Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

May 1990

Volume 589 Biochemical Engineering

Pages 1–712

  1. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Strategies and Challenges in Metabolic Engineering (pages 1–15)

      J. E. BAILEY, S. BIRNBAUM, J. L. GALAZZO, C. KHOSLA and J. V. SHANKS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24230.x

    1. Genetic Engineering of Metabolic Pathways Applied to the Production of Phenylalanine (pages 16–24)

      KEITH BACKMAN, MARY JANE O'CONNOR, AIKO MARUYA, EDWIN RUDD, DIANE McKAY, R. BALAKRISHNAN, M. RADJAI, V. DIPASQUANTONIO, DIANE SHODA, RANDOLPH HATCH and K. VENKATASUBRAMANIAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24231.x

    2. Stoichiometry and Kinetics of Xylose Fermentation by Pichia stipitis (pages 25–40)

      P. J. SLININGER, J. E. BRANSTRATOR, J. M. LOMONT, B. S. DIEN, M. R. OKOS, M. R. LADISCH and R. J. BOTHAST

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24232.x

    3. Improvement of Plasmid Stability by Immobilization of Recombinant Microorganisms (pages 41–53)

      JEAN-NOËL BARBOTIN, SAMI SAYADI, MONCEF NASRI, FADWA BERRY and DANIEL THOMAS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24233.x

    4. Regulation and Dynamics of Elicitor Response in Suspension-cultured Plant Cells (pages 54–66)

      S. Y. BYUN, H. PEDERSEN and C-K. CHIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24234.x

    5. Methods for Cloning Key Primary Metabolic Enzymes and Ancillary Proteins Associated with the Acetone-Butanol Fermentation of Clostridium acetobutylicum (pages 67–81)

      JEFFREY W. CARY, DANIEL J. PETERSEN, GEORGE N. BENNETT and E. T. PAPOUTSAKIS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24235.x

  2. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Optimal Induction of Protein Synthesis in Recombinant Bacterial Cultures (pages 121–138)

      WILLIAM E. BENTLEY and DHINAKAR S. KOMPALA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24239.x

    2. Expression, Purification, and Immobilization of a Protein A-β-Lactamase Hybrid Protein (pages 139–147)

      GEORGE GEORGIOU and FRANÇOIS BANEYX

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24240.x

  3. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. A Novel Immunoaffinity Chromatography System for the Purification of Therapeutic Proteins (pages 148–156)

      PETER GRANDICS, ZSOLT SZATHMARY and SUSAN SZATHMARY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24241.x

    1. New Approaches to the More Efficient Purification of Proteins and Enzymes (pages 157–171)

      N. J. TITCHENER-HOOKER, M. HOARE and P. DUNNILL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24242.x

    2. Gradient Elution in Preparative Liquid Chromatography (pages 172–181)

      FIROZ D. ANTIA and CSABA HORVÁTH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24243.x

    3. Purification of β-Galactosidase by Combined Frontal and Displacement Chromatography (pages 182–191)

      ABRAHAM LIAO and CSABA HORVÁTH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24244.x

  4. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Novel Membrane-based Immobilization Technique for Bioreactors (pages 192–202)

      W. K. KANG, R. SHUKLA and K. K. SIRKAR

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24245.x

    1. Separation of Amino Acids Using Composite Ion Exchange Membranes (pages 203–213)

      BINAY K. DUTTA and SUBHAS K. SIKDAR

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24246.x

    2. Studies of Transport Processes Coupled with Reaction in Membrane-sandwiched Yeast Cell Reactors (pages 214–228)

      YONG S. JEONG, W. R. VIETH and TAKESHI MATSUURA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24247.x

    3. Chitin-Chitosan Membranes : Separations of Amino Acids and Polypeptides (pages 229–244)

      JOHN J. PELLEGRINO, STUART GEER, KAREN MAEGLEY, RAPHAEL RIVERA, DARLENE STEWARD and MYONG KO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24248.x

    4. Diffusion of Proteins in Porous Membranes (pages 245–252)

      RUTH E. BALTUS and ZHONG LU

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24249.x

    5. A Continuous Enzyme Membrane Reactor Retaining the Native Nicotinamide Cofactor NAD(H) (pages 253–260)

      MICHAEL W. HOWALDT, KLAUS D. KULBE and HORST CHMIEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24250.x

    6. Covalently Attached GRGD on Polymer Surfaces Promotes Biospecific Adhesion of Mammalian Cells (pages 261–270)

      STEPHEN P. MASSIA and JEFFREY A. HUBBELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24251.x

  5. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. The Hyperthermophilic Archaebacterium, Pyrococcus furiosus : Development of Culturing Protocols, Perspectives on Scaleup, and Potential Applications (pages 301–314)

      I. I. BLUMENTALS, S. H. BROWN, R. N. SCHICHO, A. K. SKAJA, H. R. COSTANTINO and R. M. KELLY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24254.x

    2. Nutrient Transport and Cellular Morphology in Immobilized Cell Aggregates (pages 333–349)

      J. D. FOWLER and C. R. ROBERTSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24256.x

    3. Fermentation Development of Recombinant Pichia pastoris Expressing the Heterologous Gene: Bovine Lysozyme (pages 350–362)

      R. A. BRIERLEY, C. BUSSINEAU, R. KOSSON, A. MELTON and R. S. SIEGEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24257.x

    4. Large-Scale Growth of Bordetella pertussis for Production of Extracellular Toxin (pages 363–371)

      N. ANDORN, J. B. KAUFMAN, T. R. CLEM, R. FASS and J. SHILOACH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24258.x

