Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

January 1975

Volume 240 Recent advances in hemophilia. Part I. The molecule. Discussion paper. Basic science and practical management

Pages 5–426

    1. INTRODUCTION (pages 5–6)

      Louis M. Aledort, Marvin S. Gilbert and Samuel I. Rapaport

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53317.x

  1. PART I. THE MOLECULE

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. CHAIRMAN'S INTRODUCTORY REMARKS (page 7)

      N. Raphael Shulman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53318.x

    2. MOLECULAR STRUCTURAL STUDIES OF HUMAN FACTOR VIII (pages 8–33)

      Patrick A. MKee, Judith C. Andersen and Mary Ellen Switzer

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53319.x

    3. PROPERTIES OF BOVINE FACTOR IX (CHRISTMAS FACTOR) (pages 34–42)

      Earl W. Davie, Kazuo Fujikawa, Hisao Kato and Mark E. Legaz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53320.x

    4. ISOLATION, SUBUNIT STRUCTURE, AND PROTEOLYTIC MODIFICATION OF BOVINE FACTOR VIII (pages 43–61)

      Mark E. Legaz, Mark J. Weinstein, Charles M. Heldebrant and Earl W. Davie

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53321.x

    5. DISCUSSION PAPER: FACTOR VIII (pages 70–73)

      Edward J. Hershgold

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53323.x

    6. DISCUSSION PAPER: THE EFFECT OF CLOTTING ON STRUCTURE AND FUNCTION OF HUMAN FACTOR VIII (pages 79–83)

      Norman R. Gordon and N. Raphael Shulman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53325.x

    7. DISCUSSION PAPER: FACTOR VIII SUBUNITS (page 84)

      Leon W. Hoyer

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53326.x

    8. DISCUSSION OF PART 1 (pages 86–94)

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53327.x

  2. PART II. GENETICS

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. CHAIRMAN'S INTRODUCTORY REMARKS: DETECTION OF THE CARRIER STATE OF CLASSIC HEMOPHILIA (pages 95–96)

      Oscar D. Ratnoff and Arthur G. Steinberg

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53328.x

    2. IMPLICATIONS OF IMMUNOLOGIC METHODS FOR MEASURING ANTIHEMOPHILIC FACTOR (FACTOR VIII) (pages 97–108)

      Leon W. Hoyer and Margaret E. Rick†

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53329.x

    3. THE ROLE AND THE HAZARDS OF AMNIOCENTESIS (pages 117–120)

      Kurt Hirschhorn

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53331.x

    4. APPROACHES TO GENETIC COUNSELING (pages 132–137)

      Barton Childs

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53333.x

    5. DISCUSSION PAPER: LYONIZATION IN HEMOPHILIA: A CAUSE OF ERROR IN DIRECT DETECTION OF HETEROZYGOUS CARRIERS (pages 141–146)

      John B. Graham, Emily S. Barrow and Robert C. Elston

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53335.x

    6. DISCUSSION PAPER: PROSPECTS (pages 147–148)

      Irving Schulman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53336.x

    7. DISCUSSION OF PART II (pages 149–153)

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53337.x

  3. PART III. OUR LIQUID TISSUE

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. CHAIRMAN'S INTRODUCTORY REMARKS (page 154)

      S. N. Swisher

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53338.x

    2. BLOOD—ITS DERIVATIVES AND ITS PROBLEMS—FACTOR VIII (pages 165–171)

      Robert T. Breckenridge

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53341.x

    3. BLOOD—ITS DERIVATIVES AND ITS PROBLEMS—FACTOR IX (pages 172–180)

      Carol K. Kasper

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53342.x

    4. DISCUSSION PAPER: PERSONAL EXPERIENCE (pages 181–187)

      Benjamin Alexander

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53343.x

    5. CAN THE BLOOD-TRANSMITTED HEPATITIS PROBLEM BE SOLVED? (pages 191–200)

      Alfred M. Prince

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53345.x

    6. DELIVERY OF HEALTH CARE IN HEMOPHILIA (pages 201–207)

      Peter H. Levine

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53346.x

    7. DISCUSSION PAPER: THE RED CROSS PROGRAM (pages 208–212)

      Tibor J. Greenwalt

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53347.x

    8. DISCUSSION PAPER: OTHER POINTS (pages 213–219)

      Douglas M. N. Surgenor

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53348.x

    9. DISCUSSION OF PART III (pages 215–219)

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53349.x

  4. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. CHAIRMAN'S INTRODUCTORY REMARKS (page 220)

      Alfred H. Katz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53350.x

    2. THE HEMOPHILIAC CHILD IN SCHOOL (pages 238–245)

      Frances P. Connor

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53353.x

    3. VOCATIONAL PROBLEMS IN HEMOPHILIA (pages 246–254)

      Alfred H. Katz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53354.x

    4. DISCUSSION PAPER: DISADVANTAGES OF HOME TREATMENT (pages 255–256)

      John F. Hickman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53355.x

  5. PART V. NEW APPROACHES TO DENTISTRY

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. COCHAIRMEN'S INTRODUCTORY REMARKS (pages 257–258)

