Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1989

Volume 573 Alpha-Keto Acid Dehydrogenase Complexes: Organization, Regulation, and Biomedical Ramifications

Pages xi–xviii, 1–462

    1. Preface (pages xi–xii)

      Mulchand S. Patel and Thomas E. Roche

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14980.x

    2. Opening Remarks (pages xiii–xiv)

      D. M. ZIEGLER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14981.x

    3. A Tribute to Lester J. Reed (pages xv–xviii)

      Thomas E. Roche

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14982.x

  1. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. 2-Oxo Acid Dehydrogenase Multienzyme Complexes: Domains, Dynamics, and Design (pages 1–20)

      RICHARD N. PERHAM and LEONARD C. PACKMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14983.x

    2. Intermediates in Reductive Transacetylation Catalyzed by Pyruvate Dehydrogenase Complex (pages 21–35)

      PERRY A. FREY, DOUGLAS S. FLOURNOY, KENNETH GRUYS and YUH-SHYONG YANG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14984.x

    3. Organization and Functioning of Muscle Pyruvate Dehydrogenase Active Centers (pages 36–54)

      L. S. KHAILOVA, L. G. KOROCHKINA and S. E. SEVERIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14985.x

    4. Properties of Lipoamide Dehydrogenase and Thioredoxin Reductase from Escherichia coli Altered by Site-Directed Mutagenesis (pages 55–65)

      CHARLES H. WILLIAMS JR., NIGEL ALLISON, GEORGE C. RUSSELL, ANDREW J. PRONGAY, L. DAVID ARSCOTT, SHOMPA DATTA, LENA SAHLMAN and JOHN R. GUEST

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14986.x

    5. The Lipoyl-Containing Components of the Mammalian Pyruvate Dehydrogenase Complex: Structural Comparison and Subdomain Roles (pages 66–75)

      THOMAS E. ROCHE, MOHAMMED RAHMATULLAH, SUSAN L. POWERS-GREENWOOD, GARY A. RADKE, S. GOPALAKRISHNAN and CHRISTINA L. CHANG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14987.x

  2. PART II. MOLECULAR CLONING OF COMPOMEMTS

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Structure, Expression, and Protein Engineering of the Pyruvate Dehydrogenase Complex of Escherichia coli (pages 76–99)

      JOHN R. GUEST, S. JANE ANGIER and GEORGE C. RUSSELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14988.x

    2. Molecular Cloning of cDNAs for α and β Subunits of Human Pyruvate Dehydrogenase (pages 100–112)

      KICHIKO KOIKE, YOSHISHIGE URATA and MASAHIKO KOIKE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14989.x

    3. Molecular Biology of the Human Pyruvate Dehydrogenase Complex: Structural Aspects of the E2 and E3 Components (pages 113–129)

      THOMAS J. THEKKUMKARA, GABRIEL PONS, SUMAIR MITROO, JOYCE E. JENTOFT and MULCHAND S. PATEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14990.x

    4. cDNA Cloning of the E1α Subunit of the Branshed-Chain α-Keto Acid Dehydrogenase and Elucidation of a Molecular Basis for Maple Syrup Urine Disease (pages 130–136)

      BEI ZHANG, MARTHA J. KUNTZ, GARY W. GOODWIN, HOWARD J. EDENBERG, DAVID W. CRABB and ROBERT A. HARRIS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14991.x

  3. PART III. REGULATION OF PURIFIED COMPLEXES

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Biochemical and Molecular Genetic Aspects of Pyruvate Dehydrogenase Complex from Saccharomyces cerevisiae (pages 155–167)

      LESTER J. REED, KAREN S. BROWNING, XIAO-DA NIU, ROBERT H. BEHAL and DAVID J. UHLINGER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14993.x

    2. Lipoyl-Containing Components of the Pyruvate Dehydrogenase Complex: Roles in Modulating and Anchoring the PDH Kinase and the PDH Phosphatase (pages 168–174)

      THOMAS E. ROCHE, MOHAMMED RAHMATULLAH, LIN LI, GARY A. RADKE, CHRISTINA L. CHANG and SUSAN L. POWERS-GREENWOOD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14994.x

    3. Regulation of the α-Keto Acid Dehydrogenase Complexes and Their Involvement in Primary Biliary Cirrhosis (pages 183–191)

      S. J. YEAMAN, M. F. BASSENDINE, D. FITTES, D. R. HODGSON, L. HESELTINE, H. J. BROWN, D. J. MUTIMER, O. F. W. JAMES and S. P. M. FUSSEY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14996.x

    4. Regulation of the Pyruvate Dehydrogenase Complexes in Plants (pages 192–205)

      DOUGLAS D. RANDALL, JAN A. MIERNYK, TUNG K. FANG, RAYMOND J. A. BUDDE and KATHRYN A. SCHULLER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14997.x

