Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

October 1985

Volume 451 Adenosine Deaminase in Disorders of Purine Metabolism and in Immune Deficiency

Pages 1–339

  1. Part I. Relation of Purine Metabolism to Immune Deficiency

    1. Top of page
    2. Part I. Relation of Purine Metabolism to Immune Deficiency
    3. Part II. Clinical Observations
    4. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA
    5. Part IV. BIOLOGICAL STUDIES
    6. Part V. Control of Purine Metabolism in Phagocytosis
    7. Poster Papers
    1. Preface (page xi)

      GEORGE L. TRITSCH

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27089.x

    2. ADA and PNP Deficiencies: How It All Began (pages 1–8)

      ELOISE R. GIBLETT

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27090.x

    3. Overview of Possible Relation of Defects in Purine Metabolism to Immune Deficiency (pages 9–19)

      J. EDWIN SEEGMILLER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27091.x

    4. Roles of Alternative Synthetic and Catabolic Purine Pathways in T Lymphocyte Differentiation (pages 26–33)

      AMOS COHEN, JERZY BARANKIEWICZ and ERWIN W. GELFAND

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27093.x

    5. Metabolic Basis for Immune Dysfunction in Adenosine Deaminase Deficiency (pages 34–41)

      DENNIS A. CARSON, TAIZO IIZASA, SHIRO SETO, CARLOS J. CARRERA, MASARU KUBOTA, ERIK H. WILLIS, DONALD B. WASSON and OLAVI KAJANDER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27094.x

    6. Human Placental Nucleoside Kinase Activities (pages 42–53)

      MARY C. HURLEY and IRVING H. FOX

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27095.x

    7. Adenosine Deaminase and Immune Dysfunction Biochemical Correlates Defined by Molecular Analysis throughout a Disease Course (pages 54–65)

      MARY SUE COLEMAN, MARY JO DANTON and ANNE PHILIPS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27096.x

    8. Urinary Purines and Nucleosides in Immune Deficiencies (pages 66–77)

      GORDON C. MILLS, FRANK C. SCHMALSTIEG and RANDALL M. GOLDBLUM

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27097.x

    9. Abnormalities in S-Adenosylhomocysteine Hydrolysis, ATP Catabolism, and Lymphoid Differentiation in Adenosine Deaminase Deficiency (pages 78–86)

      MICHAEL S. HERSHFIELD, JOANNE KURTZBERG, V. NAMBI AIYAR, EALL JOO SUH and RICHARD SCHIFF

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27098.x

    10. Metabolic Investigations of Horses with Severe Combined Immunodeficiency (pages 87–97)

      NANCY S. MAGNUSON and LANCE E. PERRYMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27099.x

    11. Adenosine Deaminase Impairment and Ribonucleotide Reductase in Human Cells (pages 98–112)

      HOWARD L. ELFORD and ALAN L. LIN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27100.x

  2. Part II. Clinical Observations

    1. Top of page
    2. Part I. Relation of Purine Metabolism to Immune Deficiency
    3. Part II. Clinical Observations
    4. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA
    5. Part IV. BIOLOGICAL STUDIES
    6. Part V. Control of Purine Metabolism in Phagocytosis
    7. Poster Papers
    1. Relevance of Adenosine Deaminase to Organ Transplantation (pages 113–122)

      CALIANN T. LUM, DAVID E. R. SUTHERLAND, NINA HSIAO and JOHN S. NAJARIAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27101.x

    2. Deoxycoformycin in the Treatment of Leukemias and Lymphomas (pages 123–128)

      JOHN F. SMYTH, H. GRANT PRENTICE, STEPHEN PROCTOR and A. VICTOR HOFFBRAND

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27102.x

    3. Biochemical Consequences of Adenosine Deaminase Inhibition in Vivo : Differential Effects in Acute and Chronic T Cell Leukemia (pages 129–137)

      BEVERLY S. MITCHELL, YECHEZKEL SIDI, MICHAEL HERSHFIELD and CHARLES A. KOLLER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27103.x

