Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

April 1958

Volume 68 Comparative Clinical and Biological Effects of Alkylating Agents

Pages 661–1266

    1. INTRODUCTORY REMARKS (pages 661–662)

      L. H. Schmidt

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42631.x

  1. Part I. Chemistry of Alkylating Agents

    1. Top of page
    2. Part I. Chemistry of Alkylating Agents
    3. Part II. Biological Effects of Alkylating Agents
    4. Part III. Clinical Results in Cancer
    5. Part IV. Summary Discussion
    1. FUNDAMENTAL MECHANISMS OF ALKYLATION (pages 663–668)

      Charles C. Price

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42632.x

    2. IN VITRO REACTIONS OF BIOLOGICAL ALKYLATING AGENTS (pages 669–681)

      W. C. J. Ross

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42633.x

    3. THE REACTIONS OF THE “RADIOMIMETIC” ALKYLATING AGENTS WITH MACROMOLECULES IN VITRO (pages 682–701)

      K. A. Stacey, M. Cobb, Sheila F. Cousens and P. Alexander

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42634.x

    4. DISCUSSION: PART I (pages 721–730)

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42636.x

  2. Part II. Biological Effects of Alkylating Agents

    1. Top of page
    2. Part I. Chemistry of Alkylating Agents
    3. Part II. Biological Effects of Alkylating Agents
    4. Part III. Clinical Results in Cancer
    5. Part IV. Summary Discussion
    1. MUTAGENIC EFFECTS OF ALKYLATING AGENTS (pages 731–749)

      C. Auerbach

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42637.x

    2. CARCINOGENIC ACTION OF ALKYLATING AGENTS (pages 750–761)

      Arthur L. Walpole

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42638.x

    3. PHARMACOLOGICAL AND PATHOLOGICAL EFFECTS OF ALKYLATING AGENTS (pages 811–825)

      Stephen S. Sternberg, Frederick S. Philips and Jean Scholler

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42642.x

    4. HEMATOLOGICAL EFFECTS OF THE ALKYLATING AGENTS (pages 826–833)

      L. A. Elson

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42643.x

    5. DISTRIBUTION AND FATE OF ALKYLATING AGENTS (pages 834–852)

      Paul K. Smith, M. V. Nadkarni, E. G. Trams and Clarke Davison

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42644.x

    6. TUMOR-INHIBITORY EFFECTS OF ALKYLATING AGENTS (pages 853–868)

      C. Chester Stock and Kanematsu Sugiura

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42645.x

    7. DISCUSSION: PART II (pages 868–890)

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42646.x

  3. Part III. Clinical Results in Cancer

    1. Top of page
    2. Part I. Chemistry of Alkylating Agents
    3. Part II. Biological Effects of Alkylating Agents
    4. Part III. Clinical Results in Cancer
    5. Part IV. Summary Discussion
    1. CLINICAL EVALUATION OF CB 1348 IN MALIGNANT LYMPHOMA AND RELATED DISEASES (pages 915–925)

      L. G. Israels, D. A. G. Galton, Morwenna Till and Eve Wiltshaw

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42649.x

    2. SUMMARY OF RESULTS OBTAINED WITH TEM (pages 926–936)

      R. Wayne Rundles, Evelyn V. Coonrad and Norma L. Willard

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42650.x

    3. SUMMARY OF RESULTS WITH TRIETHYLENE THIOPHOSPHORAMIDE (pages 937–966)

      Jane C. Wright, Frederick M. Golomb and Stephen L. Gumport

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42651.x

    4. BUSULFAN (1,4-DIMETHANESULFONYLOXYBUTANE, MYLERAN): SUMMARY OF CLINICAL, RESULTS (pages 967–973)

      D. A. G. Galton, Morwenna Till and Eve Wiltshaw

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42652.x

    5. CLINICAL EVALUATION OF CB 1348 IN LEUKEMIAS AND LYMPHOMAS (pages 979–995)

      Charles A. Doan, Bruce K. Wiseman and Bertha A. Bouroncle

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42654.x

    6. THERAPY OF THE MYELOPROLIFERATIVE DISORDERS WITH MYLERAN (pages 1001–1006)

      William Dameshek, Norma B. Granville and Fernando Rubio Jr.

