Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1984

Volume 436 Multiple Sclerosis: Experimental and Clinical Aspects

Pages xi–xii, 1–517

    1. Preface (pages xi–xii)

      LABE SCHEINBERG and CEDRIC S. RAINE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14770.x

    2. Opening Remarks (pages 1–4)

      SYLVIA LAWRY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14771.x

  1. Part I. Pathogenetic Mechanisms

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. Recent Advances in Myelin Biochemistry (pages 5–10)

      WILLIAM T. NORTON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14772.x

    2. Continual Breakdown and Regeneration of Myelin in Progressive Multiple Sclerosis Plaques (pages 11–32)

      J. W. PRINEAS, E. E. KWON, EUN-SOOK CHO and L. R. SHARER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14773.x

    3. The Current Status of Multiple Sclerosis Intra-Blood-Brain-Barrier IgG Synthesis (pages 52–67)

      WALLACE W. TOURTELLOTTE, MICHAEL J. WALSH, ROBERT W. BAUMHEFNER, SUSAN M. STAUGAITIS and PAUL SHAPSHAK

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14775.x

    4. Pathophysiology of Demyelination (pages 68–80)

      MICHAEL RASMINSKY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14776.x

    5. GENERAL DISCUSSION (pages 81–85)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14777.x

    6. Mechanisms and Consequences of Virus Persistence in the Human Nervous System (pages 86–96)

      V. ter MEULEN, M. J. CARTER, H. WEGE and R. WATANABE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14778.x

    7. Demyelination and Remyelination in Murine Viral Encephalomyelitis (pages 98–102)

      W. LANG, M. RODRIGUEZ, V. A. LENNON and P. W. LAMPERT

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14779.x

    8. Detection by Hybridization of Viral Infection of the Human Central Nervous System (pages 103–108)

      ASHLEY T. HAASE, LINDA STOWRING, PETER VENTURA, JACK BURKS, GEORGE EBERS, WALLACE TOURTELLOTTE and KENNETH WARREN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14780.x

    9. Multiple Sclerosis: Epidemiology and HLA Associations (pages 109–116)

      W. I. McDonald

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14781.x

    10. Family and Twin Studies in Multiple Sclerosis (pages 118–124)

      HENRY F. MCFARLAND, JEFFREY GREENSTEIN, DALE E. MCFARLIN, ROSWELL ELDRIDGE, XIAN-HAU XU and HELEN KREBS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14782.x

    11. Pathogenetic Mechanisms in Multiple Sclerosis: A Summary (pages 125–129)

      BYRON H. WAKSMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14783.x

    12. GENERAL DISCUSSION (pages 130–132)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14784.x

  2. Part II. Immunology of Multiple Sclerosis

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. IMMUNOLOGY OF MULTIPLE SCLEROSIS: Immunoregulation in Multiple Sclerosis (pages 133–139)

      BARRY G. W. ARNASON, JACK P. ANTEL and ANTHONY T. REDER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14785.x

    2. Characterization of Cerebrospinal Fluid Lymphocytes in Multiple Sclerosis (pages 151–162)

      JOHN R. RICHERT, JOHN W. ROSE, XIAN-HAU XU, JEFFREY I. GREENSTEIN, HENRY F. McFARLAND and DALE E. MCFARLIN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14787.x

    3. Further Lymphocyte Characterization in the Central Nervous System in Multiple Sclerosis (pages 163–178)

      UTE TRAUGOTT and CEDRIC S. RAINE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14788.x

    4. Cytotoxic Cells in Peripheral Blood and Cerebrospinal Fluid of Multiple Sclerosis Patients (pages 192–205)

      JEAN E. MERRILL, LAWRENCE W. MYERS and GEORGE W. ELLISON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14790.x

    5. Oligoclonal Banding in MS (pages 206–212)

      GEORGE C. EBERS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14791.x

    6. Antibodies to Glycosphingolipids in Patients with Multiple Sclerosis (pages 213–220)

      TAMAO ENDO, S. SCOTT STEWART, SAMAR K. KUNDU, SUSAN OSOVITZ and DONALD M. MARCUS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14792.x

    7. Immune Responses to Myelin Antigens in Multiple Sclerosis (pages 221–230)

      ROBERT P. LISAK, BURTON ZWEIMAN, AJMES B. BURNS, ABDOLMOHAMMAD ROSTAMI and DONALD H. SILBERBERG

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14793.x

  3. Part 11. Immunology of Multiple Sclerosis

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. GENERAL DISCUSSION (pages 231–232)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14794.x

  4. Part III. Clinical Manifestations of Multiple Sclerosis

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. T Regulator Cell Surface Antigens in Multiple Sclerosis (pages 247–253)