    4. The Activity of Deoxycoformycin (Pentostatin) in Refractory Leukemias and Lymphomas (pages 138–141)

      ALEXANDER S. D. SPIERS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27104.x

  3. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA

    1. Top of page
    2. Part I. Relation of Purine Metabolism to Immune Deficiency
    3. Part II. Clinical Observations
    4. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA
    5. Part IV. BIOLOGICAL STUDIES
    6. Part V. Control of Purine Metabolism in Phagocytosis
    7. Poster Papers
    1. Adenosine Deaminase and Malignant Cells (pages 142–149)

      M. EARL BALIS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27105.x

    2. Purine Metabolism in Leukemia (pages 160–168)

      RAM P. AGARWAL, RICHARD BELL, ANNE LILLQUIST and RONALD McCAFFREY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27107.x

    3. Association of Adenosine Deaminase with Differentiation of Normal and Leukemic T and B Lymphocytes (pages 169–179)

      B. E. CHECHIK, W. P. SCHRADER, B. FERNANDES, S. SENGUPTA and E. W. GELFAND

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27108.x

    4. Inhibition of Interleukin-2 Messenger RNA in Mouse Lymphocytes by 2′-Deoxycoformycin and Adenosine Metabolites (pages 180–187)

      MARVIN B. COHEN and ROBERT I. GLAZER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27109.x

  4. Part IV. BIOLOGICAL STUDIES

    1. Top of page
    2. Part I. Relation of Purine Metabolism to Immune Deficiency
    3. Part II. Clinical Observations
    4. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA
    5. Part IV. BIOLOGICAL STUDIES
    6. Part V. Control of Purine Metabolism in Phagocytosis
    7. Poster Papers
    1. Role of Nucleoside Transport in Drug Action The Adenosine Deaminase Inhibitor, Deoxycoformycin, and the Antiplatelet Drugs, Dipyridamole and Dilazep (pages 188–203)

      ROBERT E. PARKS JR., DOLORETTA D. DAWICKI, KAILASH C. AGARWAL, SHIH-FONG CHEN and JOHANNA D. STOECKLER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27110.x

    2. Inhibitors of Adenosine Deaminase and the Development of Antiviral Agents (pages 204–214)

      SEYMOUR S. COHEN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27111.x

    3. Effects of Adenosine Deaminase Inhibitors on Lymphocyte-mediated Cytolysis (pages 215–226)

      GERALD WOLBERG and THOMAS P. ZIMMERMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27112.x

    4. Molecular Biology of the Adenosine Deaminase Gene and Messenger RNA (pages 227–237)

      JOHN J. HUTTON and DAN A. WIGINTON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27113.x

    5. cDNA and Amino Acid Sequence of Human Adenosine Deaminase (pages 238–244)

      PETER E. DADDONA, STUART H. ORKIN, DONNA S. SHEWACH and WILLIAM N. KELLEY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27114.x

    6. Mammalian Expression of Cloned cDNA Sequences Encoding Human Purine Nucleoside Phosphorylase and Adenosine Deaminase (pages 245–249)

      R. SCOTT McIVOR, DINKO VALERIO, STEVEN R. WILLIAMS, JUDY M. GODDARD, CHRISTIAN C. SIMONSEN, MARJA G. C. DUYVESTEYN, HANS VAN ORMONDT, ALEX J. VAN DER EB and DAVID W. MARTIN JR.

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27115.x

  5. Part V. Control of Purine Metabolism in Phagocytosis

    1. Top of page
    2. Part I. Relation of Purine Metabolism to Immune Deficiency
    3. Part II. Clinical Observations
    4. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA
    5. Part IV. BIOLOGICAL STUDIES
    6. Part V. Control of Purine Metabolism in Phagocytosis
    7. Poster Papers
    1. Ectoenzyme Action on Purine Nucleotides in Macrophages and Subsequent Reactions (pages 250–255)

      MANFRED L. KARNOVSKY and MARIE-MARTHE PHILIPPEAUX

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27116.x

    2. Regulation of Mononuclear Leukocyte Function by Transmethylation Reactions (pages 256–263)

      MARILYN C. PIKE and RALPH SNYDERMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27117.x