      W. P. Webster and O. N. Lucas

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53356.x

    2. NEWER APPROACHES TO DENTAL THERAPY (pages 259–262)

      Stephen J. Moss

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53357.x

    3. THE USE OF HYPNOSIS IN HEMOPHILIA DENTAL CARE (pages 263–266)

      Oscar N. Lucas

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53358.x

    4. THE THERAPEUTIC ROLE OF EPSILON-AMINOCAPROIC ACID (EACA) FOR DENTAL EXTRACTIONS IN HEMOPHILIACS (pages 267–276)

      Peter N. Walsh, Charles R. Rizza, Bruce E. Evans and Louis M. Aledort

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53359.x

    5. DISCUSSION PAPER: PRACTICAL METHODS (pages 277–283)

      Daniel T. Snyder

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53360.x

  6. PART VI. Musculoskeletal Manifestations of Hemophilia

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. INTRODUCTORY REMARKS (page 284)

      Marvin S. Gilbert

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53361.x

    2. NEW HORIZONS IN RECONSTRUCTIVE JOINT SURGERY (pages 291–294)

      Åke Ahlberg

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53363.x

    3. RECONSTRUCTIVE SURGERY IN HEMOPHILIA (pages 295–310)

      Robert B. Duthie

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53364.x

    4. CHARACTERIZING THE HEMOPHILIC PSEUDOTUMOR (pages 311–315)

      Marvin S. Gilbert

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53365.x

    5. SURGICAL AND CHEMICAL SYNOVECTOMY (pages 316–327)

      Edoardo Storti and Edoardo Ascari

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53366.x

    6. DISCUSSION PAPER: SYNOVECTOMY (pages 338–339)

      William D. Arnold

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53368.x

    7. DISCUSSION PAPER: DEGENERATIVE JOINT DISEASE (pages 340–341)

      Margaret W. Hilgartner

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53369.x

    8. DISCUSSION PAPER: HEMARTHROSIS (pages 342–343)

      S. Ross Mackay

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53370.x

    9. DISCUSSION PAPER: ORTHOTIC MANAGEMENT IN HEMOPHILIA (pages 344–348)

      Paul Schumacher

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53371.x

    10. DISCUSSION OF PART IV (pages 346–348)

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53372.x

  7. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. CHAIRMAN'S INTRODUCTORY REMARKS (page 349)

      Judith G. Pool

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53373.x

    2. CHARACTERIZATION OF FACTOR VIII ANTIBODIES (pages 350–361)

      Sandor S. Shapiro

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53374.x

    3. THEORETICAL APPROACH TO MOLECULAR BIOLOGY OF FACTOR VIII: HETEROGENEITY OF THE MOLECULE (pages 378–388)

      Harvey R. Gralnick, Sally L. Marchesi and Barry S. Coller

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53377.x

    4. FACTOR VIII ANTIBODIES: IMMUNOSUPPRESSIVE THERAPY (pages 389–399)

      David Green

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53378.x

    5. TREATMENT OF HEMOPHILIC PATIENTS WITH FACTOR VIII INHIBITOR (pages 400–404)

      Charles F. Abildgaard and Marcia Britton

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53379.x

    6. HEMOPHILIA: ACQUIRED MODIFICATIONS OF THE GENETIC DISORDER (pages 405–406)

      James W. Hampton and David Warner

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53380.x

    7. DISCUSSION PAPER: TREATMENT OF THE HEMOPHILIAC WITH ANTI-VIII (pages 407–411)

      Jessica H. Lewis and Perry B. Oskins

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53381.x

    8. PRELIMINARY TRIAL OF CYCLOPHOSPHAMIDE IN THE MANAGEMENT OF HEMOPHILIACS WITH FACTOR VIII INHIBITORS (pages 412–418)

      Z. M. Ruggeri, P. M. Mannucci, J. P. Allain and D. Frommel

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53382.x

    9. DISCUSSION OF PART VII (pages 419–420)

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53383.x

  8. CONFERENCE SUMMARY

    1. Top of page
    2. PART I. THE MOLECULE
    3. PART II. GENETICS
    4. PART III. OUR LIQUID TISSUE
    5. PART IV. PSYCHOSOCIAL IMPLICATIONS OF HEMOPHILIA
    6. PART V. NEW APPROACHES TO DENTISTRY
    7. PART VI. Musculoskeletal Manifestations of Hemophilia
    8. PART VII. MANAGING THE HEMOPHILIC PATIENT WITH INHIBITOR ANTIBODY
    9. CONFERENCE SUMMARY
    1. EPILOGUE—HEMOPHILIA IN 1974: THEORY AND PRACTICE (pages 421–426)

      K. M. Brinkhous

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb53384.x

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