Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

May 1980

Volume 344 Fourth Cooley's Anemia Symposium

Pages ix–ix, 1–446

    1. OPENING REMARKS (page ix)

      W. French Anderson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33643.x

  1. Part I. Gene Structure and Organization in Thalassemia

    1. Top of page
    2. Part I. Gene Structure and Organization in Thalassemia
    3. Part II. Globin Synthesis and Prenatal Diagnosis
    4. Part III. Regulation of Hemoglobin Synthesis
    5. Part IV. Pathophysiology of the Thalassemias
    6. Part V. Clinical Management of Thalassemia
    1. DETECTION OF GENE DEFECTS IN THE THALASSEMIAS AND RELATED DISORDERS (pages 1–11)

      Arthur Bank, J. Gregory Mears, Francesco Ramirez, A. Lee Burns, John Feldenzer and Sally Spence

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33644.x

    2. ANALYSIS OF β-GLOBIN GENES IN β^ THALASSEMIA (pages 12–30)

      Dorothy Tuan, P. Andrew Biro, J. K. De Riel and Bernard G. Forget

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33645.x

    3. MOLECULAR MECHANISMS IN α THALASSEMIA: RACIAL DIFFERENCES IN α-GLOBIN GENE ORGANIZATION (pages 31–40)

      Stephen H. Embury, Andree M. Dozy and Yuet Wai Kan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33646.x

    4. CHANGES IN GENE ORGANIZATION IN THE THALASSEMIAS (pages 41–47)

      J. Gregory Mears, Francesco Ramirez, John Feldenzer, A. Lee Burns and Arthur Bank

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33647.x

    5. SPECIFIC ABNORMALITIES OF GLOBIN GENE ORGANIZATION IN THE THALASSEMIA SYNDROMES (pages 48–61)

      Stuart H. Orkin

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33648.x

    6. α THALASSEMIA AND THE EXPRESSION OF HEMOGLOBIN G-PHILADELPHIA (pages 62–72)

      Saul Surrey, Kwaku Ohene-Frempong, Eric Rappaport, Jean Atwater and Elias Schwartz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33649.x

    7. THE STRUCTURE OF THE HUMAN γ-GLOBIN GENE LOCUS AND ITS RELATION TO THE δ/β-GLOBIN GENE LOCUS (pages 73–75)

      Robert Williamson, Peter Little and Richard Flavell

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33650.x

  2. Part II. Globin Synthesis and Prenatal Diagnosis

    1. Top of page
    2. Part I. Gene Structure and Organization in Thalassemia
    3. Part II. Globin Synthesis and Prenatal Diagnosis
    4. Part III. Regulation of Hemoglobin Synthesis
    5. Part IV. Pathophysiology of the Thalassemias
    6. Part V. Clinical Management of Thalassemia
    1. THE STRUCTURAL ANALYSIS OF THE HUMAN EPSILON-GLOBIN GENE AND ITS PRODUCT (pages 76–82)

      Francisco E. Baralle, Nicholas J. Proudfoot and John B. Clegg

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33651.x

    2. THE CLINICAL AND MOLECULAR HETEROGENEITY OF THE THALASSEMIA SYNDROMES (pages 83–100)

      D. J. Weatherall, J. B. Clegg, W. G. Wood, J. M. Old, D. R. Higgs, L. Pressley and P. D. Darbre

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33652.x

    3. HETEROGENEITY OF MESSENGER RNA DEFECTS IN THE THALASSEMIA SYNDROMES (pages 101–112)

      Edward J. Benz, Jonathan Glass, George A. Tsistrakis, Diane G. Hillman, Cesira Cavallesco, Elaine Coupal, Bernard G. Forget, Patricia A. Turner, Judith A. Kantor and Arthur W. Nienhuis

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33653.x

    4. NONSENSE MUTATION AS A CAUSE OF β THALASSEMIA (pages 113–119)

      Judy C. Chang, Yuet Wai Kan, Richard F. Trecartin and Gary F. Temple

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33654.x

    5. β-GLOBIN MESSENGER RNA IN FERRARA β THALASSEMIA (pages 120–131)

