Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1958

Volume 76 Screening Procedures for Experimental Cancer Chemotherapy

Pages 411–970

    1. INTRODUCTION (page 411)

      K. M. Endicott

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54860.x

  1. Part I. MICROBIOLOGICAL STUDIES

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. INTRODUCTORY REMARKS (page 412)

      Esmond E. Snell

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54861.x

    2. A COMPARATIVE STUDY OF THE USE OF MICROORGANISMS IN THE SCREENING OF POTENTIAL ANTITUMOR AGENTS (pages 413–441)

      G. E. Foley, R. E. McCarthy, V. M. Binns, E. E. Snell, B. M. Guirard, G. W. Kidder, V. C. Dewey and P. S. Thayer

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54862.x

    3. UTILITY OF DRUG-RESISTANT ORGANISMS IN CANCER CHEMOTHERAPY STUDIES (pages 442–456)

      F. M. Schabel Jr.

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54863.x

    4. GENERAL CONSIDERATIONS IN THE USE OF MICROORGANISMS IN SCREENING ANTITUMOR AGENTS (pages 457–468)

      S. H. Hutner, Helene A. Nathan, S. Aaronson, Herman Baker and Stanley Scher

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54864.x

    5. SPECIAL MICROBIOLOGICAL SYSTEMS, I. ANAEROBIC ORGANISMS (pages 469–474)

      William T. Bradner

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54865.x

  2. Original Article

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
  3. Part II. Normal and Malignant Cells in Tissue Culture

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. INTRODUCTION TO PART II (page 496)

      Harry Eagle

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54867.x

    2. TUMORIGENIC ACTIVITY OF CULTURES (pages 497–505)

      Alice E. Moore

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54868.x

    3. TUMORIGENIC ACTIVITY OF TISSUE CELL CULTURES (pages 506–512)

      G. E. Foley and A. H. Handler

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54869.x

    4. COMPARISON OF BIOLOGICAL QUALITIES OF “TRANSFORMED” CELLS OF NORMAL AND CANCEROUS ORIGIN (pages 513–529)

      Joseph Leighton and Richard L. Kalla

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54870.x

    5. TUMOR-SPECIFIC CYTOTOXICITY OF ANTITUMOR AGENTS (pages 530–533)

      John J. Biesele

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54871.x

    6. SUSCEPTIBILITY OF CULTURED HUMAN CELLS TO ANTITUMOR AGENTS (pages 534–541)

      Harry Eagle and George E. Foley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54872.x

    7. DISCUSSION OF PART II (pages 542–555)

      Harry Eagle

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54873.x

  4. Part III. Ascites Tumors

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. PARAMETERS OF ASCITES TUMOR GROWTH (pages 572–574)

      Harvey M. Patt

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54875.x

    2. SCREENING WITH ASCITES HEPATOMA (pages 610–618)

      Tomizo Yoshida

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54879.x

  5. Part IV. Lymphomas

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. VARIATION IN RESISTANCE PATTERNS IN DIFFERENT NEOPLASMS (pages 630–642)

      Michael Potter

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54881.x

    2. TRANSPLANTABLE LYMPHOMAS IN RATS AND RESPONSIVENESS TO DRUGS (pages 643–658)

      W. F. Dunning

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54882.x

    3. USEFULNESS OF DUNNING LEUKEMIA IRC741 FOR QUANTITATIVE PHARMACOLOGICAL STUDIES OF CANCER CHEMOTHERAPEUTIC AGENTS (pages 659–672)

      R. Jones Jr., D. McKenzie, M. L. Stevens, W. F. Dunning and M. R. Curtis

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54883.x

    4. STUDIES OF THE CULTURE OF LEUKEMIC CELLS IN VITRO (pages 673–680)

      Glenn A. Fischer

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54884.x

  6. Part V. Hormone-Responsive Tumors

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. SCREENING TECHNIQUES AND PROBLEMS OF HORMONE-RESPONSIVE TUMORS (pages 681–695)

      Jacob Furth and Kelly H. Clifton

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54885.x

    2. ESTRADIOL-SENSITIVE ISOCITRIC DEHYDROGENASE IN MAMMARY TISSUE (pages 705–712)

      Vincent P. Hollander

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54887.x

    3. HORMONAL PATTERNS AS INDICES OF TUMOR ACTIVITY (pages 713–716)

      Ralph I. Dorfman

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54888.x

    4. SCREENING HORMONAL AGENTS FOR ANTICANCER ACTIVITY IN MAN (pages 717–719)

      Albert Segaloff

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54889.x

    5. TESTING OF HORMONES AND RELATED SUBSTANCES WITH HUMAN TUMORS GROWING ON THE CHICK EMBRYO (pages 729–732)

      John J. Harris and George W. Woolley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54890.x

