Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

October 1969

Volume 160 The Pharmacological and Chemotherapeutic Properties of Niridazole and Other Antischistomal Compounds

Pages 427–945

    1. INTRODUCTION (pages 427–428)

      Frans C. Goble

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15866.x

  1. Part I. Experimental Chemotherapy

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. LABORATORY EVALUATION OF ANTISCHISTOSOMAL AGENTS (pages 429–460)

      J. Pellegrino and Naftale Katz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15867.x

    2. PRELIMINARY STUDIES ON PROPHYLAXIS, DRUG RESISTANCE, AND SYNERGISM IN EXPERIMENTAL SCHISTOSOMIASIS (pages 461–485)

      A. H. Mousa, A. El-Garem, E. H. El-Raziky, A. A. El-Latif, A. Selim, S. A. Wassef, A. Habib and A. El-Shenawy

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15868.x

    3. THE SIGNIFICANCE OF BLACK EGGS IN SCHISTOSOMIASIS (pages 486–490)

      Claude R. Lambert

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15869.x

    4. THE EFFECTS OF NIRIDAZOLE IN EXPERIMENTAL SCHISTOSOMIASIS (pages 491–518)

      Heini P. Striebel

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15870.x

  2. Part II. Chemistry and Metabolic Chemistry

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. CHEMISTRY OF SCHISTOSOMICIDES (pages 519–529)

      Howard W. Bond

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15871.x

    2. NITROHETEROCYCLES WITH ANTIPARASITIC EFFECTS (pages 530–535)

      P. Schmidt, K. Eichenberger, A. O. Ilvespää and M. Wilhelm

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15872.x

    3. BIOCHEMICAL EFFECTS OF SCHISTOSOMICIDES (pages 536–543)

      Ernest Bueding and Jean Fisher

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15873.x

    4. METABOLISM OF NIRIDAZOLE IN VARIOUS SPECIES, INCLUDING MAN (pages 544–557)

      J. W. Faigle and H. Keberle

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15874.x

    5. SIGNIFICANCE OF MIXED OXYGENASES AND NITROREDUCTASE IN DRUG METABOLISM (pages 558–570)

      James R. Gillette

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15875.x

  3. Part III. Clinical Trials and Evaluation

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. CLINICAL TRIALS AND DIAGNOSTIC METHODS IN SCHISTOSOMIASIS (pages 593–601)

      Dion R. Bell

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15877.x

    2. FACTORS AFFECTING RESULTS OF CHEMOTHERAPY IN SCHISTOSOMIASIS (pages 602–611)

      Peter Jordan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15878.x

    3. REVERSIBILITY OF THE UROLOGICAL LESIONS OF SCHISTOSOMIASIS IN CHILDREN AFTER SPECIFIC THERAPY (pages 629–644)

      A. O. Lucas, C. A. Akpom, W. P. Cockshott and S. P. Bohrer

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15880.x

    4. DOSAGE SCHEMES AND DOSAGE RESPONSE OF NIRIDAZOLE IN SCHISTOSOMIASIS (pages 645–649)

      V. de V. Clarke and D. M. Blair

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15881.x

    5. COMPARATIVE VALUE OF SOME CURRENTLY USED ANTISCHISTOSOMAL DRUGS (pages 650–655)

      A. W. Woodruff

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15882.x

    6. DISCUSSION (pages 656–659)

      J. E. McMahon

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15883.x

    7. CLINICAL EVALUATION OF NIRIDAZOLE IN SCHISTOSOMA MANSONI INFECTIONS (pages 660–669)

      Aluizio Prata

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15884.x

    8. INITIAL EXPERIENCES WITH NIRIDAZOLE (pages 670–685)

      Francisco Ramos-Morales, Rafael Correa-Coronas and Luis G. de Jesus

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15885.x

    9. CLINICAL EVALUATION OF NIRIDAZOLE IN SCHISTOSOMA HAEMATOBIUM AND MANSONI INFECTIONS (pages 686–695)

      A. Abdallah and M. Saif

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15886.x

    10. EFFICACY OF NIRIDAZOLE IN SCHISTOSOMIASIS HAEMATOBIUM (pages 705–712)

      M. Sankalé, R. Baylet, M. Moulanier, J. Giudicelli, R. Aury, A. Bourgeade and J. P. Ancelle

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15888.x

    11. THE RECOVERY OF ADULT SCHISTOSOMES BY EXTRACORPOREAL FILTRATION (pages 713–715)

      B. H. Kean and Edward I. Goldsmith

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15889.x

  4. Part IV. Effects on Parasites Other than Schistosomes

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. ACTIVITY OF NIRIDAZOLE IN STRONGYLOIDIASIS (pages 716–719)