  6. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Growth Kinetics of Free and Immobilized Insect Cell Cultures (pages 372–398)

      S. N. AGATHOS, Y-H. JEONG and K. VENKAT

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24259.x

    1. Bioreactor Development for Production of Viral Pesticides or Heterologous Proteins in Insect Cell Cultures (pages 399–422)

      M. L. SHULER, T. CHO, T. WICKHAM, O. OGONAH, M. KOOL, D. A. HAMMER, R. R. GRANADOS and H. A. WOOD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24260.x

    2. Production of Baculovirus in a Continuous Insect-Cell Culture : Bioreactor Design, Operation, and Modeling (pages 423–430)

      J. TRAMPER, E. J. van den END, C. D. de GOOIJER, R. KOMPIER, F. L. J. van LIER, M. USMANY and J. M. VLAK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24261.x

    3. Effects of Microcarriers and Serum on Local Hydrodynamics within an Airlift Column (pages 431–442)

      G. T. JONES, L. E. ERICKSON and L. A. GLASGOW

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24262.x

  7. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Nuclear Magnetic Resonance Methods for Observing the Intracellular Environment of Mammalian Cells (pages 458–475)

      ERIK J. FERNANDEZ, ANTHONY MANCUSO, MARILEE K. MURPHY, HARVEY W. BLANCH and DOUGLAS S. CLARK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24264.x

    1. Scanning Tunneling Microscopy and Atomic Force Microscopy of Biological Surfaces (pages 476–491)

      JOSEPH A. N. ZASADZINSKI and PAUL K. HANSMA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24265.x

    2. Uses of Fluorescence Sensors : For the Monitoring of Immobilized Cell Culture Fluorescence and as Optical Biosensors (pages 492–507)

      K-D. ANDERS, W. MÜLLER, T. SCHEPER and A. F. BÜCKMANN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24266.x

  8. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Multivariable Control of Continuous and Fed-Batch Bioreactors (pages 508–528)

      DANIEL WEI, SATISH J. PARULEKAR and WILLIAM A. WEIGAND

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24267.x

    1. Intelligent Purification of Monoclonal Antibodies (pages 529–539)

      P. W. THOMPSON, A. C. KENNEY, P. MOULDING and D. WORMALD

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24268.x

    2. L-Aspartic Acid Production Using Immobilized E. coli Cells in a Packed-Bed Reactor : Design of Reactor and Its Optimal Operation (pages 540–552)

      HIROYASU SEKO, SHINOBU TAKEUCHI, KAZUYOSHI YAJIMA, MASARU SENUMA and TETSUYA TOSA

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24269.x

    3. An Expert System for Cultivating Operations (pages 569–579)

      H. ASAMA, T. NAGAMUNE, M. HIRATA, A. HIRATA and I. ENDO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24271.x

    4. Analysis of Performance Limitations in Immobilized Cell Fermentors (pages 593–598)

      C. WEBB, G. A. DERVAKOS and J. F. DEAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24273.x

  9. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Scaleup and Optimization of Oxygen Transfer in Fermentors : Newtonian and Non-Newtonian Systems (pages 616–641)

      V. SINGH, R. FUCHS, W. HENSLER and A. CONSTANTINIDES

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24275.x

    2. Comparison of Cephalosporin C Production in Stirred-Tank and Airlift Tower Loop Reactors (pages 665–669)

      T. BAYER, T. HEROLD, K. HOLZHAUER, W. ZHOU and K. SCHÜGERL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24278.x

  10. PART X. IMMOBILIZED ENZYME BIOREACTORS

    1. Top of page
    2. PART I. MANIPULATION AND ANALYSIS OF METABOLIC PATHWAYS
    3. PART II. PROCESSES INVOLVING GENETICALLY ENGINEERED ORGANISMS
    4. PART III. PROTEIN SEPARATIONS AND DOWNSTREAM PROCESSING
    5. PART IV. MEMBRANE-BASED REACTIONS AND SEPARATIONS
    6. PART V. BIOREACTORS I (MICROBIAL SYSTEMS)
    7. PART VI. BIOREACTORS II (HIGHER EUKARYOTIC SYSTEMS)
    8. PART VII. BIOPROCESSING BIOSENSORS AND ANALYTICAL METHODS IN
    9. PART VIII. BIOPROCESS OPTIMIZATION AND CONTROL
    10. PART IX. MIXING AND SCALEUP OF BIOLOGICAL REACTORS
    11. PART X. IMMOBILIZED ENZYME BIOREACTORS
    1. Hydration of Cyanopyridine to Nicotinamide by Immobilized Nitrile Hydratase (pages 678–688)

      JACOB EYAL and MARVIN CHARLES

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24280.x

    1. Immobilized Pig Brain NAD Glycohydrolase for the Preparation of NAD Analogues (pages 689–696)

      MARIO PACE, PIER GIORGIO PIETTA, DARIO AGNELLINI, PIER LUIGI MAURI and SILVIA GHEZZI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24281.x

    2. Microbial Decarboxylation of Succinate to Propionate : Kinetic Studies (pages 697–704)

      NISSIM S. SAMUELOV, RATHIN DATTA, MAHENDRA K. JAIN and J. GREGORY ZEIKUS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24282.x

    3. Bacterial Enzymes in Halogenation Processes (pages 705–712)

      WOLFGANG WIESNER, MANFRED KARL OTTO and KLAUS DIETER KULBE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb24283.x

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