Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

December 1990

Volume 616 AIDS: Anti-HIV Agents, Therapies, and Vaccines

Pages xv–xv, 1–630

    1. Preface (page xv)

      VASSIL ST. GEORGIEV and JOHN J. McGOWAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17821.x

    2. Acquired Immune Deficiency Syndrome (AIDS) : Progress in Drug Research and Therapeutic Potential (pages 1–10)

      VASSIL ST. GEORGIEV and JOHN J. MCGOWAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17822.x

  1. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Structure-Function Studies of HIV Reverse Transcriptase (pages 11–21)

      VINAYAKA R. PRASAD and STEPHEN P. GOFF

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17823.x

    2. Comparative Studies of 2′,3′-Didehydro-2′,3′-Dideoxythymidine (D4T) with other Pyrimidine Nucleoside Analogues (pages 22–28)

      JOHN C. MARTIN, MICHAEL J. M. HITCHCOCK, ARNOLD FRIDLAND, ISMAIL GHAZZOULI, SANJEEV KAUL, LISA M. DUNKLE, ROMAN Z. STERZYCKI and MUZAMMIL M. MANSURI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17824.x

    3. Correlation of Molecular Conformation and Activity of Reverse Transcriptase Inhibitors (pages 29–40)

      PATRICK VAN ROEY, E. WILL TAYLOR, CHUNG K. CHU and RAYMOND F. SCHINAZI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17825.x

    4. HIV-1 Protease as a Potential Target for Anti-AIDS Therapy (pages 41–53)

      THOMAS D. MEEK and GEOFFREY B. DREYER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17826.x

    5. Molecular Interactions between Human Immunodeficiency Virus Type 1 and Human Cytomegalovirus (pages 54–63)

      PETER A. BARRY, ELISSA PRATT-LOWE, DONALD J. ALCENDOR, RONALD E. UNGER and PAUL A. LUCIW

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17827.x

    6. The Human Immunodeficiency Virus TAT Protein : A Target for Antiviral Agents (pages 64–72)

      IAIN S. SIM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17828.x

    7. Summary of Part I : Rational Targets for Design and Synthesis of Anti-HIV Agents (pages 86–89)

      MARK L. PEARSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17830.x

  2. Part II. Antireceptor Strategies in the Treatment of AIDS

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Inhibition of Glycoprotein Processing and HIV Replication by Castanospermine Analogues (pages 90–96)

      PRASAD S. SUNKARA, MOHINDER S. KANG, TERRY L. BOWLIN, PAUL S. LIU, A. STANLEY TYMS and ALBERT SJOERDSMA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17831.x

    2. The Genetic Analysis of the HIV Envelope Binding Domain on CD4 (pages 116–124)

      JAMES ARTHOS, KEITH C. DEEN, ALLAN SHATZMAN, ALEMSEGED TRUNEH, MARTIN ROSENBERG and RAYMOND W. SWEET

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17833.x

    3. Peptides Derived from the CDR3-Homologous Domain of the CD4 Molecule Are Specific Inhibitors of HIV-1 and SIV Infection, Virus-Induced Cell Fusion, and Postinfection Viral Transmission in Vitro : Implications for the Design of Small-Peptide Anti-HIV Therapeutic Agents (pages 125–128)

      D. M. RAUSCH, K. M. HWANG, M. PADGETT, A.-H. VOLTZ, A. RIVAS, E. ENGLEMAN, I. GASTON, M. McGRATH, B. FRASER, V. S. KALYANARAMAN, P. L. NARA, N. DUNLOP, L. MARTIN, M. MURPHEY-CORB, TRACY KIBORT, J. D. LIFSON and L. E. EIDEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17834.x

    4. Anti-HIV Effects of CD4-Pseudomonas Exotoxin on Human Lymphocyte and Monocyte/Macrophage Cell Lines (pages 149–154)

      PER ASHORN, BERNARD MOSS and EDWARD A. BERGER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17835.x

    5. Early Events of HIV Infection as Targets for Antiviral Agents (pages 155–160)

      R. DATEMA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17836.x

  3. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Innovations in the Use of Antisense Oligonucleotides (pages 161–172)