  7. Part VI. The Human Tumor in Heterologous Hosts

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. THE TRANSPLANTABLE HUMAN TUMOR (pages 733–741)

      Helene Wallace Toolan

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54891.x

    2. THE HUMAN TUMOR IN CANCER CHEMOTHERAPY IN THE CONDITIONED RAT (pages 742–751)

      M. N. Teller, P. C. Merker, J. E. Palm and G. W. Woolley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54892.x

    3. OBSERVATIONS ON CHEMOTHERAPY OF HUMAN TUMORS HS 1 AND HEp 3 IN THE HETEROLOGOUS HOST (pages 752–763)

      William S. Marsh and Mary Rose Cullen

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54893.x

    4. THE HUMAN TUMOR GROWN IN THE EGG (pages 764–774)

      John J. Harris

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54894.x

    5. THE HUMAN TUMOR IN THE MOUSE (pages 791–796)

      Ruth Gallily and George W. Woolley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54896.x

    6. SUCCESSFUL INTRAMUSCULAR GROWTH OF HUMAN TUMOR IN CONDITIONED MICE (pages 797–811)

      Shozo Takayama and George W. Woolley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54897.x

    7. HOST CONDITIONING IN EXPERIMENTAL CHEMOTHERAPY (pages 812–820)

      Joy E. Palm, Morris N. Teller, Philip C. Merker and George W. Woolley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54898.x

    8. DISCUSSION OF PART VI (pages 821–825)

      George W. Woolley

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54899.x

  8. Part VII. Special Systems

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. THE UTILITY OF RESISTANT LEUKEMIAS IN SCREENING FOR CHEMOTHERAPEUTIC ACTIVITY (pages 826–837)

      Joseph H. Burchenal and Ezequiel A. D. Holmberg

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54900.x

    2. CHARACTERIZATION OF THE SPECIFICITY OF ACTION OF TUMOR-INHIBITING COMPOUNDS (pages 838–849)

      P. Loustalot, P. A. Desaulles and R. Meier

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54901.x

    3. TRIAL OF CHEMOTHERAPEUTIC AGENTS IN SPONTANEOUS TUMORS IN DOGS (pages 850–854)

      John R. McCoy

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54902.x

    4. POSSIBLE UTILITY OF THE ROUS SARCOMA FOR ANTITUMOR SCREENING (pages 861–869)

      Irving S. Johnson, Linville A. Baker and Howard F. Wright

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54904.x

    5. THE USE OF ASCITES TUMORS IN SOLID AGAR FOR SCREENING OF CANCER CHEMOTHERAPEUTIC AGENTS (pages 870–881)

      Joseph A. DiPaolo and George E. Moore

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54905.x

    6. ROLE OF CHANCE OBSERVATIONS IN CHEMOTHERAPY: VINCA ROSEA (pages 882–894)

      R. L. Noble, C. T. Beer and J. H. Cutts

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54906.x

  9. Part VIII. Considerations in Experimental Cancer Chemotherapy

    1. Top of page
    2. Part I. MICROBIOLOGICAL STUDIES
    3. Original Article
    4. Part II. Normal and Malignant Cells in Tissue Culture
    5. Part III. Ascites Tumors
    6. Part IV. Lymphomas
    7. Part V. Hormone-Responsive Tumors
    8. Part VI. The Human Tumor in Heterologous Hosts
    9. Part VII. Special Systems
    10. Part VIII. Considerations in Experimental Cancer Chemotherapy
    1. INTRODUCTION TO PART VIII (page 895)

      John T. Litchfield Jr.

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54907.x

    2. STATISTICAL PROBLEMS IN A MASS SCREENING PROGRAM (pages 896–908)

      Peter Armitage and Marvin A. Schneiderman

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54908.x

    3. AN EXPERIMENTAL DESIGN IN COMBINATION CHEMOTHERAPY (pages 909–931)

      Nathan Mantel

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54909.x

    4. FACTORS INFLUENCING ANTITUMOR SYNERGISM: RELATION TO SCREENING METHODOLOGY (pages 932–938)

      Abraham Goldin, Stewart R. Humphreys, John M. Venditti and Nathan Mantel

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54910.x

    5. EXTRAPOLATION TO STUDIES IN MAN (pages 939–949)

      Louis Lasagna

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54911.x

    6. DISCUSSION OF PART VIII (pages 950–951)

      John T. Litchfield Jr.

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54912.x

    7. SUMMARY OF THE MONOGRAPH (pages 961–964)

      C. Chester Stock

      Version of Record online: 22 DEC 2006 | DOI: 10.1111/j.1749-6632.1958.tb54914.x

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