure S28Relationship between mixed or “any” type of cataract and high versus low intake or blood levels of B vitamins: retrospective, cross-sectional, and prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S4,S27,S50

Figure S29Relationship between cortical, nuclear, or posterior subcapsular cataract and B vitamin supplementation: intervention studies. In this cohort, the total number of participants (n) included in the analysis is indicated below the graph.S51

Figure S30Relationship between cortical cataract and intake or blood levels of antioxidant combinations (AOX) or multivitamin use: retrospective or cross-sectional studies. *Indicates that confidence intervals were not reported in the primary publication. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S1,S4,S5,S9,S52

Figure S31Relationship between cortical cataract or progression to cortical cataract and multivitamin use: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S2,S25,S48,S53

Figure S32Relationship between cortical cataract and supplementation with antioxidant combinations or multivitamins: intervention studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S51,S54–S56

Figure S33Relationship between nuclear cataract and high versus low intake or blood levels of antioxidant combinations (AOX) or multivitamin use: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S4,S5,S9,S13,S49,S52

Figure S34Relationship between nuclear cataract and high versus low intake of antioxidant combinations (AOX) or multivitamin use: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S17,S19,S25,S57

Figure S35Relationship between nuclear cataract and supplementation with antioxidant combinations or multivitamins: intervention studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S51,S54–S56

Figure S36Relationship between posterior subcapsular cataract and high versus low intake or blood levels of antioxidant combinations (AOX) or multivitamin use: retrospective and cross-sectional studies. *Indicates that confidence intervals were not reported in the primary publication. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S1,S4,S9,S15

Figure S37Relationship between mixed, “any” type of cataract, or extraction of cataract and high versus low intake (with or without supplements) or blood levels of antioxidant combinations (AOX) or multivitamin use: retrospective and cross-sectional studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S4,S15,S23,S58

Figure S38Relationship between cortical, nuclear, posterior subcapsular, “any” type of cataract, or extraction of cataract and high versus low intake of polyunsaturated fat: retrospective, cross-sectional, and prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S6,S27,S59–S61

Figure S39Relationship between cortical, nuclear, posterior subcapsular, “any” type of cataract, or extraction of cataract and high versus low intake of omega-3 fatty acids: prospective and intervention studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S44,S59–S61

Figure S40Relationship between cortical, nuclear, posterior subcapsular, “any” type of cataract, or extraction of cataract and high versus low intake of omega-6 fatty acids: prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S59–S61

Figure S41Relationship between cortical, nuclear, or posterior subcapsular cataract and high versus low intake of dietary protein: retrospective, cross-sectional, and prospective studies. In each cohort, the total number of participants (n) included in the analysis is indicated below the graph.S6,S27,S59

nure12077-sup-0002-ts1.docx24K

Table S1References for supplementary figures.

nure12077-sup-0003-ts2.docx35K

Table S2References for nutrients with null effect on cataract risk.

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