      GERALD ZON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17837.x

    2. Ribozymes as Therapies for AIDS (pages 184–200)

      JOHN J. ROSSI, EDOUARD M. CANTIN, JOHN A. ZAIA, PAULA A. LADNE, JIAN CHEN, DELILAH A. STEPHENS, NAVA SARVER and PAIROJ S. CHANG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17839.x

    3. Antisense and Antiviral Therapy (pages 201–204)

      MICHAEL I. SHERMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17840.x

  4. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Metabolism in Human Leukocytes of Anti-HIV Dideoxypurine Nucleosides (pages 205–216)

      ARNOLD FRIDLAND, MARK A. JOHNSON, DAVID A. COONEY, G. AHLUWALIA, VICTOR E. MARQUEZ, JOHN S. DRISCOLL and DAVID G. JOHNS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17841.x

    2. DNA Polymerases versus HIV Reverse Transcriptase in AIDS Therapy (pages 217–223)

      YUNG-CHI CHENG, WEN-YI GAO, CHIN-HO CHEN, MIGUEL VAZQUEZ-PADUA and MILBREY C. STARNES

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17842.x

    3. Antiviral Drug Resistance (pages 224–236)

      DONALD M. COEN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17843.x

    4. Use of a Neonatal Murine Retrovirus Model To Evaluate the Long-Term Efficacy and Toxicity of Antiviral Agents (pages 238–251)

      J. A. BILELLO, C. MacaULEY, T. N. FREDRICKSON, M. M. BELL, C. McKISSICK, S. G. SHAPIRO, R. PERSONETTE and J. L. EISEMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17844.x

    5. Strategies to Inhibit Viral Polyprotein Cleavages (pages 252–257)

      BRUCE D. KORANT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17845.x

    6. Therapy of Presymptomatic FeLV-Induced Immunodeficiency Syndrome with AZT in Combination with Alpha Interferon (pages 258–269)

      EDWARD A. HOOVER, NORDIN S. ZEIDNER and JAMES I. MULLINS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17846.x

    7. Evidence for HIV-1 Infection in Rabbits : A Possible Model for AIDS (pages 270–280)

      M. R. GORDON, M. E. TRUCKENMILLER, D. P. RECKER, D. R. DICKERSON, E. KUTA, H. KULAGA and T. J. KINDT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17847.x

    8. Preclinical Evaluation of Antiviral Compounds in the SCID-hu Mouse (pages 281–286)

      J. McCUNE, H. KANESHIMA, L. RABIN, C.-C. SHIH and R. NAMIKAWA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17848.x

    9. Nonhuman Primate Models for Evaluation of AIDS Therapy (pages 287–298)

      HAROLD M. McCLURE, DANIEL C. ANDERSON, AFTAB A. ANSARI, PATRICIA N. FULTZ, SHERRY A. KLUMPP and RAYMOND F. SCHINAZI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17849.x

  5. Part V. Immunotherapies for the Treatment of AIDS

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Pharmacology of Antiretroviral Drugs : Lessons Learned to Date (pages 299–306)

      PAUL S. LIETMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17850.x

    2. Impaired Immunity in AIDS : The Mechanisms Responsible and Their Potential Reversal by Antiviral Therapy (pages 307–317)

      CURTIS L. RUEGG and EDGAR G. ENGLEMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17851.x

  6. Part VI. Clinical Evaluation of Anti-HIV Drugs

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. New Developments in Combination Chemotherapy of Anti-Human Immunodeficiency Virus Drugs (pages 318–327)

      VICTORIA A. JOHNSON and MARTIN S. HIRSCH

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17852.x

    2. Initial Clinical Experience with Dideoxynucleosides as Single Agents and in Combination Therapy (pages 328–343)

      ROBERT YARCHOAN, JAMES M. PLUDA, CARLO FEDERICO PERNO, HIROAKI MITSUYA, ROSE V. THOMAS, KATHY M. WYVILL and SAMUEL BRODER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17853.x

