Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma
Article first published online: 16 APR 2014
© 2014 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1317, Steroids in Neuroendocrine Immunology and Therapy of Rheumatic Diseases I pages 57–69, May 2014
How to Cite
Mann, E. H., Chambers, E. S., Pfeffer, P. E. and Hawrylowicz, C. M. (2014), Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Annals of the New York Academy of Sciences, 1317: 57–69. doi: 10.1111/nyas.12410
- Issue published online: 31 MAY 2014
- Article first published online: 16 APR 2014
- Medical Research Council (MRC)
- Asthma U.K. Center in Allergic Mechanisms of Asthma
- MRC Centenary Fellowship. P.E.P. holds a Wellcome Trust Clinical Research Training
- vitamin D;
Vitamin D deficiency is prevalent among people with various immune-mediated conditions, including autoimmune diseases and asthma. Serum 25(OH)D levels inversely correlate with asthma severity, glucocorticoid responsiveness/dosage, and markers of pathogenesis, such as airway remodeling, IgE, and eosinophilia. Trials involving supplementation with active vitamin D or a precursor are beginning to emerge with variable results that, in part, reflect differences in study design. This review looks at the mechanisms by which vitamin D may protect against asthma, including increasing glucocorticoid responsiveness, skewing immune cells towards a regulatory phenotype, reducing the incidence of infections, airway remodeling, eosinophilia, and lowering the levels of IgE. Also discussed is the therapeutic potential for vitamin D, which is likely to be applicable to immune-mediated conditions beyond simply asthma.