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42656.x

    7. CHLORAMBUCIL AND TRIETHYLENE THIOPHOSPHORAMIDE IN THE TREATMENT OF NEOPLASTIC DISEASE (pages 1007–1016)

      John E. Ultmann, George A. Hyman and Alfred Gellhorn

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42657.x

    8. SUMMARY OF RESULTS OBTAINED WITH CB 1348 (pages 1024–1034)

      Stephen L. Gumport, Frederick M. Golomb and Jane C. Wright

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42660.x

    9. MYLERAN IN THE TREATMENT OF LYMPHOMAS (pages 1035–1037)

      Marguerite P. Sykes

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42661.x

    10. MYLERAN THERAPY IN BRONCHOGENIC CARCINOMA (pages 1038–1045)

      Robert D. Sullivan

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42662.x

    11. CLINICAL STUDIES OF TRIETHYLENE THIOPHOSPHORAMIDE IN THE TREATMENT OF ADVANCED NEOPLASTIC DISEASE (pages 1081–1090)

      Louis A. Leone, L. Clark Hansbarger, Eugene D. Nolley and Susan J. Mellette

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42667.x

    12. THE INTRAPERITONEAL USE OF NITROGEN MUSTARD AT THE TIME OF OPERATION FOR CANCER (pages 1097–1102)

      Steven G. Economou, Rudolph Mrazek, Gerald McDonald, Danely Slaughter and Warren H. Cole

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42669.x

    13. EARLY NITROGEN MUSTARD DERIVATIVES (pages 1103–1104)

      Joseph H. Burchenal

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42670.x

    14. CLINICAL EXPERIENCE WITH NITROMIN (pages 1105–1115)

      Yoshiyuki Koyama and Hidetaro Tokuyama

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42671.x

    15. STUDIES OF PHENYLALANINE NITROGEN MUSTARD (CB 3025) IN METASTATIC MALIGNANT MELANOMA OF MAN (pages 1122–1125)

      James F. Holland and William Regelson

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42673.x

    16. CLINICAL EXPERIENCES WITH SARCOLYSIN IN NEOPLASTIC DISEASES (pages 1128–1132)

      N. Blokhin, L. Larionov, N. Perevodchikova, L. Chebotareva and N. Merkulova

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42675.x

    17. INITIAL CLINICAL TRIAL OF THE NITROGEN MUSTARD ANALOGUES OF CHLOROQUINE AND QUINACRINE: A PRELIMINARY REPORT (pages 1133–1150)

      Ralph Jones Jr., Ulfar Jonsson, Melissa Browning, Howard Lessner, C. C. Price and A. K. Sen

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42676.x

    18. PRELIMINARY CLINICAL EVALUATION OF 1,2-BIS(β-CHLOROETHYLTHIO)ETHANE (SM-1) IN PATIENTS WITH ADVANCED LYMPHOMAS AND NEOPLASTIC DISEASES (pages 1151–1163)

      Nicholas L. Petrakis, David A. Wood, Stacy R. Mettier, Antonio V. Costantini and Seymour M. Farber

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42677.x

    19. PALLIATION OF CARCINOMATOSIS WITH ASCITES BY MEANS OF HEMISULFUR MUSTARD (pages 1181–1182)

      Arnold M. Seligman and Alexander M. Rutenburg

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42679.x

    20. OXAPENTAMETHYLENEDIETHYLENE THIOPHOSPHORAMIDE (OPSPA) IN THE TREATMENT OF HUMAN CANCER (pages 1183–1196)

      Forde A. McIver, A. R. Curreri, Francis R. Russo, Glen S. Hogle, Robert F. Schilling and Walter H. Jaeschke

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42680.x

    21. CLINICAL TRIALS OF NONANE IN MALIGNANT DISEASE (pages 1205–1210)

      Edward Miller

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42682.x

    22. THE INFLUENCE OF 1,4-DIMETHYLSULFONOXY-1,4-DIMETHYLBUTANE (CB 2348, DIMETHYL MYLERAN) IN NEOPLASTIC DISEASE (pages 1211–1222)

      H. R. Bierman, K. H. Kelly, A. G. Knudson Jr., T. Maekawa and G. M. Timmis

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42683.x

    23. PRELIMINARY STUDIES WITH SULFUR MUSTARD IN HUMAN NEOPLASTIC DISEASES (pages 1223–1224)

      Louis K. Alpert

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42684.x

  4. Part IV. Summary Discussion

    1. Top of page
    2. Part I. Chemistry of Alkylating Agents
    3. Part II. Biological Effects of Alkylating Agents
    4. Part III. Clinical Results in Cancer
    5. Part IV. Summary Discussion
    1. THE STATUS OF ALKYLATING AGENTS IN CLINICAL CANCER CHEMOTHERAPY (pages 1254–1257)

      Alfred Gellhorn

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42688.x

    2. FUTURE EXPERIMENTAL APPROACHES (pages 1258–1260)

      Alexander Haddow

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42689.x

    3. APPENDIX Structural Formulas of Principal Compounds Used Clinically (pages 1261–1266)

      David A. Karnofsky

      Version of Record online: 15 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb42690.x

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