    3. Role of Adenosine Deaminase in Human Monocyte Differentiation and Tumor Cell Cytotoxicity (pages 264–278)

      ALAN M. KAPLAN, THERESA L. GERRARD, JOAN STRAWSON, COLES SQUIRE and MARSA AULTMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27118.x

    4. Purine Catabolism as a Source of Superoxide in Macrophages (pages 279–290)

      GEORGE L. TRITSCH and PAUL W. NISWANDER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27119.x

    5. Adenosine Modulates the Generation of Superoxide Anion by Stimulated Human Neutrophils via Interaction with a Specific Cell Surface Receptor (pages 291–301)

      BRUCE N. CRONSTEIN, SARA B. KRAMER, ELLIOT D. ROSENSTEIN, GERALD WEISSMANN and ROCHELLE HIRSCHHORN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27120.x

  6. Poster Papers

    1. Top of page
    2. Part I. Relation of Purine Metabolism to Immune Deficiency
    3. Part II. Clinical Observations
    4. Part III. ADA ACTIVITY AS RELATED TO NEOPLASIA
    5. Part IV. BIOLOGICAL STUDIES
    6. Part V. Control of Purine Metabolism in Phagocytosis
    7. Poster Papers
    1. Impairment of dATP but Not ATP Catabolism in Adenosine Deaminase Deficiency (pages 302–304)

      JERZY BARANKIEWICZ and AMOS COHEN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27121.x

    2. Thymocyte Differentiation and ADA Inhibition (pages 305–307)

      RANDALL W. BARTON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27122.x

    3. ADA Activity Levels in IL-2-dependent Cultured Murine Cytotoxic T Lymphocytes (pages 308–310)

      M. CASTELLAZZI, M. MINKOWSKI, P. VIELH and G. BUTTIN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27123.x

    4. Three-Dimensional Structure of Human Erythrocytic Purine Nucleoside Phosphorylase (pages 311–312)

      S. E. EALICK, T. J. GREENHOUGH, Y. S. BABU, D. C. CARTER, W. J. COOK, C. E. BUGG, S. A. RULE, J. HABASH, J. R. HELLIWELL, J. D. STOECKLER, S. F. CHEN and R. E. PARKS JR.

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27124.x

    5. Effects of 8-Aminoguanosine, an Inhibitor of Purine Nucleoside Phosphorylase, on Plasma Nucleosides in Wistar Rats (pages 313–314)

      RICHARD B. GILBERTSEN and MI K. DONG

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27125.x

    6. Levels of dATP in ADA-inhibited Human Peripheral Blood B and T Lymphocytes Cultured in Deoxyadenosine (pages 315–318)

      H. GRUBER, A. COHEN, D. REDELMAN and H. BLUESTEIN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27126.x

    7. The Treatment of Hairy-Cell Leukemia with 2′-Deoxycoformycin (pages 319–320)

      JAMES B. JOHNSTON, LYONEL G. ISRAELS and ROBERT I. GLAZER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27127.x

    8. Adenosine Deaminase Complexing Protein in Transformed Cells and Colon Cancer (pages 324–327)

      JOOP TEN KATE, JUUL T. WIJNEN, FRED T. BOSMAN and P. MEERA KHAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27129.x

    9. Arabinosylguanine Toxicity in Syngeneic Cultured Human T and B Lymphoblasts (pages 328–331)

      BUDDY ULLMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27130.x

    10. The Human Gene for Adenosine Deaminase : Its Structural Organization and Expression in Mouse Cells (pages 332–335)

      D. VALERIO, Th. M. BERKVENS, M. G. C. DUYVESTEYN, L. VAN DER VOORN, B. M. M. DEKKER, H. VAN ORMONDT, P. MEERA KHAN and A. J. VAN DER EB

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27131.x

    11. Rapid Identification of Functional Murine Adenosine Deaminase cDNA Clones by Genetic Complementation in Bacteria (pages 336–339)

      CHO-YAU YEUNG, DIANE E. INGOLIA and RODNEY E. KELLEMS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1985.tb27132.x

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