Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

March 1965

Volume 123 Evaluation and Mechanisms of Drug Toxicity

Pages 3–365

    1. INTRODUCTORY REMARKS (pages 3–4)

      J. J. Burns

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12240.x

  1. PART I. THE BASIS OF SELECTIVE TOXICITY

    1. Top of page
    2. PART I. THE BASIS OF SELECTIVE TOXICITY
    3. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS
    4. PART III. GENETIC FACTORS IN DRUG TOXICITY
    5. PART IV. DRUGS AND THE MAMMALIAN EMBRYO
    6. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS
    7. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY
    1. FUNDAMENTAL ASPECTS OF SELECTIVE TOXICITY (pages 5–18)

      Adrien Albert

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12241.x

    1. SOME MECHANISMS INVOLVED IN SELECTIVE CHEMOTHERAPY (pages 19–41)

      Arnold D. Welch

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12242.x

    2. THE BIOCHEMICAL BASIS OF AN ALLERGIC DRUG RESPONSE (pages 55–63)

      Charles W. Parker

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12244.x

    3. CLOSING REMARKS (page 78)

      F. E. Shideman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12246.x

  2. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS

    1. Top of page
    2. PART I. THE BASIS OF SELECTIVE TOXICITY
    3. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS
    4. PART III. GENETIC FACTORS IN DRUG TOXICITY
    5. PART IV. DRUGS AND THE MAMMALIAN EMBRYO
    6. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS
    7. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY
    1. DRUG-INDUCED CHANGES IN STEROID METABOLISM (pages 98–109)

      A. H. Conney, K. Schneidman, M. Jacobson and R. Kuntzman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12248.x

    2. THE INFLUENCE OF ENTEROHEPATIC CIRCULATION ON TOXICITY OF DRUGS (pages 110–124)

      R. T. Williams, P. Millburn and R. L. Smith

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12249.x

    3. METABOLISM OF DRUGS IN RELATION TO CARCINOGENICITY (pages 125–140)

      James A. Miller and Elizabeth C. Miller

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12250.x

    4. RELATIONSHIP OF DRUG METABOLISM TO METHEMOGLOBIN FORMATION (pages 141–155)

      Manfred Kiese

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12251.x

    5. CLOSING REMARKS (pages 163–166)

      Kenneth P. DuBois

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12253.x

  3. PART III. GENETIC FACTORS IN DRUG TOXICITY

    1. Top of page
    2. PART I. THE BASIS OF SELECTIVE TOXICITY
    3. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS
    4. PART III. GENETIC FACTORS IN DRUG TOXICITY
    5. PART IV. DRUGS AND THE MAMMALIAN EMBRYO
    6. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS
    7. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY
    1. THE GENETICS OF ABNORMAL DRUG RESPONSES (pages 167–177)

      Arno G. Motulsky

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12254.x

    1. DEFECTS OF HEMOGLOBIN AND OF METHEMOGLOBIN REDUCTASE (pages 207–211)

      J. Liddell and H. Lehmann

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12258.x

    2. DOSE-RESPONSE RELATIONSHIPS AND GENETIC VARIATION (pages 212–218)

      W. Kalow

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12259.x

  4. PART IV. DRUGS AND THE MAMMALIAN EMBRYO

    1. Top of page
    2. PART I. THE BASIS OF SELECTIVE TOXICITY
    3. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS
    4. PART III. GENETIC FACTORS IN DRUG TOXICITY
    5. PART IV. DRUGS AND THE MAMMALIAN EMBRYO
    6. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS
    7. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY
    1. EMBRYOLOGICAL CONSIDERATIONS IN TERATOLOGY (pages 219–227)

      James G. Wilson

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12260.x

    1. EPIDEMIOLOGY OF CONGENITAL MALFORMATIONS (pages 228–236)

      Widukind Lenz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12261.x

    2. PLACENTAL TRANSFER OF DRUGS (pages 237–244)

      Claude A. Villee

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12262.x

    3. HEPATIC DRUG METABOLISM DURING THE PERINATAL PERIOD (pages 245–251)

      James R. Fouts and Larry G. Hart

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12263.x

    4. BIOCHEMICAL EFFECTS OF DRUGS ON THE MAMMALIAN CONCEPTUS (pages 252–262)

      H. Keberle, P. Loustalot, R. K. Maller, J. W. Faigle and K. Schmid

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12264.x

    5. CLOSING REMARKS (pages 263–265)

      Earl H. Dearborn

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12265.x

  5. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS

    1. Top of page
    2. PART I. THE BASIS OF SELECTIVE TOXICITY
    3. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS
    4. PART III. GENETIC FACTORS IN DRUG TOXICITY
    5. PART IV. DRUGS AND THE MAMMALIAN EMBRYO
    6. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS
    7. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY
    1. OPENING REMARKS (pages 266–267)

      Alfred Gilman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12266.x

    1. PREDICTABILITY OF CONVENTIONAL ANIMAL TOXICITY TESTS (pages 268–272)

      John T. Litchfield Jr.

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12267.x

    2. APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES (pages 273–286)

      J. J. Burns, S. A. Cucinell, R. Koster and A. H. Conney

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12268.x

    3. EXPERIMENTAL INVESTIGATION OF TERATOGENIC ACTION (pages 287–294)

      Harold Kalter

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12269.x

  6. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY

    1. Top of page
    2. PART I. THE BASIS OF SELECTIVE TOXICITY
    3. PART II. METABOLIC ASPECTS OF THE TOXICITY OF DRUGS
    4. PART III. GENETIC FACTORS IN DRUG TOXICITY
    5. PART IV. DRUGS AND THE MAMMALIAN EMBRYO
    6. PART V. APPLICATIONS OF NEW KNOWLEDGE TO TOXICITY TESTS IN ANIMALS
    7. PART VI. CLINICAL ASPECTS OF DRUG TOXICITY
    1. DRUG TOXICITY IN MAN: THE PROBLEM AND THE CHALLENGE (pages 312–315)

      Louis Lasagna

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12271.x

    1. DRUGS AND THE KIDNEY (pages 326–332)

      George E. Schreiner and John F. Maher

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12273.x

    2. CARDIOVASCULAR TOXICITY (pages 333–341)

      Leon I. Goldberg and Nanette Kass Wenger

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12274.x

    3. NERVOUS SYSTEM REACTIONS TO DRUGS (pages 342–353)

      Leo E. Hollister

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12275.x

    4. CUTANEOUS ASPECTS OF DRUG TOXICITY (pages 354–365)

      Rudolf L. Baer

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1965.tb12276.x

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