Annals of the New York Academy of Sciences

© The New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

October 1977

Volume 297 ACTH and Related Peptides: Structure, Regulation, and Action

Pages 1–638

  1. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. INTRODUCTORY REMARKS (pages 1–2)

      Choh Hao Li

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41842.x

    2. ACTH: A SHORT INTRODUCTORY REVIEW (pages 3–26)

      Robert Schwyzer

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41843.x

    3. DIFFERENT MOLECULAR FORMS OF ACTH (pages 27–48)

      David N. Orth and Wendell E. Nicholson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41844.x

    4. STRUCTURE AND BIOSYNTHESIS OF PEPTIDES RELATED TO CORTICOTROPINS AND β-MELANOTROPINS (pages 49–62)

      P. J. Lowry, R. E. Silman, J. Hope and A. P. Scott

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41845.x

    5. STRUCTURE-FUNCTION RELATIONSHIPS IN LIPOTROPINS (pages 63–83)

      László Gráf, György Cseh, András Z. Rónai, József I. Székely, Ágnes Kenessey, Sándor Bajusz and Erzsébet Kenessey

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41846.x

    6. A β-LPH PRECURSOR MODEL: RECENT DEVELOPMENTS CONCERNING MORPHINE-LIKE SUBSTANCES (pages 84–105)

      M. Chrétien, N. G. Seidah, S. Benjannet, N. Dragon, R. Routhier, T. Motomatsu, P. Crine and M. Lis

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41847.x

    7. PITUITARY AND BRAIN OPIOID PEPTIDES (ENDORPHINS) (pages 108–114)

      Avram Goldstein, Brian M. Cox, Susan Gentleman, Louise I. Lowney and Alphonsus L. Cheung

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41848.x

    8. BIOLOGIC ACTIVITIES OF β-ENDORPHIN AND ITS RELATED PEPTIDES (pages 115–130)

      Horace H. Loh and Choh Hao Li

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41849.x

    9. THE ENDORPHINS, NOVEL PEPTIDES OF BRAIN AND HYPOPHYSIAL ORIGIN, WITH OPIATE-LIKE ACTIVITY: BIOCHEMICAL AND BIOLOGIC STUDIES (pages 131–157)

      Roger Guillemin, Nicholas Ling, Larry Lazarus, Roger Burgus, Scott Minick, Floyd Bloom, Roger Nicoll, George Siggins and David Segal

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41850.x

    10. ISOLATION, STRUCTURE, SYNTHESIS AND MORPHINE-LIKE ACTIVITY OF β-ENDORPHIN FROM HUMAN PITUITARY GLANDS (pages 158–166)

      Choh Hao Li, Donald Yamashiro, David Chung, Byron A. Doneen, Horace H. Loh and Liang-fu Tseng

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41851.x

  2. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. THE CELLS OF ORIGIN OF ACTH IN MAN (pages 167–181)

      Nicholas S. Halmi and Gwen C. Moriarty

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41852.x

    2. HETEROGENEITY OF ACTH-CONTAINING CELLS IN THE RAT PITUITARY, WITH EMPHASIS ON THE STRUCTURE AND FUNCTION OF THE INTERMEDIATE LOBE (pages 183–199)

      Gwen C. Moriarty

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41853.x

    3. THE ORIGIN OF ACTH CELLS IN RAT ANTERIOR PITUITARY (pages 201–204)

      P. K. Nakane, G. Sétáló and J. E. Mazurkiewicz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41854.x

  3. Part III. Assay of ACTH

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. Part III. Assay of ACTH PLASMA ACTH RADIOIMMUNOASSAYS IN THE DIAGNOSIS OF PITUITARY-ADRENAL DYSFUNCTION (pages 205–217)

      Charles D. West and Loren I. Dolman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41855.x

    2. BIOASSAY OF ACTH USING ISOLATED CORTEX CELLS APPLICATIONS: STRUCTURE ACTIVITY RELATIONSHIP FOR ACTH AND ANALOGUES, ASSAY OF CORTICOTROPIN-RELEASING FACTOR, AND ASSAY OF PLASMA ACTH (pages 220–241)