      ANTHONY T. REDER, JACK P. ANTEL and BARRY G. W. ARNASON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14796.x

    2. Evaluation of Leukocyte Surface Antigens in Patients with Multiple Sclerosis (pages 254–265)

      D. E. MCFARLIN and E. S. MINGIOLI

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14797.x

    3. Suppressor T Cells in MS: Do Changes in Numbers Vary with Clinical Activity? (pages 266–270)

      D. W. PATY and L. F. KASTRUKOFF

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14798.x

    4. The Failure of Monoclonal Antibody-defined Lymphocyte Subsets to Monitor Disease Activity in Patients with Multiple Sclerosis (pages 271–280)

      GEORGE P. A. RICE, JACK C. SIPE, SHERRY L. BRAHENY, ROBERT L. KNOBLER, DAVID A. FINNEY and MICHAEL B. A. OLDSTONE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14799.x

    5. T Cell Subsets in Patients with Multiple Sclerosis: An Overview (pages 281–290)

      HOWARD L. WEINER, DAVID A. HAFLER, ROBERT J. FALLIS, DAVID JOHNSON, KENNETH A. AULT and STEPHEN L. HAUSER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14800.x

    6. GENERAL DISCUSSION (pages 291–293)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14801.x

    7. Magnetic Resonance Imaging and CT Scanning in Multiple Sclerosis (pages 294–313)

      BURTON P. DRAYER and LYNN BARRETT

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14802.x

    8. Multiple Sclerosis Bladder: Studies and Care (pages 328–345)

      JERRY G. BLAIVAS, NANCY J. HOLLAND, BARBARA GIESSER, NICHOLAS LaROCCA, MICHELE MADONNA and LABE SCHEINBERG

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14804.x

  5. Part IV. Clinical Trials in Multiple Sclerosis

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. Disability Rating Scales in Multiple Sclerosis (pages 347–360)

      JOHN F. KURTZKE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14805.x

    2. Therapeutic Trials in Multiple Sclerosis: Azathioprine (pages 361–365)

      GEORGE W. ELLISON, LAWRENCE W. MYERS, M. RAY MICKEY, MARGARET V. FRANE, WALLACE W. TOURTELLOTTE, CELSA A. SPINA and JOHN L. FAHEY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14806.x

    3. Clinical Trials of Copolymer I in Multiple Sclerosis (pages 366–372)

      M. B. BORNSTEIN, A. I. MILLER, S. SLAGLE, R. ARNON, M. SELA and D. TEITELBAUM

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14807.x

    4. The Use of Cyclophosphamide in the Treatment of Multiple Sclerosis (pages 373–381)

      HOWARD L. WEINER, STEPHEN L. HAUSER, DAVID A. HAFLER, ROBERT J. FALLIS, JAMES R. LEHRICH and DAVID M. DAWSON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14808.x

    5. Clinical Trial of Natural Alpha Interferon in Multiple Sclerosis (pages 382–388)

      ROBERT L. KNOBLER, HILLEL S. PANITCH, SHERRY L. BRAHENY, JACK C. SIPE, GEORGE P. A. RICE, JOHN R. HUDDLESTONE, GORDON S. FRANCIS, CAROL J. HOOPER, ROBERTA M. KAMIN-LEWIS, KENNETH P. JOHNSON, MICHAEL B. A. OLDSTONE and THOMAS C. MERIGAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14809.x

    6. Plasmapheresis and Combined Immunosuppressive Drug Therapy in Chronic Progressive Multiple Sclerosis: Choosing the Patient Who Should Respond (pages 389–396)

      BHUPENDRA O. KHATRI, MICHAEL P. McQUILLEN and SUSAN KOETHE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14810.x

    7. Total Lymphoid Irradiation in Chronic Progressive Multiple Sclerosis: A Preliminary Report (pages 397–409)

      M. P. HAFSTEIN, C. DEVEREUX, R. TROIANO, G. ZITO, R. VIDAVER, P. C. DOWLING, M. LAVENHAR and S. D. COOK

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14811.x

    8. Intrathecal IgG Synthesis and IgG Index after Intensive and Chronic Immunosuppressive Treatment of Multiple Sclerosis (pages 410–417)

      O. R. HOMMES, K. J. B. LAMERS and W. van GEEL

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14812.x

    9. Clinical Trials in Multiple Sclerosis: Problems and Opportunities (pages 418–422)

      DONALD H. SILBERBERG

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14813.x

    10. GENERAL DISCUSSION (pages 423–424)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14814.x

  6. Part V. Psychosocial and Economic Features in MS

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. The Current Management of Multiple Sclerosis (pages 425–434)

