Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

June 1975

Volume 256 Mechanisms of Tissue Injury with Reference to Rheumatoid Arthritis

Pages 5–450

    1. INTRODUCTORY REMARKS (pages 5–7)

      Robert J. Perper

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36030.x

  1. Part I. Immune Complexes in the Initiation of Tissue Injury

    1. Top of page
    2. Part I. Immune Complexes in the Initiation of Tissue Injury
    3. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis
    4. Part III. Migration of Cells to Sites of Tissue Injury
    5. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues
    6. Part V. Role of the Pannus in Cartilage Injury
    7. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis
    1. IMMUNE COMPLEXES IN THE INITIATION OF TISSUE INJURY: AN INTRODUCTION (pages 8–9)

      H. G. Kunkel

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36031.x

    2. LOCALIZATION OF ANTIGEN-ANTIBODY COMPLEXES IN INTRAARTICULAR COLLAGENOUS TISSUES (pages 10–24)

      T. Derek V. Cooke, Suzanne Richer, Eric Hurd and Hugo E. Jasin

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36032.x

    3. EVIDENCE FOR AN INFECTIOUS ETIOLOGY OF RHEUMATOID ARTHRITIS (pages 25–38)

      David Hamerman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36033.x

    4. PATHOGENIC MECHANISMS OF TISSUE INJURY IN PERSISTENT VIRAL INFECTIONS (pages 65–72)

      Michael B. A. Oldstone, Raymond M. Welsh and Barry S. Joseph

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36035.x

    5. INTERMEDIATE COMPLEXES FORMED BY SELF-ASSOCIATION OF IgG-RHEUMATOID FACTORS (pages 82–87)

      Richard M. Pope, David C. Teller and Mart Mannik

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36037.x

    6. ACTIVATION OF THE COMPLEMENT AND PROPERDIN SYSTEMS IN RHEUMATOID ARTHRITIS (pages 96–104)

      Shaun Ruddy and K. Frank Austen

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36039.x

  2. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis

    1. Top of page
    2. Part I. Immune Complexes in the Initiation of Tissue Injury
    3. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis
    4. Part III. Migration of Cells to Sites of Tissue Injury
    5. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues
    6. Part V. Role of the Pannus in Cartilage Injury
    7. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis
    1. T- AND B-CELL INTERACTIONS IN AUTOIMMUNE SYNDROMES (pages 105–116)

      M. D. Cooper, R. G. Keightley and S. R. Webb

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36040.x

    2. LYMPHOKINES IN RHEUMATOID SYNOVITIS (pages 117–131)

      P. Stastny, M. Rosenthal, M. Andreis, D. Cooke and M. Ziff

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36041.x

    3. THE ROLE OF LYMPHOCYTES AND MACROPHAGES IN THE DESTRUCTION OF BONE AND COLLAGEN (pages 132–140)

      Stephan E. Mergenhagen, Sharon M. Wahl, Larry M. Wahl, John E. Horton and Lawrence G. Raisz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36042.x

    4. THE ROLE OF THE LYMPHOCYTE AND ITS PRODUCTS IN THE PROPAGATION OF JOINT DISEASE (pages 150–168)

      C. M. Pearson, H. E. Paulus and H. I. Machleder

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36044.x

  3. Part III. Migration of Cells to Sites of Tissue Injury

    1. Top of page
    2. Part I. Immune Complexes in the Initiation of Tissue Injury
    3. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis
    4. Part III. Migration of Cells to Sites of Tissue Injury
    5. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues
    6. Part V. Role of the Pannus in Cartilage Injury
    7. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis
    1. PHYSIOLOGIC AND PHARMACOLOGIC ALTERATIONS OF RAT LEUKOCYTE CHEMOTAXIS (Cx) IN VIVO (pages 190–209)

      R. J. Perper, M. Sanda, V. J. Stecher and A. L. Oronsky

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36047.x

  4. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues

    1. Top of page
    2. Part I. Immune Complexes in the Initiation of Tissue Injury
    3. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis
    4. Part III. Migration of Cells to Sites of Tissue Injury
    5. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues
    6. Part V. Role of the Pannus in Cartilage Injury
    7. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis
    1. YIN/YANG MODULATION OF LYSOSOMAL ENZYME RELEASE FROM POLYMORPHONUCLEAR LEUKOCYTES BY CYCLIC NUCLEOTIDES (pages 222–232)

