Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

November 1971

Volume 186 Folate Antagonists as Chemotherapeutic Agents

Pages 5–519

    1. INTRODUCTION (pages 5–6)

      Joseph R. Bertino

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46951.x

  1. Part I. Folate Compounds—Chemistry and Enzymology

    1. Top of page
    2. Part I. Folate Compounds—Chemistry and Enzymology
    3. Part II. Dihydrofolate Reductase
    4. Part III. Design and Synthesis of Folate Antagonists
    5. Part IV. Cytotoxic Mechanisms of Folate Antagonists
    6. Part V. Pharmacologic Considerations
    7. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists
    1. NATURALLY OCCURRING FOLATES (pages 7–28)

      Charles M. Baugh and Carlos L. Krumdieck

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46952.x

    2. SOME ASPECTS OF THE CHEMISTRY OF THE FOLATE MOLECULE (pages 29–42)

      John M. Whiteley

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46953.x

    3. PROTON MAGNETIC RESONANCE STUDIES OF FOLATE AND FOLATE ANTAGONISTS (pages 43–54)

      Edward J. Pastore

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46954.x

    4. REGULATION OF FOLATE-DEPENDENT ENZYMES (pages 55–69)

      Robert Silber and Ali Mansouri

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46955.x

    5. THE ROLE OF FOLATE COENZYMES IN THE INITIATION OF PROTEIN SYNTHESIS (pages 70–81)

      Herbert W. Dickerman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46956.x

    6. DISCUSSION (pages 82–84)

      Raymond L. Blakley and Herbert Weissbach

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46957.x

  2. Part II. Dihydrofolate Reductase

    1. Top of page
    2. Part I. Folate Compounds—Chemistry and Enzymology
    3. Part II. Dihydrofolate Reductase
    4. Part III. Design and Synthesis of Folate Antagonists
    5. Part IV. Cytotoxic Mechanisms of Folate Antagonists
    6. Part V. Pharmacologic Considerations
    7. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists
    1. Dihydrofolate Reductases: Structural and Mechanistic Aspects (pages 85–99)

      F. M. Huennekens, R. B. Dunlap, J. H. Freisheim, L. E. Gundersen, N. G. L. Harding, S. A. Levison and G. P. Mell

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46958.x

    2. DISCUSSION PAPER: ISOELECTRIC FOCUSING STUDIES ON DIHYDROFOLIC REDUCTASE (pages 100–106)

      Bernard T. Kaufman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46959.x

    3. DISCUSSION PAPER: BACTERIOPHAGE-INDUCED DIHYDROFOLATE REDUCTASE (pages 107–112)

      Christopher K. Mathews

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46960.x

    4. DISCUSSION PAPER: QUINONOID DIHYDROPTERIN REDUCTASE (pages 115–118)

      K. G. Scrimgeour and Surinder Cheema

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46962.x

    5. KINETIC STUDIES OF THE REACTION MECHANISM OF DIHYDROFOLATE REDUCTASE (pages 119–130)

      R. L. Blakley, Mary Schrock, Kathleen Sommer and P. F. Nixon

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46963.x

    6. DISCUSSION PAPER: KINETIC INVESTIGATION OF THE REACTION MECHANISM OF DIHYDROFOLATE REDUCTASE FROM L1210 CELLS (pages 131–142)

      Jerry L. McCullough, Peter F. Nixon and Joseph R. Bertino

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46964.x

    7. COMPARATIVE BIOCHEMISTRY OF DIHYDROFOLATE REDUCTASE (pages 143–152)

      James J. Burchall

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46965.x

    8. THYMIDYLATE SYNTHETASE AND ITS RELATIONSHIP TO DIHYDROFOLATE REDUCTASE (pages 153–165)

      R.B. Dunlap, N.G.L. Harding and F.M. Huennekens

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46966.x

    9. DISCUSSION PAPER: THE APPARENT INDUCTION OF THYMIDYLATE SYNTHETASE BY AMETHOPTERIN (pages 168–171)

      Frank Maley and Gladys F. Maley

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46968.x

    10. STABILIZATION OF DIHYDROFOLATE REDUCTASE BY INHIBITORS IN VIVO AND IN VITRO (pages 187–205)

      Brian L. Hillcoat, L. Marshall, J. Gauldie and M. Hiebert

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46972.x

    11. DISCUSSION (pages 206–208)

      Morris Friedkin and Charles A. Nichol

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46973.x

  3. Part III. Design and Synthesis of Folate Antagonists

    1. Top of page
    2. Part I. Folate Compounds—Chemistry and Enzymology
    3. Part II. Dihydrofolate Reductase
    4. Part III. Design and Synthesis of Folate Antagonists
    5. Part IV. Cytotoxic Mechanisms of Folate Antagonists
    6. Part V. Pharmacologic Considerations
    7. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists
    1. EMPIRICAL VS. RATIONAL APPROACHES IN CANCER CHEMOTHERAPY (pages 209–213)

