Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1986

Volume 479 Tetrodotoxin, Saxitoxin, and the Molecular Biology of the Sodium Channel

Pages ix–x, 1–445

  1. Preface

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. Preface (pages ix–x)

      C. Y. KAO and S. R. LEVINSON

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15555.x

  2. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. Chemistry and Biology of Saxitoxin and Related Toxins (pages 15–23)

      EDWARD J. SCHANTZ

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15557.x

    2. The Chemistry of Tetrodotoxin (pages 32–43)

      HARRY S. MOSHER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15559.x

    3. Interspecies Distribution and Possible Origin of Tetrodotoxin (pages 44–51)

      T. YASUMOTO, H. NAGAI, D. YASUMURA, T. MICHISHITA, A. ENDO, M. YOTSU and Y. KOTAKI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15560.x

  3. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. Kinetics of TTX-STX Block of Sodium Channels (pages 68–83)

      W. ULBRICHT, H.-H. WAGNER and J. SCHMIDTMAYER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15562.x

    2. Use- and Voltage-Dependent Block of the Sodium Channel by Saxitoxin (pages 84–95)

      VINCENT L. SALGADO, JAY Z. YEH and TOSHIO NARAHASHI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15563.x

    3. On the Mechanism by Which Saxitoxin Binds to and Blocks Sodium Channels (pages 96–112)

      GARY STRICHARTZ, THOMAS RANDO, SHERWOOD HALL, JANE GITSCHIER, LINDA HALL, BARBARAJEAN MAGNANI and CHRISTINA HANSEN BAY

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15564.x

    4. Interactions of Scorpion Toxins with the Sodium Channel (pages 113–132)

      HANS MEVES, J. MARC SIMARD and DEAN D. WATT

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15565.x

    5. Toxins That Modulate the Sodium Channel Gating Mechanism (pages 133–151)

      TOSHIO NARAHASHI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15566.x

  4. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. The Sodium Channel from Electrophorus electricus (pages 162–178)

      S. R. LEVINSON, D. S. DUCH, B. W. URBAN and E. RECIO-PINTO

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15568.x

    2. Biochemistry of Sodium Channels from Mammalian Muscle (pages 179–185)

      ROBERT L. BARCHI

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15569.x

    3. Structure and Biosynthesis of Neuronal Sodium Channels (pages 186–203)

      WILLIAM A. CATTERALL, JOHN W. SCHMIDT, DONALD J. MESSNER and DANIEL J. FELLER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15570.x

    4. Polypeptide Toxins as Tools to Study Voltage-Sensitive Na+ Channels (pages 204–220)

      MICHEL LAZDUNSKI, CHRISTIAN FRELIN, JACQUES BARHANIN, ALAIN LOMBET, HAMUTAL MEIRI, DAVID PAURON, GEORGES ROMEY, ANNIE SCHMID, HUGUES SCHWEITZ, PAUL VIGNE and HENK P. M. VIJVERBERG

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15571.x

    5. Spatial Relations of the Neurotoxin Binding Sites on the Sodium Channel (pages 221–237)

      KIMON ANGELIDES, SUSUMU TERAKAWA and GEORGE B. BROWN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15572.x

  5. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. The Structure and Function of the Voltage-Sensitive Na Channel (pages 238–256)

      W. S. AGNEW, S. A. TOMIKO, R. L. ROSENBERG, M. C. EMERICK and E. C. COOPER

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15573.x

    2. Isochannels and Blocking Modes of Voltage-Dependent Sodium Channels (pages 269–292)

      EDWARD MOCZYDLOWSKI, AKIRA UEHARA, XIAOTAO GUO and JUDITH HEINY

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15575.x

    3. Functional Reconstitution of Purified Sodium Channels from Brain in Planar Lipid Bilayers (pages 293–305)

      ROBERT P. HARTSHORNE, BERNARD U. KELLER, JANE A. TALVENHEIMO, WILLIAM A. CATTERALL and MAURICIO MONTAL

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15576.x

    4. Surface Charges near the Guanidinium Neurotoxin Binding Site (pages 306–312)

      WILLIAM N. GREEN and OLAF S. ANDERSEN

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15577.x

  6. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. Genetic Variants of Voltage-Sensitive Sodium Channels (pages 313–324)

      LINDA M. HALL

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15578.x

    2. Analysis of Mutations Affecting Sodium Channels in Drosophila (pages 325–337)

      BARRY GANETZKY, KATE LOUGHNEY and CHUN-FANG WU

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15579.x

    3. Molecular Structure of Sodium Channels (pages 338–355)

      SHOSAKU NUMA and MASAHARU NODA

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15580.x

  7. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. Biosynthesis of Electroplax Sodium Channels (pages 356–363)

      WILLIAM B. THORNHILL and S. ROCK LEVINSON

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15581.x

    2. Distribution of Sodium Channels in Muscle (pages 364–376)

      J. H. CALDWELL

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15582.x

    3. Distribution and Mobility of Voltage-gated Ion Channels in Skeletal Muscle (pages 377–384)

      W. M. ROBERTS, W. STÜHMER, R. E. WEISS, P. R. STANFIELD and W. ALMERS

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15583.x

  8. PART VII. PANEL DISCUSSION

    1. Top of page
    2. Preface
    3. PART I. HISTORICAL PERSPECTIVES & CHEMISTRY OF TETRODOTOXIN & SAXITOXIN
    4. PART II. INTERACTION OF TETRODOTOXIN, SAXITOXIN & OTHER TOXINS WITH SODIUM CHANNEL
    5. PART III. BIOCHEMICAL CHARACTERIZATION OF ISOLATED CHANNELS
    6. PART IV. RECONSTITUTION OF CHANNELS INTO ARTIFICIAL MEMBRANES
    7. PART V. MOLECULAR GENETIC STUDIES OF CHANNEL BIOLOGY
    8. PART VI. CELLULAR ASPECTS OF SODIUM CHANNELS
    9. PART VII. PANEL DISCUSSION
    1. Future Directions in Sodium Channel Research (pages 439–445)

      S. R. LEVINSON, ARTHUR KARLIN, H. RON KABACK, RICHARD D. KEYNES and CHARLES F. STEVENS

      Version of Record online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb15587.x

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