Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

June 1985

Volume 445 Fifth Cooleyís Anemia Symposium

Pages 1–468

  1. Part I. Gene Deeects in the Thalassemias

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Abnormal Globin Gene Structure and Expression in β-Thalassemia (pages 1–9)

      ARTHUR BANK, CARL DOBKIN, MARYANN DONOVAN-PELUSO and KATHERINE YOUNG

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17169.x

    2. Deletion Analysis of the Human γ-Globin IVS2: Sequence Requirements for RNA Splicing (pages 10–19)

      RICHARD A. SPRITZ and VICKY L. VAN SANTEN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17170.x

    3. A Novel Deletion in the β-Globin Gene Complex (pages 20–27)

      J. S. WAINSCOAT, S. L. THEIN, W. G. WOOD, D. J. WEATHERALL, A. METAXOTOU-MAVROMATI, S. TZOTOS, E. KANAVAKIS and C. KATTAMIS

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17171.x

    4. Molecular Pathology of α-Thalassemia (pages 28–36)

      YUET WAI KAN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17172.x

    5. Molecular Rearrangements of the Human α-Globin Gene Cluster (pages 45–56)

      D. R. HIGGS, A. V. S. HILL, R. NICHOLLS, S. E. Y. GOODBOURN, H. AYYUB, H. TEAL, J. B. CLEGG and D. J. WEATHERALL

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17174.x

  2. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Metabolism of Structurally Abnormal mRNAs Resulting from β-Thalassemia Mutations (pages 57–67)

      EDWARD J. BENZ JR., KENICHI TAKESHITA and ALPHONSE L. SCARPA

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17175.x

    2. Genetic and Molecular Analysis of Mild Forms of Homozygous β-Thalassemia (pages 68–80)

      D. J. WEATHERALL, J. S. WAINSCOAT, S. L. THEIN, J. M. OLD, W. G. WOOD, D. R. HIGGS and J. B. CLEGG

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17176.x

    3. Alterations in Membrane Protein and Phosphorylation Pattern in β-Thalassemic Red Blood Cells (pages 81–91)

      JORGE ERUSALIMSKY, EILAT SHINAR, ELIEZER A. RACHMILEWITZ and YORAM MILNER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17177.x

    4. Thalassemia in China (pages 92–105)

      TIAN-YING YANG, XUE-YONG YANG, WEN-CHIEH CH'EN, SHU-LING QI, YONG-JUAN JIN, WU-JUN GAN and QUAN QU

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17178.x

  3. Part I. Gene Deeects in the Thalassemias

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Multiple Molecular Bases for Thalassemia Intermedia in East Sicily (pages 106–110)

      C. TROUNGOS, R. KRISHNAMOORTHY, J. ELION, T. LOMBARDO, G. SORTINO, E. CACCIOLA and D. LABIE

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17179.x

  4. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. The Silent Carrier of β-Thalassemia (pages 111–118)

      G. V. SCIARRATTA, M. I. PARODI, S. F. AGOSTI VALLERINO and G. SANSONE

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17180.x

    2. Thalassemia in Southeast Asia: Determination of Different Degrees of Severity of Anemia in Thalassemia (pages 119–126)

      PRAWASE WASI, PENSRI POOTRAKUL, SUTHAT FUCHAROEN, PRANEE WINICHAGOON, PRAPON WILAIRAT and AMORNRAT PROMBOON

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17181.x

    3. Defective Vitamin D Metabolism in Thalassemia Major (pages 127–134)

      E. C. ZAINO, J. K. YEH and J. ALOIA

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17182.x

    4. Observations on Oxygen Delivery, Methemoglobinemia, and Arterial Oxygenation in Patients with β-Thalassemia (pages 135–147)

      TH. TASSIOPOULOS, PH. FESSAS, J. ROMBOS and D. LOUKOPOULOS

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17183.x

    5. Clinical and Molecular Heterogeneity of δ, β-Thalassemia in Sicily (pages 148–158)

      GINO SCHILIRÓ, SALVATORE MUSUMECI, MARIA ANTONIETTA ROMEO, FELICIA DI GREGORIO, ALFONSINA D'AGATA, ROSARIO TESTA and GIUSEPPE RUSSO

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17184.x

  5. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Molecular Analysis of Deletion and Nondeletion Hereditary Persistence of Fetal Hemoglobin and Identification of a New Mutation Causing β-Thalassemia (pages 159–169)