      Morris Friedkin, Elizabeth J. Crawford and Laurence T. Plante

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46974.x

    2. DEAZA ANALOGUES OF AMETHOPTERIN (METHOTREXATE) (pages 227–234)

      John A. Montgomery, Robert D. Elliott, Suzanne L. Straigh and Carroll Temple

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46976.x

    3. DISCUSSION (pages 256–257)

      John J. McCormack

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46979.x

    4. DISCUSSION PAPER: SOME BIOCHEMICAL AND PHARMACOLOGIC PROPERTIES OF AMETHOPTERIN-ALBUMIN (pages 284–286)

      Samuel A. Jacobs, Maria D'Urso-Scott and Joseph R. Bertino

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46982.x

    5. DISCUSSION (pages 287–291)

      Bill R. Baker and George A. Hitchings

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46983.x

  4. Part IV. Cytotoxic Mechanisms of Folate Antagonists

    1. Top of page
    2. Part I. Folate Compounds—Chemistry and Enzymology
    3. Part II. Dihydrofolate Reductase
    4. Part III. Design and Synthesis of Folate Antagonists
    5. Part IV. Cytotoxic Mechanisms of Folate Antagonists
    6. Part V. Pharmacologic Considerations
    7. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists
    1. ON THE NATURE OF THYMINELESS DEATH (pages 292–301)

      Seymour S. Cohen

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46984.x

    2. DISCUSSION PAPER: L-ASPARAGINASE INDUCED ALTERATION OF AMETHOPTERIN (METHOTREXATE) ACTIVITY IN MOUSE LEUKEMIA L5178Y (pages 302–311)

      Robert L. Capizzi, Wilma P. Summers and Joseph R. Bertino

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46985.x

    3. SITES OF ACTION OF AMETHOPTERIN: INTRINSIC AND ACQUIRED DRUG RESISTANCE (pages 312–324)

      K. R. Harrap, Bridget T. Hill, M. E. Furness and L. I. Hart

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46986.x

    4. EFFECT OF AMETHOPTERIN ON CELLS OF EXPERIMENTAL TUMORS (pages 325–329)

      H. Lin and W. R. Bruce

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46987.x

    5. GROWTH RATE AND CELL KILL (pages 330–342)

      William M. Hryniuk and Joseph R. Bertino

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46988.x

    6. MATHEMATICAL SIMULATION IN CHEMOTHERAPY (pages 343–358)

      William C. Werkheiser

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46989.x

    7. DISCUSSION (pages 372–377)

      R. Silber and Dorris J. Hutchison

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46993.x

  5. Part V. Pharmacologic Considerations

    1. Top of page
    2. Part I. Folate Compounds—Chemistry and Enzymology
    3. Part II. Dihydrofolate Reductase
    4. Part III. Design and Synthesis of Folate Antagonists
    5. Part IV. Cytotoxic Mechanisms of Folate Antagonists
    6. Part V. Pharmacologic Considerations
    7. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists
    1. METABOLISM OF FOLATE ANTAGONISTS (pages 378–386)

      David G. Johns and Donald M. Valerino

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46994.x

    2. TISSUE DISTRIBUTION OF FOLATE ANTAGONISTS (pages 387–399)

      Vincent T. Oliverio and Daniel S. Zaharko

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46995.x

    3. COMBINATION CHEMOTHERAPY WITH FOLATE ANTAGONISTS (pages 423–437)

      Abraham Goldin

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46997.x

    4. DISCUSSION (pages 441–443)

      David P. Rall and F. Philips

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb46999.x

  6. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists

    1. Top of page
    2. Part I. Folate Compounds—Chemistry and Enzymology
    3. Part II. Dihydrofolate Reductase
    4. Part III. Design and Synthesis of Folate Antagonists
    5. Part IV. Cytotoxic Mechanisms of Folate Antagonists
    6. Part V. Pharmacologic Considerations
    7. Part VI. Present Status And Future Prospects For Chemotherapy With Folate Antagonists
    1. FOLATE ANTAGONISTS AS ANTIBACTERIAL and ANTIPROTOZOAL AGENTS (pages 444–451)

      George H. Hitchings

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb47000.x

    2. THE EFFECT OF AMETHOPTERIN ON THE IMMUNE RESPONSE (pages 467–474)

      E. Donnall Thomas and Rainer Storb

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb47002.x

    3. NEW APPROACHES TO CHEMOTHERAPY WITH FOLATE ANTAGONISTS: USE OF LEUCOVORIN “RESCUE” AND ENZYMIC FOLATE DEPLETION (pages 486–495)

      J. R. Bertino, M. Levitt, J. L. McCullough and B. Chabner

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb47004.x

    4. DISCUSSION PAPER: NEW APPROACHES TO CHEMOTHERAPY (pages 496–500)

      Dorris J. Hutchison

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb47005.x

    5. DISCUSSION (pages 516–519)

      C. Gordon Zubrod and Joseph H. Burchenal

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1971.tb47008.x

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