Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

November 1973

Volume 226 Drug-Protein Binding

Pages 5–362

    1. INTRODUCTORY REMARKS (page 5)

      Harvey M. Solomon

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20463.x

  1. Part I. Principles and Methodology

    1. Top of page
    2. Part I. Principles and Methodology
    3. Part II. The Nature of the Binding Site
    4. Part III. Pharmacological and Toxicological Implications of Protein Binding
    5. Part IV. Modulation of Binding
    1. OVERVIEW OF DRUG-PROTEIN BINDING (pages 6–17)

      James R. Gillette

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20464.x

    2. CHARACTERIZATION OF DRUG-PROTEIN INTERACTIONS BY CLASSIC METHODS (pages 36–43)

      Milton T. Bush and John D. Alvin

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20466.x

    3. RECENT ADVANCES IN METHODOLOGY: SPECTROSCOPIC TECHNIQUES (pages 44–59)

      Colin F. Chignell

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20467.x

    4. RECENT ADVANCES IN METHODOLOGY: NUCLEAR MAGNETIC RESONANCE (pages 60–68)

      Brian D. Sykes and William E. Hull

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20468.x

    5. COMPUTER ANALYSIS OF DRUG-PROTEIN BINDING DATA (pages 69–81)

      John E. Fletcher, J. Douglas Ashbrook and Arthur A. Spector

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20469.x

    6. EFFECT OF PROTEIN BINDING ON THE DISTRIBUTION OF 5,5-DIPHENYLHYDANTOIN BETWEEN PLASMA AND RED CELLS (pages 82–87)

      P. Borondy, W. A. Dill, T. Chang, R. A. Buchanan and A. J Glazko

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20470.x

    7. GENERAL DISCUSSION (pages 88–93)

      Irving M. Klotz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20471.x

  2. Part II. The Nature of the Binding Site

    1. Top of page
    2. Part I. Principles and Methodology
    3. Part II. The Nature of the Binding Site
    4. Part III. Pharmacological and Toxicological Implications of Protein Binding
    5. Part IV. Modulation of Binding
    1. DRUG-PROTEIN BINDING IN THE NEWBORN INFANT (pages 101–114)

      Joseph Krasner, George P. Giacoia and Sumner J. Yaffe

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20473.x

    2. INFLUENCE OF DISEASE ON BINDING OF DRUGS TO PLASMA PROTEINS (pages 115–126)

      Marcus M. Reidenberg and Melton Affrime

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20474.x

    3. THE ALTERATION OF PLASMA PROTEINS IN UREMIA AS REFLECTED IN THE ABILITY TO BIND DIPHENYLHYDANTOIN (pages 127–130)

      D. W. Shoeman, D. M. Benjamin and D. L. Azarnoff

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20475.x

    4. CERTAIN ASPECTS OF DRUG BINDING TO NONPLASMA PROTEINS AS ILLUSTRATED BY STUDIES WITH CYCLIZINE, CHLORCYCLIZINE, AND POLYMYXIN B (pages 131–147)

      R. Kuntzman, M. Jacobson, I. Tsai, J. J. Burns, J. Burchall and A. Koch

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20476.x

    5. GENERAL DISCUSSION (pages 154–161)

      A. J. Glazko

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20478.x

  3. Part III. Pharmacological and Toxicological Implications of Protein Binding

    1. Top of page
    2. Part I. Principles and Methodology
    3. Part II. The Nature of the Binding Site
    4. Part III. Pharmacological and Toxicological Implications of Protein Binding
    5. Part IV. Modulation of Binding
    1. PHARMACOKINETIC CONSEQUENCES OF PLASMA PROTEIN BINDING OF DRUGS (pages 162–171)

      Paul T. Schoenemann, David W. Yesair, John J. Coffey and Francis J. Bullock

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20479.x

    2. INFLUENCE OF BINDING ON DRUG METABOLISM AND DISTRIBUTION (pages 172–194)

      Peter G. Dayton, Zafar H. Israili and James M. Perel

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20480.x

    3. INFLUENCE OF BINDING ON THE PHARMACOLOGIC ACTIVITY OF ANTIBIOTICS (pages 214–224)

      Calvin M. Kunin, William A. Craig, Margaret Kornguth and Roberta Monson

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20483.x

    4. INFLUENCE OF BINDING ON THE TOXICITY OF BILIRUBIN (pages 225–237)

      Gerard B. Odell

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20484.x

    5. A NEW APPROACH TO THE DETERMINATION OF PROTEIN-BOUND BILIRUBIN DISPLACEMENT AND ITS APPLICATIONS (pages 238–246)

      Claude B. Coutinho, Rudolph W. Lucek, Joyce A. Cheripko and Ronald Kuntzman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20485.x

    6. INFLUENCE OF FREE FATTY ACID CONCENTRATION ON DRUG BINDING TO PLASMA ALBUMIN (pages 247–258)

      Arthur A. Spector, Elsa C. Santos, J. Douglas Ashbrook and John E. Fletcher

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20486.x

    7. DISCUSSION PAPER: RESULTS WITH PROPANOLOL (pages 267–268)

      David G. Shand

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20488.x

    8. GENERAL DISCUSSION (pages 269–272)

      Harvey M. Solomon

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20489.x

  4. Part IV. Modulation of Binding

    1. Top of page
    2. Part I. Principles and Methodology
    3. Part II. The Nature of the Binding Site
    4. Part III. Pharmacological and Toxicological Implications of Protein Binding
    5. Part IV. Modulation of Binding
    1. INCREASING EXCRETION OF URATE WITH DISPLACING AGENTS IN MAN (pages 309–318)

      M. W. Whitehouse, I. Kippen, J. R. Klinenberg, L. Schlosstein, D. S. Campion and R. Bluestone

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20492.x

    2. INTERACTION OF DRUGS WITH THYROID HORMONE BINDING SITES (pages 333–340)

      Jack H. Oppenheimer

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20494.x

    3. THE INFLUENCE OF ACETYLSALICYLIC ACID ON THE BINDING OF ACETRIZOATE TO HUMAN ALBUMIN (pages 341–354)

      R. Neal Pinckard, David Hawkins and Richard S. Farr

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20495.x

    4. GENERAL DISCUSSION (pages 355–357)

      Gerhard Levy

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20496.x

    5. SUMMARY AND FUTURE DIRECTIONS FOR DRUG-PROTEIN BINDING (pages 358–362)

      Murray Weiner

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1973.tb20497.x

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