Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1979

Volume 332 Subcellular Factors in Immunity

Pages 1–604

  1. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. ISOLATION FROM HUMAN PLASMA OF A PROTEIN FRACTION WITH THYMIC HORMONE-LIKE ACTIVITY (pages 1–8)

      Abraham White and Pamela Burton

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47092.x

    1. BIOCHEMICAL AND BIOLOGICAL PROPERTIES OF THF IN ANIMAL AND HUMAN MODELS (pages 9–22)

      Nathan Trainin, Varda Rotter, Yeshayahu Yakir, Rena Leve, Z. Handzel, Batia Shohat and Rina Zaizov

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47093.x

    2. THE MODE OF ACTION OF THYMIC HORMONES (pages 23–32)

      Jean-François Bach, Marie-Anne Bach, Jeannine Charreire, Mireille Dardenne and Jean-Marie Pleau

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47094.x

    3. CURRENT STATUS OF THYMOSIN RESEARCH: EVIDENCE FOR THE EXISTENCE OF A FAMILY OF THYMIC FACTORS THAT CONTROL T-CELL MATURATION (pages 33–48)

      Teresa L. K. Low, Gary B. Thurman, Carolina Chincarini, John E. McClure, Gailen D. Marshall, Shu-Kuang Hu and Allan L. Goldstein

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47095.x

    4. BIOLOGICAL ACTIVITY OF THE PURE THYMUS PROTEIN, LSHr : DISCUSSION PAPER (pages 49–54)

      M. D. Pierschbacher, T. D. Luckey and J. R. Kalden

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47096.x

    5. ROLE OF A CIRCULATING THYMIC FACTOR IN SELF-RECOGNITION AND SELF-TOLERANCE : DISCUSSION PAPER (pages 55–63)

      Marie-Anne Bach and Jeannine Charreire

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47097.x

    6. THYMIC INDUCERS OF HUMAN T-LYMPHOCYTE DIFFERENTIATION IN VITRO AND IN VIVO : DISCUSSION PAPER (pages 64–69)

      Jean-Louis Touraine, Françoise Touraine and technical assistance of Odette de Bouteiller

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47098.x

  2. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. EFFECTS OF THYMOSIN ON CYTOTOXICITY AND VIRUS PRODUCTION IN AKR MICE (pages 70–80)

      Anna D. Barker, Anthony J. Dennis, Victor S. Moore and John M. Rice

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47099.x

    1. T-LYMPHOCYTE MATURATION: CELL SURFACE MARKERS AND IMMUNE FUNCTION INDUCED BY T-LYMPHOCYTE CELL-FREE PRODUCTS AND THYMOSIN POLYPEPTIDES (pages 81–94)

      Aftab Ahmed, Dennis M. Wong, Gary B. Thurman, Teresa L. K. Low, Allan L. Goldstein, Saul J. Sharkis and Irving Goldschneider

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47100.x

    2. THYMOSIN MODULATION OF SUPPRESSOR FUNCTION IN MICE AND MAN : DISCUSSION PAPER (pages 95–100)

      B. Serrou, C. Rosenfeld, J. Caraux, C. Thierry, D. Cupissol and A. Goldstein

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47101.x

    3. RELEASE OF AN Fc-BINDING COMPONENT FROM NORMAL OR ACTIVATED HUMAN LYMPHOCYTES : DISCUSSION PAPER (pages 101–108)

      Jean Caraux and Bernard Serrou

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47102.x

  3. Part III. Clinical Trials with Thymus Factors

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. IN VITRO AND IN VIVO ENHANCEMENT OF MIXED LYMPHOCYTE CULTURE REACTIVITY BY THYMOSIN IN PATIENTS WITH PRIMARY IMMUNODEFICIENCY DISEASE (pages 128–134)

      D. W. Wara, D. J. Barrett, A. J. Ammann and M. J. Cowan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47106.x

    1. EFFECTS OF THYMOSIN IN VITRO IN CANCER PATIENTS AND CORRELATION WITH CLINICAL COURSE AFTER THYMOSIN IMMUNOTHERAPY (pages 135–147)

      Paul B. Chretien, Stephen D. Lipson, Robert W. Makuch, Daniel E. Kenady and Martin H. Cohen

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47107.x

    2. CLINICAL TRIALS WITH THYMOSIN (pages 148–159)

      John Costanzi, Jerry Daniels, Gary Thurman, Allan Goldstein and James Hokanson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47108.x