    3. Summary of Part VI : Clinical Evaluation of Anti-HIV Drugs (pages 344–345)

      CARLOS LOPEZ

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17854.x

  7. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Characterization of Reverse Transcriptase Activity and Susceptibility to Other Nucleosides of AZT-Resistant Variants of HIV-1 : Results from the Canadian AZT Multicentre Study (pages 346–355)

      MARK A. WAINBERG, MICHEL TREMBLAY, RONALD ROOKE, NORMAND BLAIN, HUGO SOUDEYNS, MICHAEL A. PARNIAK, X-J YAO, X-G LI, MARY FANNING, JULIO S. G. MONTANER, MICHAEL O'SHAUGHNESSY, CHRISTOS TSOUKAS, JULIAN FALUTZ, GERVAIS DIONNE, BERNARD BELLEAU and JOHN RUEDY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17855.x

  8. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Pharmacologic Studies of Nucleosides Active against the Human Immunodeficiency Virus (pages 356–366)

      JEAN-PIERRE SOMMADOSSI, ZHOU ZHU, RICARDA CARLISLE, MENG-YU XIE and DOUGLAS A. WEIDNER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17856.x

    2. Synergistic Drug Combinations in AIDS Therapy : Dipyridamole/3′-Azido-3′-Deoxythymidine in Particular and Principles of Analysis in General (pages 367–384)

      JOHN N. WEINSTEIN, BARRY BUNOW, OWEN S. WEISLOW, RAYMOND F. SCHINAZI, SHARON M. WAHL, LARRY M. WAHL and JANOS SZEBENI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17857.x

    3. Antiretroviral Activity, Biochemistry, and Pharmacokinetics of 3′-Azido-2′,3′-Dideoxy-5-Methylcytidine (pages 385–397)

      R. F. SCHINAZI, C. K. CHU, B. F. ERIKSSON, J.-P. SOMMADOSSI, K. J. DOSHI, F. D. BOUDINOT, B. OSWALD and H. M. McCLURE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17858.x

    4. Biochemical Pharmacology of Acyclic Nucleotide Analogues (pages 398–407)

      JOANNE J. BRONSON, HSU-TSO HO, HILDE DE BOECK, KATHLEEN WOODS, ISMAIL GHAZZOULI, JOHN C. MARTIN and MICHAEL J. M. HITCHCOCK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17859.x

    5. Anabolism and Mechanism of Action of Ro24-5098, an Isomer of 2′,3′-Dideoxyadenosine (ddA) with Anti-HIV Activity (pages 408–414)

      KARL B. FRANK, EDWARD V. CONNELL, MICHAEL J. HOLMAN, DONNA M. HURYN, BARBARA C. SLUBOSKI, STEVE Y. TAM, LOUIS J. TODARO, MANFRED WEIGELE, DOUGLAS D. RICHMAN, HIROAKI MITSUYA, SAMUEL BRODER and IAIN S. SIM

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17860.x

  9. Part VIII. Opportunistic Infections in AIDS Patients

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Molecular Biology of Pneumocystis carinii (pages 415–420)

      MELANIE T. CUSHION, SUNG TAE HONG, PAUL E. STEELE, SAUNDRA L. STRINGER, PETER D. WALZER and JAMES R. STRINGER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17861.x

    2. Development of Pentamidine Analogues as New Agents for the Treatment of Pneumocystis carinii Pneumonia (pages 421–441)

      RICHARD R. TIDWELL, SUSAN K. JONES, J. DIETER GERATZ, KWASI A. OHEMENG, CONSTANCE A. BELL, BRADLEY J. BERGER and JAMES EDWIN HALL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17862.x

    3. Treatment Strategies for Cryptosporidiosis (pages 442–451)

      ROSEMARY SOAVE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17863.x

    4. Novel Pharmacological Strategies in the Treatment of Life-Threatening Cytomegalovirus Infections : Clinical Experience with Continuous Infusion 9-(1,3-Dihydroxy-2-Propoxymethyl) Guanine (pages 452–460)

      RICHARD J. WHITLEY, JOAN CONNELL, MICHAEL A. MARKIEWICZ and JEAN-PIERRE SOMMADOSSI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17864.x

    5. Fungal Infections in HIV Patients (pages 461–468)

      CHARLES H. KIRKPATRICK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17865.x

