Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

March 1968

Volume 148 Diabetes Mellitus and Obesity: Phenformin Hydrochloride as a Research Tool

Pages 575–962

    1. INTRODUCTION (page 575)

      T. S. Danowski

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27731.x

  1. PART I. THEBACKGROUNDOF THE BIGUANIDES

    1. Top of page
    2. PART I. THEBACKGROUNDOF THE BIGUANIDES
    3. PART II. THEMETABOLIC EFFECTSOF PHENFORMIN-LABORATORYSTUDIES
    4. PART III. THE METABOLIC ACTIONS OF PHENFORMIN-CLINICAL STUDIES
    5. PART IV. PHENFORMIN AS A THERAPEUTIC AGENT
    1. CHEMISTRY OF THE BIGUANIDES (pages 577–586)

      Bill Elpern

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27732.x

    1. ANTIMICROBIAL ACTIVITIES OF BIGUANIDES (pages 587–600)

      Eugene D. Weinberg

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27733.x

  2. PART II. THEMETABOLIC EFFECTSOF PHENFORMIN-LABORATORYSTUDIES

    1. Top of page
    2. PART I. THEBACKGROUNDOF THE BIGUANIDES
    3. PART II. THEMETABOLIC EFFECTSOF PHENFORMIN-LABORATORYSTUDIES
    4. PART III. THE METABOLIC ACTIONS OF PHENFORMIN-CLINICAL STUDIES
    5. PART IV. PHENFORMIN AS A THERAPEUTIC AGENT
    1. TISSUE DISTRIBUTION AND EXCRETION OF PHENFORMIN IN NORMAL AND DIABETIC ANIMALS (pages 601–611)

      H. Hall, G. Ramachander and J. M. Glassman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27734.x

    1. INHIBITION OF HEPATIC GLUCONEOGENESIS IN GUINEA PIG BY PHENFORMIN (pages 612–622)

      Ruth A. Altschuld and Fred A. Kruger

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27735.x

    2. IN VITRO EFFECTS OF PHENFORMIN HYDROCHLORIDE: OBSERVATIONS USING ISOLATED FAT CELLS (pages 623–630)

      Daniel B. Stone and Joseph D. Brown

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27736.x

    3. INHIBITION OF LIPID BIOSYNTHESIS (pages 631–646)

      Mary E. Dempsey

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27737.x

    4. PHENFORMIN-INDUCED WEIGHT LOSS IN OBESE MICE (pages 647–652)

      Samuel H. Waxier and Mary R. Leef

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27738.x

    5. LACTIC ACID TOLERANCE IN PHENFORMIN-TREATED ANIMALS (pages 653–661)

      G. Ramachander, F. Finkelman, H. Li, J. M. Glassman and H. S. Sadow

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27739.x

    6. EFFECT OF PHENFORMIN ON THE ELEVATED BLOOD LACTIC ACID PRODUCED BY HYPOXIA IN NORMAL AND DIABETIC RATS (pages 662–670)

      Thomas N. Ruggles, Marc H. Lavietes, Max Miller, Hiram Woodward Jr and Michael Treister

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27740.x

    7. PROPHYLAXIS OF OXYGEN DEPRIVATION IN RATS AT SIMULATED HIGH ALTITUDE (pages 671–690)

      Robert L. Powell and Joseph P. Buckley

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27741.x

    8. FIBRINOLYTIC STUDIES WITH BIGUANIDE DERIVATIVES (pages 691–713)

      N. Back, H. Wilkens, B. Barlow and J. Czarnecki

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27742.x

    9. THE EFFECTS OF BIGUANIDES ON THE REACTIONS OF THROMBIN AND ON THE ONE-STAGE PROTHROMBIN TIME OF STANDARD HUMAN PLASMA (pages 714–723)

      Phyllis S. Roberts and Rosalind K. Burkat

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27743.x

  3. PART III. THE METABOLIC ACTIONS OF PHENFORMIN-CLINICAL STUDIES

    1. Top of page
    2. PART I. THEBACKGROUNDOF THE BIGUANIDES
    3. PART II. THEMETABOLIC EFFECTSOF PHENFORMIN-LABORATORYSTUDIES
    4. PART III. THE METABOLIC ACTIONS OF PHENFORMIN-CLINICAL STUDIES
    5. PART IV. PHENFORMIN AS A THERAPEUTIC AGENT
    1. GLUCOSE KINETICS BEFORE AND AFTER PHENFORMIN IN THE HUMAN SUBJECT (pages 734–742)