      George Sayers

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41856.x

    3. THE CYTOCHEMICAL BIOASSAY OF CORTICOTROPIN (ACTH) (pages 242–259)

      J. R. Daly, J. Alaghband-Zadeh, N. Loveridge and J. Chayen

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41857.x

    4. ASSAY OF ACTH: DISCUSSION (pages 260–262)

      David Orth

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41858.x

  4. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. BHAVIORAL EFFECTS OF NEUROPEPTIDES RELATED TO ACTH, MSH, AND βLPH (pages 263–272)

      David de Wied

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41859.x

    2. CATECHOLAMINES: EFFECTS OF ACTH AND ADRENAL CORTICOIDS (pages 275–283)

      Julius Axelrod

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41860.x

    3. DIFFERENTIAL RESPONSIVENESS OF CENTRAL NORADRENERGIC AND DOPAMINERGIC NEURON TYROSINE HYDROXYLASE TO HYPOPHYSECTOMY, ACTH, AND GLUCOCORTICOID ADMINISTRATION (pages 284–293)

      G. R. Van Loon, M. J. Sole, A. Kamble, C. Kim and S. Green

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41861.x

  5. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. Part IV. ACTH Action II. ACTH Action On The Adrenal Cortex ACTH RECEPTORS AND THE EFFECT OF ACTH ON ADRENAL ORGANELLES (pages 295–312)

      David A. Ontjes, D. Kirk Ways, Darien D. Mahaffee Carol F. Zimmerman and John T. Gwynne

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41862.x

    2. A COMPARISON OF THE EFFECTS OF ACTH, VASOACTIVE INTESTINAL PEPTIDE, AND CHOLERA TOXIN ON ADRENAL cAMP AND STEROID SYNTHESIS (pages 314–327)

      J. Kowal, I. Horst, J. Pensky and M. Alfonzo

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41863.x

    3. ACTH ACTION ON ADRENAL STEROIDOGENESIS (pages 329–335)

      Seymour B. Koritz, Girija Bhargava and Elaine Schwartz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41864.x

    4. STUDIES OF THE TROPHIC ACTION OF ACTH (pages 336–347)

      J. Ramachandran, A. Jagannadha Rao and Susanna Liles

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41865.x

    5. EFFECT OF ACTH ON CYTOCHROME P450 SYSTEMS OF THE ADRENAL CORTEX (pages 349–360)

      Alexander C. Brownie, Samuel Gallant, Douglas P. Paul, Lloyd L. Bergon, Nanette R. Orme-Johnson And and William H. Orme-Johnson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41866.x

    6. ADRENOCORTICOTROPIN AND PLASMA ALDOSTERONE CONCENTRATION AND DEOXYCORTICOSTERONE IN MAN (pages 361–369)

      Edward G. Biglieri and J. M. Lopez

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41867.x

    7. ACTH AND ALDOSTERONE: DISCUSSION (pages 370–371)

      Discussant: W. F. Ganong

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41868.x

    8. THE NEURAL REGULATION OF COMPENSATORY ADRENAL GROWTH (pages 373–392)

      Mary F. Dallman, William C. Engeland and Matilde H. McBride

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41869.x

    9. NEURAL REGULATION OF ADRENAL SIZE: DISCUSSION (pages 393–394)

      Discussant: G. Liddle

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41870.x

  6. Part V. Corticotropin-Releasing Factor

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. CORTICOTROPIN-RELEASING FACTOR: ISOLATION AND CHEMICAL PROPERTIES (pages 395–404)

      M. Saffran and A. V. Schally

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41871.x

    2. VASOPRESSIN AND CORTICOTROPIN-RELEASING FACTOR: AN AXONAL PATHWAY TO PORTAL CAPILLARIES IN THE ZONA EXTERNA OF THE MEDIAN EMINENCE CONTAINING VASOPRESSIN AND ITS INTERACTION WITH ADRENAL CORTICOIDS (pages 405–417)

      Earl A. Zimmerman, Margaret A. Stillman, Larry D. Recht, J. L. Antunes, Peter W. Carmel and Paul C. Goldsmith