      ELISE A. FEINGOLD, FRANCIS S. COLLINS, JAMES E. METHERALL, CHRISTIAN J. STOECKERT JR., SHERMAN M. WEISSMAN and BERNARD G. FORGET

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17185.x

    2. Heterogeneity of δ, β-Thalassemia and Hereditary Persistence of Hb F in the Mediterranean Area (pages 170–176)

      S. OTTOLENGHI, B. GIGLIONI, P. COMI, S. GUIDA, C. CASINI, S. MERLI, R. MANTOVANI, F. TERRAGNI, D. AGHIB, G. SAGLIO, C. CAMASCHELLA and U. MAZZA

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17186.x

    3. Hb F Production in Stressed Erythropoiesis: Observations and Kinetic Modelsa (pages 188–197)

      G. STAMATOYANNOPOULOS, R. VEITH, R. GALANELLO and TH. PAPAYANNOPOULOU

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17188.x

    4. Pharmacological Manipulation of Fetal Hemoglobin Synthesis in Patients with Severe β-Thalassemia (pages 198–211)

      ARTHUR W. NIENHUIS, TIMOTHY J. LEY, R. KEITH HUMPHRIES, NEAL S. YOUNG and GEORGE DOVER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17189.x

    5. Analysis of Globin Gene Inversion Reveals Similarities with Immunoglobulin Rearrangement (pages 212–217)

      M. W. JENNINGS, W. G. WOOD, R. W. JONES and D. J. WEATHERALL

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17190.x

    6. Progress toward Increasing Fetal Hemoglobin Production in Man: Experience with 5-Azacytidine and Hydroxyurea (pages 218–224)

      GEORGE J. DOVER, SAMUEL CHARACHE, RICHARD NORA and SAMUEL H. BOYER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17191.x

    7. A Model for Hemoglobin F Synthesis in Adult Life: Evidence for Regulation at the Level of Erythroblasts (pages 225–234)

      C. PESCHLE, A. R. MIGLIACCIO, G. MIGLIACCIO, F. MAVILIO, E. ROCCA, M. PETRINI, G. MASTROBERARDINO, P. COMI, B. GIGLIONI and S. OTTOLENGHI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17192.x

    8. The Ratio of the Gγ and Aγ Chains: Variations due to Anomalies at the Molecular Level (pages 235–247)

      J. G. GILMAN, T. HARANO, T. NAKATSUJI, I. BAKIOGLU, A. L. REESE, M. B. GARDINER and T. H. J. HUISMAN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17193.x

  6. Part IV. Therapy of Thalessemia

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Current Therapy and New Approaches to the Treatment of Thalassemia Major (pages 248–255)

      LAWRENCE WOLFE, DARLENE SALLAN and DAVID G. NATHAN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17194.x

    2. Current Strategies in the Management of Cooley's Anemia (pages 256–267)

      S. PIOMELLI, D. HART, J. GRAZIANO, G. GRANT, M. KARPATKIN and K. McCARTHY

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17195.x

    3. Treatment of Iron Overload in Cooley's Anemia (pages 274–281)

      A. COHEN, J. MIZANIN and E. SCHWARTZ

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17197.x

    4. The Effect of Subcutaneous Deferoxamine on the Cardiac Profile of Thalassemia Major: A Five-Year Study (pages 282–292)

      PATRICIA J. V. GIARDINA, KATHRYN H. EHLERS, MARY ALLEN ENGLE, ROBERT W. GRADY and MARGARET W. HILGARTNER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17198.x

    5. Combined Subcutaneous and High-Dose Intravenous Deferoxamine Therapy of Thalassemia (pages 293–303)

      CAROL B. HYMAN, CATHY L. AGNESS, ROSA RODRIGUEZ-FUNES and MIRKA ZEDNIKOVA

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17199.x

    6. Improved Oxygen Delivery to Tissues and Iron Chelator Transport through the Use of Lysed and Resealed Red Blood Cells: A New Perspective on Cooley's Anemia Therapy (pages 304–315)

      C. ROPARS, B. TEISSEIRE, G. AVENARD, M. CHASSAIGNE, C. HUREL, R. GIROT and C. NICOLAU

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17200.x

    7. A Psychosocial Needs Assessment of Patients with Homozygous β-Thalassemia (pages 316–323)

      RICKY WOO, PATRICIA J. V. GIARDINA and MARGARET W. HILGARTNER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17201.x