      Gerald Weissmann, Ira Goldstein, Sylvia Hoffstein, Geneviéve Chauvet and Roger Robineaux

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36049.x

    2. CONNECTIVE TISSUE-DEGRADING ENZYMES OF HUMAN LEUKOCYTES (pages 233–253)

      Arnold L. Oronsky and Robert J. Perper

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36050.x

    3. DISCUSSION PAPER: SUBCELLULAR LOCALIZATION AND HETEROGENEITY OF NEUTRAL PROTEASES IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES (pages 263–265)

      Marco Baggiolini, Beatrice Dewald, Rothild Rindler-Ludwig and Ursula Bretz

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36052.x

    4. BIOCHEMICAL CHARACTERISTICS OF ACTIVATED MACROPHAGES (pages 266–274)

      M. L. Karnovsky, J. Lazdins, D. Drath and A. Harper

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36053.x

    5. SUMMARY: ROLE OF INFLAMMATORY CELLS IN THE DESTRUCTION OF SYNOVIAL TISSUES (page 288)

      M. L. Karnovsky

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36055.x

  5. Part V. Role of the Pannus in Cartilage Injury

    1. Top of page
    2. Part I. Immune Complexes in the Initiation of Tissue Injury
    3. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis
    4. Part III. Migration of Cells to Sites of Tissue Injury
    5. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues
    6. Part V. Role of the Pannus in Cartilage Injury
    7. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis
    1. COLLAGENASE PRODUCTION BY HUMAN SYNOVIAL TISSUES (pages 289–303)

      Stephen M. Krane

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36056.x

    2. SYNOVIAL CELL ACTIVATION INDUCED BY A POLYPEPTIDE MEDIATOR (pages 304–317)

      C. William Castor

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36057.x

    3. PROSTAGLANDINS IN THE RHEUMATIC DISEASES (pages 318–329)

      Dwight R. Robinson, Mary B. McGuire and Lawrence Levine

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36058.x

  6. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis

    1. Top of page
    2. Part I. Immune Complexes in the Initiation of Tissue Injury
    3. Part II. Lymphocytes as Mediators of Tissue Destruction in Rheumatoid Arthritis
    4. Part III. Migration of Cells to Sites of Tissue Injury
    5. Part IV. Role of Inflammatory Cells in the Destruction of Synovial Tissues
    6. Part V. Role of the Pannus in Cartilage Injury
    7. Part VI. Prospectives on Possible Therapy for Prevention of Joint Destruction in Rheumatoid Arthritis
    1. THE CLINICAL SIGNIFICANCE OF IMMUNE COMPLEXES IN RHEUMATOID DISEASE (pages 338–341)

      Duncan A. Gordon, Barry E. Koehler, M. Lynn Russell, Murray B. Urowitz and Irvin Broder

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36060.x

    2. CYCLIC NUCLEOTIDES IN LYMPHOCYTE FUNCTION (pages 352–364)

      John W. Hadden

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36062.x

    3. SUPPRESSOR T CELLS AS REGULATORS OF LYMPHOCYTE FUNCTIONS (pages 365–374)

      Carl W. Pierce, Duane L. Peavy and Takushi Tadakuma

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36063.x

    4. ABNORMALITIES OF LEUKOCYTE CHEMOTAXIS IN HUMAN DISEASE (pages 386–401)

      Ralph Snyderman, Marilyn C. Pike and Leonard C. Altman

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36065.x

    5. SYNTHETIC ACTIVE SITE-DIRECTED INHIBITORS OF ELASTOLYTIC PROTEASES (pages 420–425)

      James C. Powers, David L. Carroll and Peter M. Tuhy

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36068.x

    6. THE EFFECT OF COMPLEMENT DEPLETION ON EXPERIMENTAL TISSUE INJURY (pages 426–440)

      Peter M. Henson and Charles G. Cochrane

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36069.x

    7. INHIBITION OF COMPLEMENT-DERIVED ENZYMES (pages 441–450)

      Douglas T. Fearon and K. Frank Austen

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1975.tb36070.x

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