Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1986

Volume 485 Bioregulatory Functions of Thrombin

Pages 1–448

  1. Article

    1. Top of page
    2. Article
    3. Structure of Thrombin and Thrombin Derivatives
    4. Substrate Specificity and Active-Site Modeling of Thrombin
    5. Cellular Events Mediated by Thrombin
    6. Poster Papers
    1. In Memoriam : Marion I. Barnhart (page 1)

      DANIEL A. WALZ

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34561.x

    2. Introduction (pages 2–4)

      JOHN W. FENTON II, MARC SHUMAN and DANIEL A. WALZ

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34562.x

  2. Structure of Thrombin and Thrombin Derivatives

    1. Top of page
    2. Article
    3. Structure of Thrombin and Thrombin Derivatives
    4. Substrate Specificity and Active-Site Modeling of Thrombin
    5. Cellular Events Mediated by Thrombin
    6. Poster Papers
    1. Thrombin (pages 5–15)

      JOHN W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34563.x

    2. Proteolytic Derivatives of Thrombin (pages 16–26)

      JACQUES ELION, JEAN-PAUL BOISSEL, BERNARD LE BONNIEC, ANNIE BEZEAUD, MARTINE JANDROT-PERRUS, MARIE-JOSÈPHE RABIET and MARIE-CLAUDE GUILLIN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34564.x

    3. Difference in Enzymatic Properties between “Staphylothrombin” and Free α-Thrombin (pages 27–40)

      SHUN-ICHIRO KAWABATA, TAKASHI MORITA, TOSHIYUKI MIYATA, SHIGENORI KAIDA, HIDEO IGARASHI and SADAAKI IWANAGA

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34565.x

    4. Mechanisms for Inhibition of the Generation of Thrombin Activity by Sulfated Polysaccharides (pages 41–55)

      F. A. OFOSU, G. J. MODI, J. HIRSH, M. R. BUCHANAN and M. A. BLAJCHMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34566.x

    5. Congenitally Abnormal Prothrombin and Thrombin (pages 56–65)

      MARIE-CLAUDE GUILLIN, ANNIE BEZEAUD, MARIE-JOSÈPHE RABIET and JACQUES ELION

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34567.x

    6. The Prothrombin Gene and Serine Proteinase Evolution (pages 66–72)

      SANDRA J. FRIEZNER DEGEN and EARL W. DAVIE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34568.x

    7. Recombinant Genetic Approaches to Functional Mapping of Thrombin (pages 73–79)

      ROSS T. A. MacGILLIVRAY, DAVID M. IRWIN, ENRIQUETA R. GUINTO and JAMES C. STONE

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34569.x

  3. Substrate Specificity and Active-Site Modeling of Thrombin

    1. Top of page
    2. Article
    3. Structure of Thrombin and Thrombin Derivatives
    4. Substrate Specificity and Active-Site Modeling of Thrombin
    5. Cellular Events Mediated by Thrombin
    6. Poster Papers
    1. Thrombin: Active-Site Topography (pages 80–95)

      LAWRENCE J. BERLINER, JENS J. BIRKTOFT, THEODORE L. MILLER, GIOVANNI MUSCI, JULIE E. SCHEFFLER, YUAN YUAN SHEN and YOSHIAKI SUGAWARA

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34570.x

    2. Heparin Binding in Proximity to the Catalytic Site of Human α-Thrombin (pages 96–103)

      TIMOTHY A. OLSON, STEVEN A. SONDER, GEORGE D. WILNER and JOHN W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34571.x

    3. Structure-Function Relationships of Thrombin Based on the Computer-Generated Three-Dimensional Model of the B Chain of Bovine Thrombin (pages 104–119)

      DAVID H. BING, RICHARD J. FELDMANN and JOHN W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34572.x

    4. Specificity of Thrombin and Its Action on Fibrinogen (pages 120–123)

      BIRGER BLOMBÄCK

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34573.x

    5. Chemical Basis of Thrombin Interactions with Fibrinogen (pages 124–133)

      HAROLD A. SCHERAGA

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34574.x

    6. Effect of Fibrinogen and Ca2+ on the Thrombin-Catalyzed Proteolytic Event That Triggers Activation of Factor XIII (pages 134–139)