    8. Psychosocial Impacts on a Thalassemic Patient's Life (pages 324–326)

      VIVIAN GIORDANO

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17202.x

    9. Thalassemic Children's Understanding of Illness: A Study of Cognitive and Emotional Factors (pages 327–336)

      MIRIAM SHERMAN, DIANE KOCH, PATRICIA GIARDINA, PAUL HYMOWITZ, RICHARD SIEGEL and THEODORE SHAPIRO

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17203.x

  7. Part V. Antenatal Diagnosis

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Prenatal Diagnosis of Hemoglobinopathies by DNA Analysis (pages 337–348)

      HAIG H. KAZAZIAN JR., CORINNE D. BOEHM and CAROL E. DOWLING

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17204.x

    2. First Trimester Diagnosis of the Hemoglobin Disorders (pages 349–356)

      J. M. OLD, D. J. WEATHERALL, R. H. T. WARD, M. PETROU, B. MODELL, C. H. RODECK, R. WARREN and J. M. MORSMAN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17205.x

    3. Prenatal Diagnosis of Thalassemia and Hb S Syndromes in Greece: An Evaluation of 1500 Cases (pages 357–375)

      DIMITRIS LOUKOPOULOS, PHOTINI KARABABA, ARIS ANTSAKLIS, JOHN PANOURGIAS, MARINA BOUSSIOU, KOSTAS KARAYANNOPOULOS, JOHN POLITIS, DAPHNE ROMBOU, ANASTASIA KALTSOYA-TASSIOPOULOU and PHAEDON FESSAS

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17206.x

    4. Antenatal Diagnosis of Thalassemia Major in Sardinia (pages 380–392)

      A. CAO, P. COSSU, A. M. FALCHI, G. MONNI, M. PIRASTU, C. ROSATELLI, M. T. SCALAS and T. TUVERI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17208.x

    5. Antenatal Diagnosis of Thalassemia: A Review (pages 393–407)

      BLANCHE P. ALTER and For the World Health Organization International Registry for Prenatal Monitoring of Hereditary Anemias

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17209.x

  8. Part VI. Future Directions in Thalassemia Research

    1. Top of page
    2. Part I. Gene Deeects in the Thalassemias
    3. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    4. Part I. Gene Deeects in the Thalassemias
    5. Part II. Pathophysiology of Thalassemia: Clinical and Molecular Aspects
    6. Part III. Molecular Basis of Hereditary Persistence of Fetal Hemoglobin and δ, β-Thalassemia
    7. Part IV. Therapy of Thalessemia
    8. Part V. Antenatal Diagnosis
    9. Part VI. Future Directions in Thalassemia Research
    1. Marrow Transplantation for Thalassemia (pages 417–427)

      E. D. THOMAS, J. E. SANDERS, C. D. BUCKNER, TH. PAPAYANNOPOULOU, C. BORGNA-PIGNATTI, P. DE STEFANO, K. M. SULLIVAN, H. J. DEEG, R. P. WITHERSPOON, F. R. APPELBAUM, R. A. CLIFT and R. STORB

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17211.x

    2. Marrow Transplantation for Thalassemia after Treatment with Busulfan and Cyclophosphamide (pages 428–431)

      G. LUCARELLI, P. POLCHI, T. IZZI, M. MANNA, C. DELFINI, M. GALIMBERTI, A. PORCELLINI, L. MORETTI, A. MANNA and G. SPARAVENTI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17212.x

    3. Hematology of a Murine β-Thalassemia: A Longitudinal Study (pages 432–444)

      R. A. POPP, D. M. POPP, F. M. JOHNSON, L. C. SKOW and S. E. LEWIS

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17213.x

    4. Attempts at Gene Therapy in β-Thalassemic Mice (pages 445–451)

      W. FRENCH ANDERSON, SHELDON GOLDBERG, PHILIP KANTOFF, PATRICIA BERG, MARTIN EGLITIS and R. KEITH HUMPHRIES

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17214.x

    5. Concluding Remarks (pages 452–454)

      ARTHUR BANK

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17215.x

    6. New Research Approaches to Cooley's Anemia Therapy (pages 455–468)

      DAVID G. BADMAN, ALAN S. LEVINE and W. FRENCH ANDERSON

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb17216.x

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