    6. Summary of Part VIII : An Overview of Opportunistic Infections in AIDS Patients (pages 469–471)

      DAVID LOEBENBERG, JEROME SCHWARTZ and FRANCIS J. BULLOCK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17866.x

  10. Part IX. Poster Papers

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Kinetics of ddI in Plasma, Brain, and CSF of Rats after Administration of ddI and an Ester Prodrug of ddI (pages 472–474)

      BRADLEY D. ANDERSON, BARBARA L. HOESTEREY, DAVID C. BAKER and RAYMOND E. GALINSKY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17867.x

    2. Mechanism of Uptake of 3′-Deoxythymidin-2′-ene (d4T) in Human Lymphocyte H9 Cells (pages 475–476)

      E. MICHAEL AUGUST and WILLIAM H. PRUSOFF

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17868.x

    3. Continuous Optical Assays for DNA Polymerases and Reverse Transcriptases (pages 477–479)

      JEAN G. BAILLON, NASHAAT T. NASHED, JANE M. SAYER and DONALD M. JERINA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17869.x

    4. An Improved Sulfurization Reagent for the Synthesis of Sulfur-Containing Oligonucleotides (pages 483–485)

      SERGE L. BEAUCAGE, RADHAKRISHNAN P. IYER, WILLIAM EGAN and JUDITH B. REGAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17871.x

  11. PART IX. POSTER PAPERS

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Therapeutic Activity of Reverse Transcriptase Inhibitors in Murine Retrovirus Models (pages 486–490)

      PAUL L. BLACK, MICHAEL A. USSERY, JAMES T. RANKIN JR. and MICHAEL A. CHIRIGOS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17872.x

    2. COMBO: A New Approach to the Analysis of Drug Combinations in Vitro (pages 490–494)

      BARRY BUNOW and JOHN N. WEINSTEIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17873.x

  12. Part IX. Poster Papers

    1. Top of page
    2. Part I: Rational Targets for Design and Synthesis of Anti-HIV Agents
    3. Part II. Antireceptor Strategies in the Treatment of AIDS
    4. Part III. Novel Uses of Antiviral Therapeutics in the Treatment of AIDS
    5. Part IV. Biochemistry and Evaluation of Anti-HIV Therapeutics
    6. Part V. Immunotherapies for the Treatment of AIDS
    7. Part VI. Clinical Evaluation of Anti-HIV Drugs
    8. Part VII. Papers from Panel Discussion: Pharmacology and Metabolism of Anti-HIV Drugs
    9. PART VII. PAPERS FROM PANEL DISCUSSION: PHARMACOLOGY AND METABOLISM OF ANTI-HIV DRUGS
    10. Part VIII. Opportunistic Infections in AIDS Patients
    11. Part IX. Poster Papers
    12. PART IX. POSTER PAPERS
    13. Part IX. Poster Papers
    1. Brain Targeting of Anti-HIV Nucleosides : Synthesis and in Vivo Studies of Dihydronicotinyl Derivatives of AzddU (AZDU or CS-87) and AZT (pages 495–498)

      C. K. CHU, V. S. BHADTI, K. J. DOSHI, J. T. ETSE, J. M. GALLO, F. D. BOUDINOT and R. F. SCHINAZI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17874.x

    2. Synthesis and Evaluation of a Triphenylcarbinol Related to the Incorrectly Assumed Structure of Aurintricarboxylic Acid (pages 499–502)

      MARK CUSHMAN and SUSEELA KANAMATHAREDDY

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17875.x

    3. An Approach to the Synthesis of HIV Protease Inhibitors : Stereochemically Pure Peptide Substrate Analogues Containing [Phe-ΨCH2N-Pro] Linkages (pages 503–507)

      MARK CUSHMAN, YOUNG-IM OH, TERRY D. COPELAND, STUART W. SNYDER and STEPHEN OROSZLAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17876.x

    4. Effect of Derivatized Nucleotide Antiviral Drugs on HIV-1 Replication in Cells of T-Lymphoblastoid and Monocyte/Macrophage Lineage in Vitro (pages 508–510)