      JULES A. SHAFER, SIDNEY D. LEWIS, TODD J. JANUS and LASZLO LORAND

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34575.x

    7. Regulation of Thrombin Cleavage of Plasma Factor XIII Bound to Fibrin (pages 140–143)

      CHARLES S. GREENBERG, KOMANDOOR E. ACHYUTHAN, CHARLES C. MIRAGLIA and JOSEPH V. DOBSON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34576.x

    8. Activation of Blood Coagulation Factor XIII (pages 144–158)

      LASZLO LORAND

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34577.x

    9. Thrombin/Prothrombin Interactions with Very Low Density Lipoproteins (pages 159–169)

      WILLIAM A. BRADLEY, JIAN-NAN SONG and SANDRA H. GIANTURCO

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34578.x

    10. Choices among the Possible Reaction Routes Catalyzed by Thrombin (pages 170–183)

      RAYMUND MACHOVICH

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34579.x

    11. Novel Immunoenzyme Assays for Thrombin-Antithrombin III and Thrombin-α2-Macroglobulin Complexes in Plasma (pages 184–198)

      PETER C. HARPEL and JOHN W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34580.x

    12. Nontoxic Irreversible Inhibitors of Factors IXa, Xa, and Thrombin: Potential Therapeutic Agents for the in Vivo Regulation of Thrombin Generation and Activity (pages 199–203)

      SALVATORE V. PIZZO, A. DENISE TURNER, STEVEN L. GONIAS, DOUGALD M. MONROE, HAROLD R. ROBERTS and NED A. PORTER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34581.x

    13. Pharmacological Approaches to Thrombin Regulation (pages 204–214)

      F. MARKWARDT

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34582.x

    14. Interaction of Thrombin with Thrombomodulin (pages 215–220)

      C. T. ESMON, N. L. ESMON, S. KUROSAWA and A. E. JOHNSON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34583.x

    15. Complex Interaction between Factor Va-Light Chain and Thrombomodulin in the Regulation of Protein C Activation (pages 221–227)

      HATEM H. SALEM, NAOMI L. ESMON, CHARLES T. ESMON and PHILIP W. MAJERUS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34584.x

  4. Cellular Events Mediated by Thrombin

    1. Top of page
    2. Article
    3. Structure of Thrombin and Thrombin Derivatives
    4. Substrate Specificity and Active-Site Modeling of Thrombin
    5. Cellular Events Mediated by Thrombin
    6. Poster Papers
    1. Thrombin-Cellular Interactions (pages 228–239)

      MARC A. SHUMAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34585.x

    2. Thrombin Interactions with Cultured Fibroblasts: Relationship to Mitogenic Stimulation (pages 240–248)

      DENNIS D. CUNNINGHAM and DAVID H. FARRELL

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34586.x

    3. Thrombin-Receptor Occupancy Initiates a Transient Increase in CAMP Levels in Mitogenically Responsive Hamster (NIL) Fibroblasts (pages 249–263)

      ERIC A GORDON, JOHN W. FENTON II and DARRELL H. CARNEY

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34587.x

    4. Effects of Thrombin on the Fibronectin-Containing Extracellular Matrix (pages 264–272)

      DEANE F. MOSHER and ELIZABETH D. THOMPSON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34588.x

    5. Thrombin and Chymotrypsin Interactions with Thrombospondin (pages 273–287)

      JACK LAWLER, JOSEPH E. CONNOLLY, PAULA FERRO and LAURA H. DERICK

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34589.x

    6. Thrombin Cleavage of Extracellular Matrix Proteins (pages 288–292)

      RONALD H. GOLDFARB and LANCE A. LIOTTA

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34590.x

    7. Thrombin-Induced Alterations in Endothelial Permeability (pages 293–309)

      ASRAR B. MALIK, SIU K. LO and RENA BIZIOS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34591.x