      Gilbert Raffier

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15890.x

    2. ACTIVITY OF NIRIDAZOLE IN DRACONTIASIS (pages 720–728)

      Gilbert Raffier

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15891.x

    3. NIRIDAZOLE IN GUINEA WORM INFECTION (pages 729–739)

      A. O. Lucas, S. O. Oduntan and H. M. Gilles

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15892.x

    4. THE AMOEBICIDAL, TRICHOMONICIDAL, AND ANTIBACTERIAL EFFECTS OF NIRIDAZOLE IN LABORATORY ANIMALS (pages 740–748)

      F. Kradolfer, R. Jarumilinta and W. Sackmann

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15893.x

    5. THE USE OF NIRIDAZOLE ALONE AND IN COMBINATION WITH OTHER AMOEBICIDES IN AMOEBIC DYSENTERY AND AMOEBIC LIVER ABSCESS (pages 749–754)

      S. J. Powell, A. J. Wilmot and R. Elsdon-Dew

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15894.x

    6. EFFICACY OF NIRIDAZOLE IN AMOEBIC DYSENTERY (pages 755–763)

      M. Sankalé, P. Satge, M. Lariviere, M. Moulanier, A. Bourgeade, C. Debroise, J. P. Ancelle and A. M. Sow

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15895.x

    7. AMBILHAR IN AMOEBIC LIVER ABSCESS (pages 764–766)

      A. Ruas, A. Forjaz and R. Jarumilinta

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15896.x

    8. COMPARATIVE STUDY OF THE EFFECTS OF AMBILHAR AND A COMBINATION OF DEHYDROEMETINE AND CHLOROQUINE IN AMOEBIC LIVER ABSCESS (pages 767–774)

      R. Jarumilinta, C. R. Lambert, P. R. Imhof, A. Ruas and A. Forjaz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15897.x

  5. Part V. Effects on Various Organ Systems

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. FACTORS DETERMINING THE HEPATIC REACTIONS TO DRUGS (pages 775–782)

      Sheila Sherlock

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15898.x

    2. EFFECT OF SCHISTOSOMICIDES ON BONE MARROW, BLOOD CELLS, AND COAGULATION (pages 783–785)

      Marc Gentilini and Claude Carbon

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15899.x

    3. MYOCARDIAL EFFECTS OF NIRIDAZOLE (pages 799–810)

      P. Y. Hatt, B. Swynghedauw and J. C. Hayat

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15901.x

    4. RISKS VERSUS BENEFITS IN ANTISCHISTOSOMAL THERAPY (pages 811–820)

      F. Fontanilles

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15902.x

    5. DISCUSSION (pages 821–825)

      J. Rodrigues da Silva

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15903.x

  6. Part VI. Immunological Aspects

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. IMMUNITY IN SCHISTOSOMIASIS (pages 826–840)

      S. R. Smithers and R. J. Terry

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15904.x

    2. THE RELATIVE ROLE OF EGGS AND ADULT WORMS IN THE DEVELOPMENT OF LIVER DAMAGE IN MICE INFECTED WITH SCHISTOSOMA MANSONI (pages 841–862)

      E. H. Sadun, J. S. Williams, C. Witherspoon and L. K. Martin

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15905.x

    3. IMMUNOLOGICAL STUDIES IN VARIOUS TYPES OF SCHISTOSOMIASIS (pages 863–879)

      A. Capron, J. Biguet, P. Tran Van Ky and Y. Moschetto

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15906.x

  7. Part VII. Prospects for Mass Treatment and Eradication

    1. Top of page
    2. Part I. Experimental Chemotherapy
    3. Part II. Chemistry and Metabolic Chemistry
    4. Part III. Clinical Trials and Evaluation
    5. Part IV. Effects on Parasites Other than Schistosomes
    6. Part V. Effects on Various Organ Systems
    7. Part VI. Immunological Aspects
    8. Part VII. Prospects for Mass Treatment and Eradication
    1. ELIMINATION OF SCHISTOSOME PARASITES FROM MAN AND VECTOR IN A HYPERENDEMIC AREA (pages 885–914)

      Abdel-Fattah Sherif

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15908.x

    2. FIELD STUDIES IN RHODESIA (pages 915–929)

      D. M. Blair and V. de V. Clarke

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15909.x

    3. TREATMENT OF VESICAL SCHISTOSOMIASIS WITH AMBILHAR (pages 930–932)

      A. Ruas

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15910.x

    4. TREATMENT OF SCHISTOSOMIASIS JAPONICA WITH NIRIDAZOLE (pages 933–945)

      Muneo Yokogawa, Motohito Sano, Moriyasu Tsuji, Somei Kojima, Toshihiko Iijima and Yoichi Ito

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1969.tb15911.x

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