  4. PART IV. CELLULAR REGULATION

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. The Role of Ca2+ in the Hormonal Regulation of the Activities of Pyruvate Dehydrogenase and Oxoglutarate Dehydrogenase Complexes (pages 206–217)

      GUY A. RUTTER, JAMES G. McCORMACK, PETER J. W. MIDGLEY and RICHARD M. DENTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb14998.x

    2. Activation of Pyruvate Dehydrogenase Complex by Ca2+ in Intact Heart, Cardiac Myocytes, and Cardiac Mitochondria (pages 240–253)

      RICHARD G. HANSFORD, RAFAEL MORENO-SÁNCHEZ and BOHDAN LEWARTOWSKI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15001.x

  5. PART V. NUTRITIONAL AND HORMONAL CONTROL

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Insulin, Phospholipase, and the Activation of the Pyruvate Dehydrogenase Complex: An Enigma (pages 274–284)

      OTTO H. WIELAND, T. URUMOW and P. DREXLER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15004.x

    2. Studies into the Mechanism Whereby Insulin Activates Pyruvate Dehydrogenase Complex in Adipose Tissue (pages 285–296)

      RICHARD M. DENTON, PETER J. W. MIDGLEY, GUY A. RUTTER, ANDREW P. THOMAS and JAMES G. McCORMACK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15005.x

    3. Insulin Mediators and the Control of Pyruvate Dehydrogenase Complex (pages 297–305)

      J. LARNER, L. C. HUANG, S. SUZUKI, G. TANG, C. ZHANG, C. F. W. SCHWARTZ, G. ROMERO, L. LUTTRELL and A. S. KENNINGTON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15006.x

    4. Nutritional and Hormonal Regulation of the Activity State of Hepatic Branched-Chain α-Keto Acid Dehydrogenase Complex (pages 306–313)

      ROBERT A. HARRIS, GARY W. GOODWIN, RALPH PAXTON, PAUL DEXTER, STEVEN M. POWELL, BEI ZHANG, AMY HAN, YOSHIHARU SHIMOMURA and REID GIBSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15007.x

  6. PART VI. INBORN ERRORS

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Isolated and Combined Deficiencies of the α-Keto Acid Dehydrogenase Complexes (pages 337–346)

      BRIAN H. ROBINSON, KATHY CHUN, NEVENA MACKAY, GAIL OTULAKOWSKI, ROUMYANA PETROVA-BENEDICT and HUNT WILLARD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15009.x

    2. Genetic Defects in Human Pyruvate Dehydrogenase (pages 347–359)

      LAP HO, ISAIAH D. WEXLER, DOUGLAS S. KERR and MULCHAND S. PATEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15010.x

    3. The Clinical and Biochemical Spectrum of Human Pyruvate Dehydrogenase Complex Deficiency (pages 360–368)

      G. K. BROWN, R. M. BROWN, R. D. SCHOLEM, D. M. KIRBY and H-H. M. DAHL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15011.x

    4. Molecular Genetic Basis for Inherited Human Disorders of Branched-Chain α-Keto Acid Dehydrogenase Complex (pages 369–377)

      DEAN J. DANNER, STUART LITWER, W. JOSEPH HERRING and LOUIS J. ELSAS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15012.x

    5. Abnormalities of Pyruvate Dehydrogenase Complex in Brain Disease (pages 378–391)

      KWAN-FU REX SHEU, PAUL SZABO, LI-WEN KO and LOIS M. HINMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15013.x

  7. POSTER PAPERS: Characterization of Enzymes

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. The 2-Oxoglutarate Dehydrogenase Complex of Bacillus subtilis (pages 392–393)

      PETER CARLSSON and LARS HEDERSTEDT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15014.x

    2. Activation of Cauliflower α-Ketoglutarate Dehydrogenase Complex by Calcium Ions (pages 394–396)

      GEORGE A. KARAM and STEPHEN H. BISHOP

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15015.x

    3. Effect of Polyamines on Phosphorylation of Branched-Chain α-Keto Acid Dehydrogenase (pages 397–399)

      MARGARET L. MERRYFIELD and CARROLL B. DICKENS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15016.x

    4. Cross-Linking Studies of the Pyruvate Dehydrogenase Complex of Escherichia coli K-12 (pages 400–401)

      S. STEWART, J. BORVÁK, P. BOIVIN, T. TWOMEY and W. H. SCOUTEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15017.x

    5. Lipoamide Dehydrogenase in Serum: A Potential Diagnostic Tool (page 404)

      JOHN W. PELLEY and CHARLES A. BRADLEY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15019.x

  8. POSTER PAPERS: Development and Regulation

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Transport Regulation of Branched-Chain Amino Acid Oxidation (pages 405–406)