      RANDALL T. SCHAPIRO, STANLEY vanden NOORT and LABE SCHEINBERG

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14815.x

    2. Psychosocial Factors in Multiple Sclerosis and the Role of Stress (pages 435–442)

      NICHOLAS G. LaROCCA

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14816.x

    3. Sexual Dysfunctions in Multiple Sclerosis (pages 443–452)

      GEORGE SZASZ, D. PATY and W. L. MAURICE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14817.x

    4. Development and Testing of a Minimal Record of Disability in Multiple Sclerosis (pages 453–468)

      ROBERT J. SLATER, NICHOLAS G. LaROCCA and LABE C. SCHEINBERG

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14818.x

    5. The National Multiple Sclerosis Survey: Background and Economic Impact (pages 469–470)

      FREDERIC D. WEINFELD and HERBERT M. BAUM

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14819.x

    6. GENERAL DISCUSSION (page 471)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14820.x

    7. The Future of Funding for MS Research (pages 472–474)

      THOR HANSON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14821.x

  7. Poster Papers

    1. Top of page
    2. Part I. Pathogenetic Mechanisms
    3. Part II. Immunology of Multiple Sclerosis
    4. Part 11. Immunology of Multiple Sclerosis
    5. Part III. Clinical Manifestations of Multiple Sclerosis
    6. Part IV. Clinical Trials in Multiple Sclerosis
    7. Part V. Psychosocial and Economic Features in MS
    8. Poster Papers
    1. Multiple Sclerosis and Epstein-Barr Virus: Guilt by Association? (page 475)

      HELEN B. WARNER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14822.x

    2. Fcγ Receptors in Multiple Sclerosis Brains (pages 476–479)

      HARALD NYLAND, SVERRE MØRK and ROALD MATRE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14823.x

    3. Long-Term Culture of Bulk Isolated Adult Human Oligodendrocytes (pages 480–482)

      SEUNG U. KIM, GIUSEPPE MORETTO, DOO H. SHIN and DONALD W. PATY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14824.x

    4. Early Experience in Nuclear Magnetic Resonance Imaging of Multiple Sclerosis (pages 483–486)

      D. LI, J. MAYO, S. FACHE, W. D. ROBERTSON, D. PATY and M. GENTON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14825.x

    5. Electrophysiological Confirmation of Orientation-specific Contrast Losses in Multiple Sclerosis (pages 487–491)

      MARK J. KUPERSMITH, JEREMIAH I. NELSON, WILLIAM H. SEIPLE and RONALD E. CARR

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14826.x

    6. A Monoclonal Antibody for Astrocytes (pages 492–494)

      S. K. MALHOTRA, F. WONG, N. SINHA, V. MANICKEVAL, T. K. SHNITKA and K. G. WARREN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14827.x

    7. Neuropsychological Studies in Chronic Progressive Multiple Sclerosis (pages 495–497)

      STEPHEN M. RAO, THOMAS A. HAMMEKE, SANDER GLATT, MICHAEL P. McQUILLEN, B. O. KHATRI, ANNE MARIE RHODES and SUSAN POLLARD

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14828.x

    8. Copolymer I: Effect on Normal Human Lymphocytes (pages 498–499)

      C. F. BROSNAN, M. LITWAK, P. A. NEIGHBOUR and M. B. BORNSTEIN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14829.x

    9. Metabolic Pathology of Brain Inflammation (pages 500–503)

      RICHARD J. DiROCCO

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14830.x

    10. A Murine Model of Herpes Simplex Virus Type 1 of the Nervous System (pages 504–505)

      LORNE F. KASTRUKOFF, ALLEN S. LAU and DONALD W. PATY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14831.x

    11. Reduced OKT8+ and OKT3+ Cells in Blood of Progressive MS Patients (pages 506–507)

      J. OGER, S. JACKEVICIUS, J. P. ANTEL and B. G. ARNASON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14832.x

    12. CSF Antibrain Antibodies in Neurologic Diseases (pages 508–510)

      A. A. VANDENBARK, F. VAN ROMPAEY, D. NIJST, H. OFFNER, H. HEYLIGEN and J. RAUS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14833.x

    13. Characterization Of Antigen-specific T Cells in Multiple Sclerosis Twins with Elevated Responses to Measles Virus (pages 511–512)

      J. I. GREENSTEIN, S. JACOBSON, J. R. RICHERT and H. F. McFARLAND

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14834.x

    14. The National Neurological Research Bank: A Collection of Cryopreserved Human Neurological Specimens for Neuroscientists (pages 513–516)

      W. W. TOURTELLOTTE, H. H. ITABASHI, I. ROSARIO and K. BERMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14835.x

    15. Index of Contributors (page 517)

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1984.tb14836.x

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