Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

June 1988

Volume 531 Neurological Applications of Implanted Drug Pumps

Pages ix–ix, 1–214

  1. Preface

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Preface (page ix)

      RICHARD D. PENN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31805.x

  2. Introductory Lecture

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Function of Neuropeptides in the Central Nervous System (pages 1–8)

      JOSEPH B. MARTIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31806.x

  3. Part I. Diffusion and Circulation of Substances in the Brain

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Cerebrospinal Fluid Circulation and the Blood-Brain Barrier (pages 9–14)

      WILLIAM R. SHAPIRO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31807.x

    2. Neuroactive Substances in Cerebrospinal Fluid : Normal and Pathological Regulatory Mechanisms (pages 15–28)

      ROBERT M. POST, DAVID R. RUBINOW, MITCHEL A. KLING, WADE BERRETTINI and PHILIP W. GOLD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31808.x

    3. Drug “Diffusion” within the Brain (pages 29–39)

      JOSEPH FENSTERMACHER and THOMAS KAYE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31809.x

    4. Which Drugs, What Space? (pages 40–47)

      JEFFREY S. KROIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31810.x

  4. Part II. Drug Pump Technology

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. A New Implantable Drug Delivery System for Patient-Controlled Analgesia (pages 48–56)

      GERRIT KONING and FREDERICK FEITH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31811.x

    2. Shiley Infusaid Pump Technology (pages 57–65)

      JIM JOHNSTON, SANFORD REICH, ANTHONY BAILEY and JIM SLUETZ

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31812.x

    3. MiniMed Technologies Programmable Implantable Infusion System (pages 66–71)

      PETER LORD, HOSSEIN ALLAMI, MARK DAVIS, RAUL DIAZ, PATRICE HECK and ROBERT FISCHELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31813.x

    4. Medtronic SynchroMed Drug Administration System (pages 72–75)

      KENNETH T. HERUTH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31814.x

  5. Part III. Spinal Applications: Section A. Pain

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Dorsal Horn Neurophysiology of Pain (pages 76–89)

      WILLIAM D. WILLIS JR.

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31815.x

    2. Receptors in the Dorsal Horn and Intrathecal Drug Administration (pages 90–107)

      T. L. YAKSH, D. M. GAUMANN and C. W. STEVENS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31816.x

    3. Intraspinal Analgesic Infusion by Implanted Pump (pages 108–122)

      DENNIS W. COOMBS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31817.x

    4. Intrathecal Somatostatin (pages 133–145)

      JOACHIM CHRUBASIK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31819.x

  6. Part III. Spinal Applications: Section B. Spasticity

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. The Physiology of Spasticity and Its Response to Therapy (pages 146–149)

      ROBERT R. YOUNG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31820.x

    2. Dorsal Horn Neuropharmacology: Baclofen and Morphine (pages 150–156)

      W. ZIEGLGÄNSBERGER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31821.x

    3. Intrathecal Baclofen for Severe Spasticity (pages 157–166)

      RICHARD D. PENN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31822.x

    4. Intrathecal Baclofen in Tetanus (pages 167–173)

      H. MÜLLER, J. ZIERSKI, U. BÖRNER and G. HEMPELMANN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31823.x

  7. Part IV. Brain Applications: Section A. Alzheimer's Disease

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. New Intrathecal Drugs in Alzheimer's Disease and Psychometric Testing (pages 180–186)

      ROBERT S. WILSON and EILEEN M. MARTIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31825.x

  8. Part IV. Brain Applications: Section B. Neurotrophic Substances

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Prolonged Intrathecal Infusion of Thyrotropin Releasing Hormone in Amyotrophic Lateral Sclerosis (pages 187–193)

      THEODORE L. MUNSAT, JAMES TAFT, DAVID KASDON and IVOR M.D. JACKSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31826.x

  9. Part IV. Brain Applications: Section C. Parkinson's Disease

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Parkinsonism: Candidate Disorder for Implanted Pumps? (pages 194–199)

      JOHN G. NUTT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31827.x

    2. Possible Treatment of Parkinson's Disease with Intrathecal Medication in the MPTP Model (pages 200–205)

      TERRY W. HOOD, EDWARD F. DOMINO and HARRY S. GREENBERG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31828.x

  10. Part IV. Brain Applications: Section D. Brain Tumors

    1. Top of page
    2. Preface
    3. Introductory Lecture
    4. Part I. Diffusion and Circulation of Substances in the Brain
    5. Part II. Drug Pump Technology
    6. Part III. Spinal Applications: Section A. Pain
    7. Part III. Spinal Applications: Section B. Spasticity
    8. Part IV. Brain Applications: Section A. Alzheimer's Disease
    9. Part IV. Brain Applications: Section B. Neurotrophic Substances
    10. Part IV. Brain Applications: Section C. Parkinson's Disease
    11. Part IV. Brain Applications: Section D. Brain Tumors
    1. Use of Implantable Pump Systems for Intraarterial, Intraventricular and Intratumoral Treatment of Malignant Brain Tumors (pages 206–212)

      WILLIAM F. CHANDLER, HARRY S. GREENBERG, WILLIAM D. ENSMINGER, RICHARD F. DIAZ, LARRY R. JUNCK, TERRY W. HOOD, STEPHEN S. GEBARSKI and MICHAELYN A. PAGE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31829.x

    2. Intratumoral Chemotherapy with Multiple Sources (pages 213–214)

      GUY BOUVIER, RICHARD D. PENN, JEFFREY S. KROIN, RENÉ A. BÉIQUE, MARIE-JOSÉE GUÉRARD and JACQUES LESAGE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1988.tb31830.x

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