      M. I. DAWSON, H. ABRAMS, A. SATYAM, S. TORKELSON, B. ROSS, A. SHIBA, M. REEVE, D. GEORGE, I. GASTON, M. McGRATH and J. LIFSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17877.x

    5. Porphyrins as Agents against the Human Immunodeficiency Virus (pages 511–513)

      DABNEY W. DIXON, RAYMOND SCHINAZI and LUIGI G. MARZILLI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17878.x

    6. Expression in E. coli and Purification of Human Immunodeficiency Virus Type 1 Major Core Protein, p24 (pages 514–516)

      LORNA S. EHRLICH, HANS-GEORG KRAÜSSLICH, ECKARD WIMMER and CAROL A. CARTER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17879.x

    7. Metabolism, Toxicity, and Anti-HIV Activity of 2′-Deoxy-3′-Thia-Cytidine (BCH-189) in T and B Cell Lines (pages 517–518)

      MICHAEL L. GREENBERG, H. S. ALLAUDEEN and MICHAEL S. HERSHFIELD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17880.x

    8. Ultrastructural and Cytochemical Analysis of the Loss of Envelope Glycoproteins (gp120) on Budding and Mature HIV-1 following Treatment with Soluble T4 (sT4) (pages 519–522)

      TIMOTHY K. HART, RICHARD KIRSH, ANNE M. KLINKNER, DENNIS M. LAMBERT, S. R. PETTEWAY JR., HARMA ELLENS and PETER J. BUGELSKI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17881.x

    9. Pharmacokinetic Study of Dextran Sulfate in Rats (pages 523–525)

      NEIL R. HARTMAN, DAVID G. JOHNS and HIROAKI MITSUYA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17882.x

    10. Anti-HIV-1, Cytotoxic, and Biological Properties of Selected Polyoxometalate Compounds (pages 528–529)

      C. L. HILL, M. WEEKS, M. HARTNUP, J-P. SOMMADOSSI and R. F. SCHINAZI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17884.x

    11. Synthesis and Anti-HIV Activity of a Novel Series of Isomeric Dideoxynucleosides (pages 530–534)

      D. M. HURYN, B. C. SLUBOSKI, S. Y. TAM, L. J. TODARO, M. WEIGELE, I. S. SIM, K. B. FRANK, D. D. RICHMAN, H. MITSUYA and S. BRODER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17885.x

    12. Improved Synthesis of (−)-Carbovir, GR90352X, a Potent and Selective Inhibitor of HIV-1 in Vitro (pages 535–537)

      M. F. JONES, C. L. MO, P. L. MYERS, I. L. PATERNOSTER, R. STORER, G. G. WEINGARTEN and C. WILLIAMSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17886.x

    13. Characterization of Tannins Containing Anti-HIV Activity (pages 542–544)

      R. E. KILKUSKIE, Y.-C. CHENG, K.-H. LEE, G. NONAKA, I. NISHIOKA, M. NISHIZAWA, T. YAMAGISHI, G. E. DUTSCHMAN and A. J. BODNER

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17889.x

    14. Effect of Membrane-Active Ether Lipid (EL) Analogues on Human Immunodeficiency Virus Production Measured by Plaque Assay (pages 545–548)

      LOUIS S. KUCERA, NATHAN IYER, EVA S. LEAKE, ADAM RABEN, LARRY W. DANIEL, EDWARD J. MODEST and CLAUDE PIANTADOSI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17890.x

    15. Improved Clinical Evaluation of Prospective Vaccines and New Therapies against AIDS (pages 549–551)

      VADIM I. KVITASH and ROBERT M. SCHMIDT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17891.x

    16. Synthetic Inhibitors of HIV-1 Protease Block Processing of Pr55gag and Pr160gag-po1 Polyproteins in Infected T Lymphocytes (pages 552–555)

      D. M. LAMBERT, T. D. MEEK, G. B. DREYER, T. K. HART, T. J. MATTHEWS, J. J. LEARY, P. J. BUGELSKI, B. W. METCALF and S. R. PETTEWAY JR.

