Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

June 1983

Volume 407 Cellular Systems for Toxicity Testing

Pages xi–xi, 1–484

    1. INTRODUCTION (page xi)

      Gary M. Williams

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47809.x

  1. Part I. Metabolism and End Points of I n Vitro Systems

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. NOTES ON XENOBIOTIC METABOLISM (pages 1–25)

      Silvio Garattini

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47810.x

    2. METABOLIC PROPERTIES OF IN VITRO SYSTEMS (pages 26–33)

      Anthony Dipple and C. Anita H. Bigger

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47811.x

    3. BIOLOGICAL SIGNIFICANCE OF END POINTS (pages 34–41)

      Virginia C. Dunkel

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47812.x

  2. Part II. Cytotoxicity

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. MECHANISMS OF TOXIC INJURY (pages 42–63)

      James W. Bridges, Diane J. Benford and Susan A. Hubbard

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47813.x

    2. SCREENING OF TOXIC COMPOUNDS IN MAMMALIAN CELL CULTURES (pages 64–77)

      Björn Ekwall

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47814.x

    3. ROLE OF CALCIUM IN CYTOTOXIC INJURY OF CULTURED HEPATOCYTES (pages 78–92)

      Daniel Acosta and Elsie M. B. Sorensen

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47815.x

  3. Part III. DNA Damage

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. ADAPTATION OF THE DNA-REPAIR AND MICRONUCLEUS TESTS TO HUMAN CELL SUSPENSIONS AND EXFOLIATED CELLS (pages 93–105)

      Hans F. Stich, Richard H. C. San and and Miriam P. Rosin

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47816.x

  4. Part IV. Chromosome Effects

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
  5. Part V. Mutagenicity Systems

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. THE ROLE OF NEUROSPORA IN EVALUATING ENVIRONMENTAL CHEMICALS FOR MUTAGENIC ACTIVITY (pages 177–185)

      Frederick J. de Serres and Henrich V. Malling

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47823.x

    2. MUTAGENICITY SCREENING WITH FUNGAL SYSTEMS (pages 186–196)

      Friedrich K. Zimmermann

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47824.x

  6. Part VI. Mammalian Mutagenesis

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. MUTATION SYSTEMS IN CULTURED MAMMALIAN CELLS (pages 221–230)

      Ernest H. Y. Chu

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47827.x

    2. THE L5178Y/TK GENE MUTATION ASSAY FOR THE DETECTION OF CHEMICAL MUTAGENS (pages 239–252)

      David E. Amacher and Gail N. Turner

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47829.x

    3. CELL-MEDIATED MUTAGENESIS OF CHINESE HAMSTER V79 CELLS AND SALMONELLA TYPHIMURIUM (pages 258–266)

      Robert Langenbach, Cathy Hix, Linda Oglcsby and James Allen

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47831.x

  7. Part VII. Transformation Systems

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. APPLICATION OF TRANSFORMATION SYSTEMS (pages 267–283)

      R. J. Pienta, J. A. Poiley and R. Raineri

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47832.x

    2. ROLE OF GENE AND CHROMOSOMAL MUTATIONS IN CELL TRANSFORMATION (pages 291–300)

      J. Carl Barrett, David G. Thomassen and Thomas W. Hesterberg

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47834.x

  8. Part VIII. Effects of Tumor Promoters

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. EFFECTS OF TUMOR PROMOTERS (pages 301–302)

      Walter Troll

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47835.x

    2. PHORBOL ESTER RECEPTORS AND THE IN VITRO EFFECTS OF TUMOR PROMOTERS (pages 303–315)

      Peter M. Blumberg, K. Barry Delclos, Joseph A. Dunn, Susan Jaken, Karen L. Leach and Emily Yeh

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47836.x

  9. Part IX. Mechanistic Significance and Relevance of Short-Term Tests

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. IDENTIFICATION OF GENOTOXINS: A CORRELATION OF BACTERIAL MUTATION WITH HEPATOCYTE DNA REPAIR (pages 334–350)

      G. S. Probst, C. Z. Thompson, L. E. Hill, J. K. Epp, S. B. Neal, T. J. Oberly and B. J. Bewsey

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47839.x

    2. RELEVANCY ISSUES (pages 362–366)

      V. A. Ray

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47841.x

  10. Part X. Application of Short-Term Tests to Chemical Safety Evaluation

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. LIMITED IN VIVO BIOASSAYS (pages 374–386)