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41872.x

    3. EXTRA-CNS CORTICOTROPIN-RELEASING FACTORS (pages 420–433)

      Alvin Brodish

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41873.x

    4. ASSAYS AND DYNAMICS OF CORTICOTROPIN-RELEASING FACTOR ACTIVITY IN RAT HYPOTHALAMUS (pages 436–454)

      T. Hiroshige, K. Fujieda, M. Kaneko and K. Honma

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41874.x

  7. Part VI. Regulation of ACTH Secretion

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. NURAL PATHWAYS INVOLVED IN ACTH REGULATION (pages 455–476)

      M. Palkovits

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41875.x

    2. NEURAL CONTROL OF ACTH RELEASE IN RESPONSE TO HEMORRHAGE (pages 477–496)

      Donald S. Gann, David G. Ward, Alex J. Baertschi, Drew E. Carlson and Janice W. Maran

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41876.x

    3. PLASMA ACTH LEVELS IN STRESSED AND NONSTRESSED ADRENALECTOMIZED RATS (pages 498–506)

      Ann Ruhmann-Wennhold and Don H. Nelson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41877.x

    4. NEUROTRANSMITTERS INVOLVED IN ACTH SECRETION: CATECHOLAMINES (pages 509–517)

      William F. Ganong

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41878.x

    5. SEROTONIN INVOLVEMENT IN PITUITARY-ADRENAL FUNCTION (pages 518–526)

      Joan Vernikos-Danellis, K. J. Kellar, D. Kent, C. Gonzales, P. A. Berger and J. D. Barchas

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41879.x

    6. SEROTONIN REGULATION OF ACTH SECRETION (pages 527–534)

      Dorothy T. Krieger

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41880.x

    7. NEUROTRANSMITTER REGULATION OF CORTICOTROPIN-RELEASING FACTOR IN VITRO (pages 536–558)

      Mortyn T. Jones and Edward W. Hillhouse

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41881.x

    8. REGULATION OF CIRCADIAN PERIODICITY OF PLASMA ACTH LEVELS (pages 561–566)

      Dorothy T. Krieger

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41882.x

    9. ADRENAL STEROID FEEDBACK ON NEUROENDOCRINE TISSUES (pages 568–579)

      Bruce S. McEwen

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41883.x

    10. SOME ASPECTS OF CORTICOSTEROID FEEDBACK ACTIONS (pages 580–589)

      P. G. Smelik

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41884.x

    11. REGULATION OF ACTH SECRETION: DISCUSSION (pages 591–593)

      Discussant: Donald S. Gann

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41885.x

  8. Part VII. Clinical Aspects of ACTH Regulation

    1. Top of page
    2. Part I. ACTH and Related Peptide Hormones: Chemistry, Structure-Function Relationships
    3. Part II. ACTH-Secreting Cells: Histology and Electron Microscopy
    4. Part III. Assay of ACTH
    5. Part IV. ACTH Action I. Extra-Adrenal Actions of ACTH
    6. Part IV. ACTH Action II. ACTH Action on the Adrenal Cortex
    7. Part V. Corticotropin-Releasing Factor
    8. Part VI. Regulation of ACTH Secretion
    9. Part VII. Clinical Aspects of ACTH Regulation
    1. CUSHING'S SYNDROME (pages 594–601)

      Grant W. Liddle

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41886.x

    2. ACTH AS A TUMOR MARKER (pages 603–620)

      Lesley H. Rees, Glenys A. Bloomfield, J. J. H. Gilkes, W. J. Jeffcoate and G. M. Besser

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41887.x

    3. ACTH AND CORTISOL SECRETION IN PSYCHIATRIC DISEASE (pages 621–625)

      Edward J. Sachar

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41888.x

    4. CLINICAL ASPECTS OF ACTH REGULATION: DISCUSSION (pages 628–631)

      Discussant: D. Nelson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41889.x

    5. CONFERENCE SUMMARY (pages 633–638)

      D. T. Krieger

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1977.tb41890.x

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