      G. L. Searle and R. R. Cavalieri

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27745.x

    2. KINETICS OF GLUCOSE UTILIZATION IN OBESITY: THE EFFECT OF PHENFORMIN (pages 743–755)

      Robert A. Kreisberg

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27746.x

    3. DISCUSSION OF THE PAPER (pages 754–755)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27747.x

    4. EFFECTS OF PHENFORMIN ON INSULIN RESERVE AND RELEASE (pages 756–767)

      B. R. Boshell, R. F. Roddam and G. L. McAdams

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27748.x

    5. INSULIN RESPONSE TO GLUCOSE IN THE PRESENCE OF ORAL HYPOGLYCEMICS (pages 768–777)

      R. A. Arky and E. A. Abramson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27749.x

    6. COMBINED SULFONYLUREA-PHENFORMIN THERAPY OF THE DYSINSULINISM OF EARLY DIABETES MELLITUS (pages 778–786)

      Edward S. Horton, Bagher M. Sheikholislam and Rubin Bressler

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27750.x

    7. PLASMA FUCOSE AND FUCOSE TOLERANCE IN DIABETES MELLITUS (pages 787–795)

      Ralph A. Shaw, Leonard J. Kryston and Lewis C. Mills

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27751.x

    8. PLASMA GROWTH HORMONE DURING GLUCOSE LOADING IN DIABETES OR OBESITY (pages 796–807)

      T. S. Danowski, D. H. Mintz, J. Finster, G. Sabeh and C. R. Morgan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27752.x

    9. OBESITY WITHOUT DIABETES: GLUCOSE LOADS AND INSULIN LEVELS (pages 808–812)

      T. S. Danowski, C. R. Morgan, C. H. McGowen, J. H. Sunder and T. J. Robbins

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27753.x

    10. ORAL HYPOGLYCEMIC THERAPY AND ASSOCIATED HYPOTHYROIDISM (pages 813–819)

      Guy Lacy Schless and Charles T. Lee Jr

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27754.x

    11. THE FATE OF BIGUANIDES IN MAN (pages 820–832)

      Rüdiger Beckmann

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27755.x

    12. CUTANEOUS EXTRACELLULAR GLUCOSE KINETICS IN ACNE PATIENTS RECEIVING PHENFORMIN (pages 833–839)

      Donald R. Mclntyre, John A. Johnson and Ramon M. Fusaro

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27756.x

    13. FIBRINOLYTIC EFFECT OF BIGUANIDES (pages 840–847)

      G. R. Fearnley, R. Chakrabarti, Elizabeth D. Hocking and J. Evans

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27757.x

  4. PART IV. PHENFORMIN AS A THERAPEUTIC AGENT

    1. Top of page
    2. PART I. THEBACKGROUNDOF THE BIGUANIDES
    3. PART II. THEMETABOLIC EFFECTSOF PHENFORMIN-LABORATORYSTUDIES
    4. PART III. THE METABOLIC ACTIONS OF PHENFORMIN-CLINICAL STUDIES
    5. PART IV. PHENFORMIN AS A THERAPEUTIC AGENT
    1. THE COURSE OF LATENT DIABETES (pages 848–858)

      Douglas L. Wilansky and Gina Shochat

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27758.x

    1. EFFECT OF PHENFORMIN ON THE CORTISONE GLUCOSE TOLERANCE TEST (pages 859–867)

      Sheldon Berger, James L. Downey and Howard S. Traisman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27759.x

    2. FUNCTIONAL HYPOGLYCEMIA IN EARLY LATENT DIABETES (pages 868–874)

      Georgina Faludi, Gordon Bendersky and Philip Gerber

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27760.x

    3. THE RELATIONSHIP OF TREATMENT TO WEIGHT IN A RANDOMIZED STUDY OF MATURITY-ONSET DIABETES (pages 875–883)

      Curtis L. Meinert and Theodore B. Schwartz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27761.x

    4. PHENFORMIN EFFECT ON BODY WEIGHT, LIPIDS, AND GLUCOSE REGULATION (pages 884–891)

      Seymour L. Alterman and Alfredo A. Lopez-Gomez

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27762.x

    5. PHENFORMIN IN HUMAN OBESITY (pages 892–896)

      Martin S. Roginsky and Jacqueline Sandler

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27763.x

    6. SOME RESULTS OF LONG-TERM USE OF PHENFORMIN IN KETOACIDOSIS- RESISTANT DIABETES (pages 897–905)

      L. S. Craig, S. Waxier and R. Noble

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27764.x

    7. REFRACTORY OBESITY AND DIABETES (pages 906–913)

      Garfield G. Duncan, Theodore G. Duncan and Joseph Schatanoff

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27765.x

    8. INFLUENCE OF HYPOGLYCEMIC AGENTS ON BLOOD LIPIDS AND BODY WEIGHT IN KETOACIDOSIS-RESISTANT DIABETICS (pages 914–924)

      Herbert Gershberg, Zenaida Javier, Mildred Hulse and Arthur Hecht

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27766.x

    9. HYPERLIPIDEMIA (pages 925–936)

      Louis E. Schaefer

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27767.x

    10. METABOLIC ABNORMALITIES IN PREMATURE CORONARY DISEASE: EFFECTS OF THERAPY (pages 945–957)

      M. Tzagournis, J. F. Seidensticker and G. J. Hamwi

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27769.x

    11. CONCLUDING REMARKS (pages 958–962)

      T. S. Danowski

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1968.tb27770.x

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