      SUSAN M. HUTSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15020.x

    2. Regulation of Gluconeogenesis in Renal Proximal Tubule Cells (pages 410–411)

      P. J. BUTTERWORTH and T. NAKAGAWA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15022.x

    3. Rapid Postnatal Induction of the Pyruvate Dehydrogenase Complex in Rat Liver Mitochondria (pages 412–415)

      ELENA SERRANO, ANA MARÍA LUIS, PILAR ENCABO, AGUSTÍN ALCONADA, LAP HO, MULCHAND S. PATEL and JOSÉ M. CUEZVA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15023.x

    4. Developmental Regulation of the Pyruvate Dehydrogenase Complex in the Rat Brain (page 416)

      G. D. A. MALLOCH, I. R. PHILLIPS and J. B. CLARK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15024.x

    5. Poly amines, Monoamines, and Amino Acids Alter Pyruvate Dehydrogenase Complex Activity in Mitochondria from Rat Adipocytes (pages 417–419)

      FREDERICK L. KIECHLE, JANET B. McGILL, DIANE M. DANDURAND and HALINA MALINSKI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15025.x

    6. Differential Inhibition of Mitochondrial Dehydrogenases by Fatty Acyl-CoAs (pages 420–422)

      JAMES C. K. LAI, KARIN RIMPEL-LAMHAOUAR and ARTHUR J. L. COOPER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15026.x

  9. POSTER PAPERS: Molecular Biology

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Oligonucleotide-Directed Mutagenesis of the lpd Gene of Escherichia coli (pages 429–431)

      G. C. RUSSELL, N. J. ALLISON, C. H. WILLIAMS JR. and J. R. GUEST

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15029.x

    2. Expression and Assembly of Active Bovine Dihydrolipoyl Transacylase (E2b) Precursor in Escherichia coli (pages 435–437)

      THOMAS A. GRIFFIN and DAVJD T. CHUANG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15031.x

    3. Gene Structure of the Promoter Region for the Human Pyruvate Dehydrogenase E1α Subunit and Regulation of Its Gene Expression (pages 438–440)

      SHIGEO OHTA, HITOSHI ENDO, KAKUKO MATSUDA and YASUO KAGAWA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15032.x

  10. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases

    1. Top of page
    2. PART I. ASSEMBLY, STRUCTURE, AND CATALYTIC MECHANISMS
    3. PART II. MOLECULAR CLONING OF COMPOMEMTS
    4. PART III. REGULATION OF PURIFIED COMPLEXES
    5. PART IV. CELLULAR REGULATION
    6. PART V. NUTRITIONAL AND HORMONAL CONTROL
    7. PART VI. INBORN ERRORS
    8. POSTER PAPERS: Characterization of Enzymes
    9. POSTER PAPERS: Development and Regulation
    10. POSTER PAPERS: Molecular Biology
    11. POSTER PAPERS: Molecular Basis of Genetic and Acquired Diseases
    1. Identification of the Acyltransferase (E2) Components of Branched-Chain α-Keto Acid Dehydrogenase and Pyruvate Dehydrogenase Complexes as Autoantigens in Primary Biliary Cirrhosis (pages 441–443)

      P. A. DAVIS, D. R. FREGEAU, J. VAN DE WATER, C. SURH, A. ANSARI, R. COPPELL, D. DANNER and M. E. GERSHWIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15033.x

    2. The Lipoate-Containing Domain of PDC E2 Contains the Main Immunogenic Region of the 70-kDa M2 Autoantigen in Primary Biliary Cirrhosis (pages 444–446)

      SHELLEY P. M. FUSSEY, MARGARET F. BASSENDINE, OLIVER F. W. JAMES and STEPHEN J. YEAMAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15034.x

    3. Molecular Phenotypes in Cultured Maple Syrup Urine Disease Cells (pages 453–454)

      CHARLES W. FISHER, JACINTA L. CHUANG, THOMAS A. GRIFFIN, KIM S. LAU, RODY P. COX and DAVID T. CHUANG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15037.x

    4. Cloning and Characterization of Human Pyruvate Dehydrogenase Genes (pages 455–457)

      B. J. SONG, Y. T. CHI, T. L. HUH, J. P. CASAZZA, B. SUMEGI, P. A. SRERE and R. L. VEECH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15038.x

    5. Identification of a Gene for the Pyruvate Dehydrogenase E1α Subunit with a Deletion of Four Nucleotides from a Patient with Pyruvate Dehydrogenase Complex Deficiency (pages 458–460)

      HITOSHI ENDO, KIYOSHI HASEGAWA, KUNIAKI NARISAWA, KEIYA TADA, YASUO KAGAWA and SHIGEO OHTA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1989.tb15039.x

SEARCH

SEARCH BY CITATION