Dissecting impulsivity and its relationships to drug addictions

Authors

  • J. David Jentsch,

    Corresponding author
    1. Department of Psychology, University of California Los Angeles, Los Angeles, California
    • Address for correspondence: J. David Jentsch, Department of Psychology, University of California Los Angeles, Box 951563, Los Angeles, CA 90095-1563. jentsch@psych.ucla.edu

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  • James R. Ashenhurst,

    1. Interdepartmental Neuroscience Program, University of California Los Angeles, Los Angeles, California
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    • These authors contributed equally to the preparation of this manuscript and are listed in alphabetical order.

  • M. Catalina Cervantes,

    1. Department of Psychology, University of California Los Angeles, Los Angeles, California
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    • These authors contributed equally to the preparation of this manuscript and are listed in alphabetical order.

  • Stephanie M. Groman,

    1. Department of Psychology, University of California Los Angeles, Los Angeles, California
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    • These authors contributed equally to the preparation of this manuscript and are listed in alphabetical order.

  • Alexander S. James,

    1. Department of Psychology, University of California Los Angeles, Los Angeles, California
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    • These authors contributed equally to the preparation of this manuscript and are listed in alphabetical order.

  • Zachary T. Pennington

    1. Department of Psychology, University of California Los Angeles, Los Angeles, California
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    • These authors contributed equally to the preparation of this manuscript and are listed in alphabetical order.


Abstract

Addictions are often characterized as forms of impulsive behavior. That said, it is often noted that impulsivity is a multidimensional construct, spanning several psychological domains. This review describes the relationship between varieties of impulsivity and addiction-related behaviors, the nature of the causal relationship between the two, and the underlying neurobiological mechanisms that promote impulsive behaviors. We conclude that the available data strongly support the notion that impulsivity is both a risk factor for, and a consequence of, drug and alcohol consumption. While the evidence indicating that subtypes of impulsive behavior are uniquely informative—either biologically or with respect to their relationships to addictions—is convincing, multiple lines of study link distinct subtypes of impulsivity to low dopamine D2 receptor function and perturbed serotonergic transmission, revealing shared mechanisms between the subtypes. Therefore, a common biological framework involving monoaminergic transmitters in key frontostriatal circuits may link multiple forms of impulsivity to drug self-administration and addiction-related behaviors. Further dissection of these relationships is needed before the next phase of genetic and genomic discovery will be able to reveal the biological sources of the vulnerability for addiction indexed by impulsivity.

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