    3. NEW APPROACHES TO THE EVALUATION OF IMMUNOMODULATION BY THYMIC HORMONES (pages 160–171)

      Yehuda Z. Patt, Evan M. Hersh, Marvette Adebite, Ruth Goldman and Giora Mavligit

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47109.x

    4. THE EFFECT OF THF IN LYMPHOPROLIFERATIVE AND MYELOPROLIFERATIVE DISEASES IN CHILDREN (pages 172–183)

      R. Zaizov, R. Vogel, B. Wolach, I. J. Cohen, I. Varsano, B. Shohat, Z. Handzel, V. Rotter, Y. Yakir and N. Trainin

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47110.x

  4. Part IV. RNA and Transfer Factor in Immunity

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. TRANSFER FACTOR AND IMMUNITY: AN INTRODUCTION (pages 184–186)

      S. B. Sutcliffe, G. Maziarz and A. A. Gottlieb

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47111.x

    1. RNA MODULATING SPECIFIC AND NONSPECIFIC IMMUNE RESPONSES (pages 187–195)

      Herman Friedman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47112.x

    2. IMMUNE RNA IN TUMOR IMMUNOLOGY (pages 196–206)

      David H. Kern and Yosef H. Pilch

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47113.x

    3. IMMUNOTHERAPY WITH RNA IN CANCER (pages 207–215)

      Bosco Shang Wang, Glenn Steele Jr., Suzanne R. Onikul and John A. Mannick

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47114.x

    4. NATURE AND ACTIVITIES OF TRANSFER FACTOR (pages 216–227)

      Eskild A. Petersen and Charles H. Kirkpatrick

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47115.x

    5. TRANSFER FACTOR IN IMMUNODEFICIENCY DISEASES (pages 228–235)

      Lynn E. Spitler

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47116.x

    6. A STRUCTURAL MODEL FOR HUMAN TRANSFER FACTOR : DISCUSSION PAPER (pages 236–240)

      Denis R. Burger, Pamela A. Wampler, Arthur A. Vandenbark and David H. Regan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47117.x

  5. Part V. Role of Intracellular Factors in Immunity

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. CYCLIC NUCLEOTIDES AND CALCIUM IN LYMPHOCYTE REGULATION AND ACTIVATION (pages 241–254)

      John W. Hadden, Ronald G. Coffey, Radha Ananthakrishnan and Elba M. Hadden

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47118.x

    1. ROLE OF CYCLIC NUCLEOTIDES IN REGULATING LYMPHOCYTES (pages 255–261)

      Charles W. Parker

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47119.x

    2. ENDOGENOUS PROSTAGLANDIN SYNTHESIS AND THE CONTROL OF LYMPHOCYTE FUNCTION (pages 262–270)

      David R. Webb, Thomas J. Rogers and Irene Nowowiejski

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47120.x

    3. PROSTAGLANDIN AND CYCLIC AMP REGULATION OF MACROPHAGE INVOLVEMENT IN CONNECTIVE TISSUE DESTRUCTION (pages 271–278)

      Larry M. Wahl, Charles E. Olsen, Sharon M. Wahl, James B. McCarthy, Ann L. Sandberg and Stephan E. Mergenhagen

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47121.x

    4. PROSTAGLANDINS AND THEIR REGULATION IN RHEUMATOID INFLAMMATION (pages 279–294)

      D. R. Robinson, J.-M. Dayer and S. M. Krane

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47122.x

  6. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. ROLE OF MITOGENIC FACTOR, LYMPHOCYTE-ACTIVATING FACTOR AND IMMUNE INTERFERON IN THE INDUCTION OF HUMORAL AND CELL-MEDIATED IMMUNITY (pages 303–315)

      John J. Farrar, Philip L. Simon, William L. Farrar, William J. Koopman and Janet Fuller-Bonar

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47125.x

    2. CHARACTERIZATION OF AN ANTIGEN-SPECIFIC FACTOR FROM A HYBRID T-CELL LINE (pages 316–335)

      Michael J. Taussig, José R. F. Corvalán and Andrew Holliman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47126.x

    3. ROLE OF NONSPECIFIC AND SPECIFIC SUPPRESSOR FACTORS IN IMMUNITY (pages 336–344)

      Carl W. Pierce, Takushi Tadakuma and Judith A. Kapp

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47127.x

    4. A REGULATORY ROLE FOR INTERFERON IN IMMUNITY (pages 345–355)

      Gerald Sonnenfeld and Thomas C. Merigan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47128.x

    5. REGULATION OF LYMPHOK1NE FUNCTION (pages 356–362)

      Stanley Cohen and Takeshi Yoshida

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47129.x

    6. THE GENERATION OF AN ALLOSPECIFIC SUPPRESSOR FACTOR IN CULTURE : DISCUSSION PAPER (pages 367–377)

      Avi Eisenthal, David Nachtigal and Michael Feldman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47131.x

  7. Part VII. Efferent Lymphokines Involved in Immunity

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. BIOLOGICAL EFFECTS AND CHARACTERISTICS OF ANTILYMPHOKINES (pages 408–410)