      F. Conconi, F. Bernardi, D. Buzzoni, I. Casoni, L. del Senno, G. Marchetti and C. M. Perrotta

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33655.x

    6. GLOBIN SYNTHESIS IN SEVERE AND INTERMEDIATE HOMOZYGOUS β THALASSEMIA IN ISRAEL (pages 132–140)

      Gabriel Cividalli, Helen Kerem and Eliezer A. Rachmilewitz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33656.x

    7. PRENATAL DIAGNOSIS OF HEMOGLOBINOPATHIES (pages 141–150)

      Yuet Wai Kan, Richard F. Trecartin and Andrée M. Dozy

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33657.x

    8. PRENATAL DIAGNOSIS OF HEMOGLOBINOPATHIES: THE NEW ENGLAND APPROACH (pages 151–164)

      Blanche P. Alter, Stuart H. Orkin, Bernard G. Forget and David G. Nathan

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33658.x

    9. PRENATAL DIAGNOSIS OF β THALASSEMIA: EXPERIENCE WITH 133 CASES AND THE EFFECT OF FETAL BLOOD SAMPLING ON CHILD DEVELOPMENT (pages 165–180)

      A. Cao, M. Furbetta, A. Angius, A. Ximenes, G. Angioni and F. Caminiti

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33659.x

    10. DISCUSSION PAPER PRENATAL DIAGNOSIS OF THALASSEMIA MAJOR IN GREECE: EVALUATION OF THE FIRST LARGE SERIES OF ATTEMPTS (pages 181–188)

      Vassiliki Aleporou-Marinou, Nausica Sakarelou-Papapetrou, Aris Antsaklis, Phaedon Fessas and Dimitris Loukopoulos

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33660.x

  3. Part III. Regulation of Hemoglobin Synthesis

    1. Top of page
    2. Part I. Gene Structure and Organization in Thalassemia
    3. Part II. Globin Synthesis and Prenatal Diagnosis
    4. Part III. Regulation of Hemoglobin Synthesis
    5. Part IV. Pathophysiology of the Thalassemias
    6. Part V. Clinical Management of Thalassemia
    1. OVERVIEW: MECHANISMS OF THE REGULATION OF HEMOGLOBIN SYNTHESIS AT THE CELLULAR LEVEL (pages 189–205)

      Arthur W. Nienhuis, Jane E. Barker and Richard D. Croissant

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33661.x

    2. CELLULAR REGULATION OF FETAL HEMOGLOBIN PRODUCTION (pages 206–218)

      Thalia Papayannopoulou and George Stamatoyannopoulos

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33662.x

    3. F-CELL REGULATION (pages 219–232)

      David G. Nathan and Blanche P. Alter

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33663.x

    4. EMBRYONIC HEMOGLOBIN SYNTHESIS IN HUMAN ERYTHROLEUKEMIA CELLS (pages 233–239)

      T. R. Rutherford, J. B. Clegg and D. J. Weatherall

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33664.x

    5. HEMOGLOBIN F IN β THALASSEMIA AND RELATED CONDITIONS (pages 240–252)

      W. A. Schroeder and T. H. J. Huisman

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33665.x

    6. THE RATIO OF Gγ AND Aγ CHAINS OF THE HEMOGLOBIN F SYNTHESIZED BY BFU-E-DERIVED COLONIES FROM BLOOD OF SUBJECTS WITH β+ THALASSEMIA AND RELATED HEMOGLOBINOPATHIES (pages 253–261)

      T. H. J. Huisman, G. D. Efremov, A. L. Reese, J. S. Howard, M. E. Gravely and J. B. Wilson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33666.x

    7. REGULATION OF GLOBIN GENE EXPRESSION AT THE MOLECULAR LEVEL (pages 262–279)

      W. French Anderson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33667.x

    8. EXPRESSION OF EMBRYONIC HEMOGLOBIN GENES IN α-THALASSEMIC AND IN ß-DUPLICATION MICE (pages 280–283)

      Raymond A. Popp, Loren C. Skow and J. Barry III Whitney

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33668.x

  4. Part IV. Pathophysiology of the Thalassemias

    1. Top of page
    2. Part I. Gene Structure and Organization in Thalassemia
    3. Part II. Globin Synthesis and Prenatal Diagnosis
    4. Part III. Regulation of Hemoglobin Synthesis
    5. Part IV. Pathophysiology of the Thalassemias
    6. Part V. Clinical Management of Thalassemia
    1. PATHOPHYSIOLOGY OF THALASSEMIA (pages 284–304)