      G. Mazue, D. Gouy, B. Remandet and J-M. Garbay

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47843.x

    2. IMPACT OF SHORT-TERM TESTS ON REGULATORY ACTION (pages 395–397)

      W. Gary Flamm and Virginia C. Dunkel

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47845.x

  11. Poster Papers

    1. Top of page
    2. Part I. Metabolism and End Points of I n Vitro Systems
    3. Part II. Cytotoxicity
    4. Part III. DNA Damage
    5. Part IV. Chromosome Effects
    6. Part V. Mutagenicity Systems
    7. Part VI. Mammalian Mutagenesis
    8. Part VII. Transformation Systems
    9. Part VIII. Effects of Tumor Promoters
    10. Part IX. Mechanistic Significance and Relevance of Short-Term Tests
    11. Part X. Application of Short-Term Tests to Chemical Safety Evaluation
    12. Poster Papers
    1. POSSIBILITY OF USING RAT MESOTHELIAL CELLS IN CULTURE TO TEST CYTOTOXICITY, CLASTOGENICITY, AND CARCINOGENICITY OF ASBESTOS FIBERS (pages 409–411)

      M. C. Jaurand, I. Bastie-Sigeac, M. J. Paterour, A. Renier and J. Bignon

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47847.x

    2. IN VITRO ALTERNATIVE IRRITANCY ASSAYS: COMPARISON OF CYTOTOXIC and MEMBRANE TRANSPORT EFFECTS OF ALCOHOLS (pages 416–419)

      E. Borenfreund, C. Shopsis, O. Borrero and S. Sathe

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47849.x

    3. CYTOGENETIC ANALYSIS OF SMALL-COLONY L5178Y TK-/- MUTANTS EARLY IN THEIR CLONAL HISTORY (pages 423–425)

      John Hozier, Jeffrey Sawyer, Donald Clive and Martha M. Moore

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47851.x

    4. AN IN VITRO HUMAN-ORGAN-SPECIFIC SYSTEM FOR TESTING GENOTOXIC AGENTS (pages 426–428)

      Steven M. D'Ambrosio, Carol T. Oravec and Ruth Gibson-D'Ambrosio

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47852.x

    5. SUPEROXIDE RESPONSE INDUCED BY INDOLE ALKALOID TUMOR PROMOTERS (pages 429–431)

      Jerry Formisano, Walter Troll and Takashi Sugimura

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47853.x

    6. DIFFERENTIAL IMMUNOMODULATORY EFFECTS OF ANTIBIOTICS ON CELLULAR IMMUNE REACTIVITY: AN INDICATOR OF POTENTIAL ANTIBIOTIC TOXICITY (pages 432–435)

      G. B. Wilson, J. F. Metcalf, E. Floyd, J. E. Smalls, C. J. Pickett and H. H. Fudenberg

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47854.x

    7. A MODEL FOR SELECTING SHORT-TERM TESTS OF CARCINOGENICITY (pages 436–437)

      Lester B. Lave, Gilbert S. Omenn, Kathleen D. Heffernan and Glen Dranoff

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47855.x

    8. A CRITICAL ANALYSIS OF THE AUTORADIOGRAPHIC DETECTION OF DNA REPAIR IN PRIMARY CULTURES OF RAT HEPATOCYTES (pages 444–447)

      M. Lonati-Galligani, P. H. M. Lohman and F. Berends

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47858.x

    9. DNA REPAIR IN PRIMARY HEPATOCYTES AND FIBROBLASTS AFTER HYDRALAZINE TREATMENT (pages 454–457)

      Dieter Müller and Emilio C. Puri

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47861.x

    10. NEUROTOXICITY TESTING: AN IN VITRO STRATEGY (pages 458–459)

      Roland M. Nardone

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47862.x

    11. INDUCTION OF DNA-STRAND BREAKS IN CULTURED HUMAN FIBROBLASTS BY REACTIVE METABOLITES (pages 460–462)

      Magnus Nordenskjöld and Peter Moldéus

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47863.x

    12. LUMINESCENCE METHODS FOR IDENTIFYING DNA-DAMAGING AGENTS (pages 467–468)

      Stanley Scher

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47865.x

    13. COMPARISON OF IN VITRO AND IN VIVO IMMUNOTOXICOLOGY ASSAYS (pages 469–471)

      Melinda J. Tarr, Richard G. Olsen and Debra L. Jacobs

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47866.x

    14. QUANTITATIVE, CLONAL STUDIES OF NEOPLASTIC PROGRESSION OF RAT TRACHEAL EPITHELIAL CELLS (pages 472–473)

      David G. Thomassen, Thomas E. Gray, S. Balakrishna Pai, Marc J. Mass, Paul Nettesheim and J. Carl Barrett

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47867.x

    15. THE GRANULOMA POUCH ASSAY (pages 476–478)

      P. Maier and G. Zbinden

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47869.x

    16. SITE SPECIFICITY IN THE INDUCTION OF NUCLEAR ANOMALIES BY CARCINOGENS (pages 479–482)

      Amiram Ronen, John A. Heddle and Alessandra M. V. Duncan

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47870.x

    17. Index of Contributors (pages 483–484)

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1983.tb47871.x

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