      Takeshi Yoshida and Stanley Cohen

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47134.x

    2. LYMPHOKINE MODULATION OF CONNECTIVE TISSUE METABOLISM (pages 411–422)

      S. M. Wahl and L. M. Wahl

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47135.x

    3. T-CELL GROWTH FACTOR-MEDIATED T-CELL PROLIFERATION (pages 423–432)

      Kendall A. Smith, Steven Gillis, Paul E. Baker, Douglas McKenzie and Francis W. Ruscetti

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47136.x

    4. GLUCOCORTICOSTEROID RESPONSE-MODIFYING FACTORS DERIVED FROM ACCESSORY CELLS (pages 433–445)

      Robert I. Mishell, Linda M. Bradley, Yu-hua Una Chen, Kenneth H. Grabstein and Stanley M. Shiigi

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47137.x

    5. LEUKEMIA VIRUS-INDUCED IMMUNOSUPPRESSION: REVERSAL BY SUBCELLULAR FACTORS : DISCUSSION PAPER (pages 446–450)

      R. Christopher Butler and Herman Friedman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47138.x

    6. TUMOR REGRESSION INDUCED IN MICE BY PARTIALLY PURIFIED LYMPHOKINE FRACTIONS : DISCUSSION PAPER (pages 451–459)

      B. W. Papermaster, C. D. Gilliland, M. Smith, S. Buchok, J. E. McEntire, R. C. Butler, S. Specter and H. Friedman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47139.x

  8. Part VIII. Lymphoid Cell Factors Regulating Immunity

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. A T-CELL FACTOR THAT MEASURES INTERMEDIATE STEPS IN IN VIVO IMMUNE RESPONSES (pages 460–463)

      Myron A. Leon and Tuan-Huey Kuo

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47140.x

    1. MACROPHAGE-LYMPHOCYTE INTERACTIONS MEDIATED BY SOLUBLE FACTORS (pages 464–481)

      Herbert B. Herscowitz, Kenneth J. Pennline, Robert E. Conrad, Stephen E. Ullrich and Harriet R. Gerber

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47141.x

    2. SYNTHESIS AND SECRETION OF COMPLEMENT PROTEINS BY MACROPHAGES (pages 482–490)

      Harvey R. Colten, Yuet M. Ooi and Paul J. Edelson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47142.x

    3. HUMAN T-CELL RESPONSES IN VITRO: CELL INTERACTIONS AND FACTORS (pages 503–515)

      Ann Rees, Marc Feldmann, Peter Erb, James Woody, Sirkka Kontiainen, Julia Bodmer, Fred Kantor and Nathan Zvaifler

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47144.x

    4. HELPER SIGNALS IN T-T CELL COLLABORATION (pages 516–523)

      Janet Plate†

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47145.x

    5. FACTORS FROM LYMPHOID CELL TUMOR AFFECTING IMMUNE RESPONSES (pages 531–538)

      Steven Specter, Roberta Schneider and Herman Friedman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47147.x

  9. Part IX. Lymphoregulatory Molecules from Macrophages

    1. Top of page
    2. Part I. Thymus Factors and Extractions in Hormonal Immunity: Isolation and Biochemical Characterization
    3. Part II. Thymus Factors Influencing inVitro andIn Vivo Biological Responses
    4. Part III. Clinical Trials with Thymus Factors
    5. Part IV. RNA and Transfer Factor in Immunity
    6. Part V. Role of Intracellular Factors in Immunity
    7. Part VI. Role of Afferent Lymphokines in Regulating Immuno-Logical Reactivity
    8. Part VII. Efferent Lymphokines Involved in Immunity
    9. Part VIII. Lymphoid Cell Factors Regulating Immunity
    10. Part IX. Lymphoregulatory Molecules from Macrophages
    1. MACROPHAGE SECRETION OF MICROMOLECULES (pages 550–556)

      Miguel J. Stadecker and Emil R. Unanue

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47149.x

    2. CONTROL OF B-CELL DIFFERENTIATION BY MACROPHAGES (pages 557–563)

      Michael K. Hoffmann

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47150.x

    3. MACROPHAGE FACTORS THAT ENHANCE THE ANTIBODY RESPONSE (pages 564–578)

      R. Christopher Butler, Alois Nowotny and Herman Friedman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47151.x

    4. DETECTION OF “DIALYZABLE TRANSFER FACTOR” IN VITRO: STRUCTURAL AND CHEMICAL CHARACTERIZATION OF THE ACTIVITY SPECIFIC FOR TUBERCULIN (pages 579–590)

      Gregory B. Wilson, H. Hugh Fudenberg and Gary V. Paddock

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47152.x

    5. COMPARISON OF ANTIGEN-SPECIFIC I-REGION-ASSOCIATED CELL INTERACTION FACTORS (pages 591–604)

      Marc Feldmann, Peter Erb, Sirkka Kontiainen, Ian Todd and James N. Woody

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1979.tb47153.x

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