      Edward C. Zaino

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33669.x

    2. IN VITRO GLOBIN CHAIN SYNTHESIS AFTER BLOOD TRANSFUSION IN SICILIAN HOMOZYGOUS β THALASSEMIA (pages 305–313)

      G. Russo, S. Musumeci, G. Schiliró, G. Pizzarelli, A. Fischer and M. A. Romeo

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33670.x

    3. SUSCEPTIBILITY OF THALASSEMIC RED BLOOD CELLS TO PHAGOCYTOSIS BY HUMAN MACROPHAGES IN VITRO (pages 314–322)

      Eliezer A. Rachmilewitz, Aliza Treves and Abraham J. Treves

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33671.x

    4. PROTEOLYSIS IN THALASSEMIA: STUDIES WITH PROTEASE INHIBITORS (pages 323–335)

      Dimitris Loukopoulos, Antigone Karoulias and Phaedon Fessas

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33672.x

    5. FISH AS MODELS FOR HEMOSIDEROSIS (pages 336–351)

      Paul J. Cheung, Ross F. Nigrelli, George D. Ruggieri, Kenneth Gold and John C. Baiardi

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33673.x

    6. THALASSEMIA IN THAILAND (pages 352–363)

      P. Wasi, S. Pootrakul, P. Pootrakul, P. Pravatmuang, P. Winichagoon and S. Fucharoen

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33674.x

    7. NEW CLINICAL AND BIOCHEMICAL FINDINGS FROM 235 PATIENTS WITH HEMOGLOBIN LEPORE (pages 364–374)

      N. Quattrin, L. Luzzatto and S. Quattrin Jr.

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33675.x

  5. Part V. Clinical Management of Thalassemia

    1. Top of page
    2. Part I. Gene Structure and Organization in Thalassemia
    3. Part II. Globin Synthesis and Prenatal Diagnosis
    4. Part III. Regulation of Hemoglobin Synthesis
    5. Part IV. Pathophysiology of the Thalassemias
    6. Part V. Clinical Management of Thalassemia
    1. CURRENT CONCEPTS IN THE OVERALL MANAGEMENT OF THALASSEMIA (pages 375–383)

      Richard D. Propper

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33676.x

    2. EVALUATION OF CARDIAC FUNCTION IN PATIENTS WITH THALASSEMIA MAJOR (pages 384–396)

      Arthur W. Nienhuis, Patricia Griffith, Hanna Strawczynski, Walter Henry, Jeffrey Borer, Martin Leon and W. French Anderson

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33677.x

    3. LONGITUDINAL STUDY OF CARDIAC FUNCTION IN THALASSEMIA MAJOR (pages 397–404)

      Kathryn H. Ehlers, Aaron R. Levin, Alicejane L. Markenson, Judith R. Marcus, Arthur A. Klein, Margaret W. Hilgartner and Mary Allen Engle

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33678.x

    4. DECREASING IRON STORES DURING INTENSIVE CHELATION THERAPY (pages 405–408)

      Alan Cohen and Elias Schwartz

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33679.x

    5. CHELATION THERAPY, TRANSFUSION REQUIREMENT, AND IRON BALANCE IN YOUNG THALASSEMIC PATIENTS (pages 409–417)

      Sergio Piomelli, Joseph Graziano, Margaret Karpatkin, Golde G. Dudell, David Hart, Margaret Hilgartner, Kusum Khanna, Lilliam M. Vaides-Cruz and Shobhana Vora

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33680.x

    6. GENERAL DISCUSSION:CLINICAL MANAGEMENT (pages 418–424)

      Sergio Piomelli

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33681.x

    7. THE STATUS OF NEW IRON CHELATORS* (pages 425–435)

      Anthony Cerami, Robert W. Grady, Charles M. Peterson and Kuldeep K. Bhargava

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33682.x

    8. THE CLINICAL SIGNIFICANCE OF MAGNESIUM DEPLETION IN THALASSEMIA (pages 436–443)

      Carol B. Hyman, Jorge A. Ortega, Gertrude Costin and Masato Takahashi

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33683.x

    9. CLOSING REMARKS (pages 444–446)

      Arthur Bank

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1980.tb33684.x

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