    8. Thrombin Interactions with Central Nervous System Tissue and Implications of These Interactions (pages 314–322)

      EUGENE D. MEANS and DOUGLAS K. ANDERSON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34593.x

    9. Responses of Aortic Smooth Muscle to Thrombin and Thrombin Analogues (pages 323–334)

      DANIEL A. WALZ, GORDON F. ANDERSON and JOHN W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34594.x

    10. Hormone-Like Activity of Human Thrombin (pages 335–348)

      RACHEL BAR-SHAVIT, KEITH A. HRUSKA, ARNOLD J. KAHN and GEORGE D. WILNER

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34595.x

    11. The Role of Thrombin in Transcellular Metabolism of Eicosanoids (pages 369–373)

      AARON J. MARCUS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34597.x

    12. Thrombin Interactions with Platelet Membrane Proteins (pages 374–386)

      M. C. BERNDT, C. GREGORY, G. DOWDEN and P. A. CASTALDI

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34598.x

    13. Platelet Activation by α-Thrombin Is a Receptor-Mediated Event (pages 387–395)

      JOAN T. HARMON and G. A. JAMIESON

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34599.x

    14. Thrombin-Induced Fibronectin Binding to Rat Platelets: Relationship to Other Inducing Agents (pages 396–399)

      R. E. CIAGLOWSKI, D. G. MOON, L. K. WESTON and J. E. KAPLAN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34600.x

    15. Concluding Remarks (pages 400–405)

      WALTER H. SEEGERS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34601.x

  5. Poster Papers

    1. Top of page
    2. Article
    3. Structure of Thrombin and Thrombin Derivatives
    4. Substrate Specificity and Active-Site Modeling of Thrombin
    5. Cellular Events Mediated by Thrombin
    6. Poster Papers
    1. Proteolysis of Human α-Thrombin by Human Neutrophil Elastase Results in Decreased Fibrinogen Clotting and Platelet-Stimulatory Activity (pages 406–407)

      MARK S. BROWER, KIMBERLY E. GARRY and JOHN W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34602.x

    2. Effect of Terbium on Thrombin and Antithrombin-Thrombin Interaction (pages 408–410)

      D. DEL PRINCIPE, A. MENICHELLI, A.M. FIORENTINO, C. COLISTRA, P.M. STRAPPINI and A. FINAZZI-AGRO

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34603.x

    3. A New Form of Proteolyzed Bovine Thrombin (pages 411–413)

      BRIAN F. P. EDWARDS, VINOD KUMAR, BARBARA A. BEDFORD, PHILIP D. MARTIN and RAJU D. KUNJUMMEN

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34604.x

    4. Inhibition of Tissue Plasminogen Activator by Protein or Synthetic Thrombin Inhibitors (pages 414–417)

      N. GILBOA and J. W. FENTON II

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34605.x

    5. Modulation of Thrombin Activity by Zinc (pages 421–424)

      GERARD MARX

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34607.x

    6. Proimmune Activity of Thrombin (pages 425–431)

      GERARD MARX

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34608.x

    7. Thrombin-Induced Increase in Pulmonary Endothelial Permeability in Vitro: Protective Effect of Isoproterenol (pages 432–435)

      FRED L. MINNEAR, DUDLEY G. MOON and LORI A. HILL

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34609.x

    8. S-Protein Modulates the Inactivation of Thrombin by Antithrombin III-Heparin (pages 436–438)

      KLAUS T. PREISSNER and G. MÜLLER-BERGHAUS

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34610.x

    9. Effect of Deuterium Oxide on Thrombin-Activated Fibrinogen Clotting (pages 445–446)

      CHARLES R. SPILLERT, KATE R. SPILLERT, JOHN C. KERR and ERIC J. LAZARO

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34613.x

    10. Structured Base of Thrombin-Regulating Functions in Hemostasis (pages 447–448)

      S. M. STRUKOVA, B. A. UMAROVA, E. G. KIREEVA, E. F. LUKYANENKO and B. A. KUDRYASHOV

      Article first published online: 16 DEC 2006 | DOI: 10.1111/j.1749-6632.1986.tb34614.x

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