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17892.x

    17. Hypericin as an Antiretroviral Agent : Mode of Action and Related Analogues (pages 556–562)

      GAD LAVIE, YEHUDA MAZUR, DAVID LAVIE, BRANDI LEVIN, YITZHAK ITTAH and DANIEL MERUELO

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17893.x

    18. Stable Transformed Human Cell Lines Exhibiting tat-Directed Expression of Tissue Plasminogen Activator (pages 563–565)

      S. K. MALCOLM, T. W. THAIS, P. A. HEFFERNAN, S. R. JASKUNAS, J. TANG, J. M. COLACINO and B. R. WARREN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17894.x

    19. A Rapid Fluorogenic Assay of HIV Protease Inhibitors (pages 566–568)

      EDMUND MATAYOSHI, GARY WANG, GRANT KRAFFT, DALE KEMPF, LYNN CODACOVI and JOHN ERICKSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17895.x

    20. Sodium Thiophosphonoformate, A Selective HIV RT Inhibitor : Facile Synthesis and Effects in HIV-Infected Cell Culture (pages 569–571)

      C. E. McKENNA, T.-G. YE, J. N. LEVY, T. WEN, J.-P. BONGARTZ, Y.-C. CHENG, M. C. STARNES, A. BODNER and R. KILKUSKIE

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17896.x

    21. Complement-Mediated Enhancement of HIV-1 Infection Reverses the Anti-HIV-1 Activity of Castanospermine (pages 572–574)

      DAVID C. MONTEFIORI, W. EDWARD ROBINSON JR., ANN MODLISZEWSKI and WILLIAM M. MITCHELL

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17897.x

    22. Effect of Imexon on Friend Virus Complex Infection in Rfv-3r/s Genotype-Containing Mice as a Model for AIDS (pages 575–578)

      JOHN D. MORREY, REED P. WARREN, KEVIN M. OKLEBERRY, ROGER A. BURGER, ROBERT W. SIDWELL and MICHAEL A. CHIRIGOS

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17898.x

    23. Structure-Activity Correlations of Pyrimidine and Purine Dideoxynucleosides as Potential Anti-HIV Drugs (pages 579–587)

      MOHAMED NASR, CHARLES LITTERST and JOHN McGOWAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17899.x

    24. Differential Effect of Cyclic Nucleotide Modulators on HIV Replication (pages 588–590)

      MOSTAFA NOKTA and RICHARD POLLARD

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17900.x

    25. Synthesis and Liposome Encapsulation of Antisense Oligonucleotide-Intercalator Conjugates (pages 593–596)

      C. PIDGEON, H. L. WEITH, D. DARBISHIRE-WEITH, M. CUSHMAN, S. R. BYRN, J.-K. CHEN, J. G. STOWELL, K. RAY and D. CARLSON

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17902.x

    26. Development of an in Vitro Human Monocyte-Derived Macrophage-Based System for Drug Screening against HIV-1 (pages 597–598)

      BRUCE POLSKY, PENNY A. BARON, HOWARD E. GENDELMAN, JONATHAN W. M. GOLD, T-C CHOU and DONALD ARMSTRONG

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17903.x

    27. In Vitro Testing of Therapeutics against SIV and HIV : A Comparison (pages 599–604)

      P. R. SAGER, J. C. CRADOCK, C. L. LITTERST, L. N. MARTIN, K. F. SOIKE, M. MURPHEY-CORB, P. A. MARX, C.-C. TSAI, A. FRIDLAND, A. BODNER, L. RESNICK and R. F. SCHINAZI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17904.x

    28. Self-Cleaving RNAs (Ribozymes) as New Modalities for Anti-HIV Therapy (pages 606–609)

      NAVA SARVER, ARNOLD HAMPEL, EDOUARD M. CANTIN, JOHN A. ZAIA, PAIROJ S. CHANG, MARGARET I. JOHNSTON, JOHN McGOWAN and JOHN J. ROSSI

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17905.x

    29. NIH/NIAID-WHO AIDS Research and Reference Reagent Program (page 610)

      S. STERN, L. MUUL and G. MILMAN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17906.x

    30. Computerized Probe Analysis of the Energetically Favored Binding Sites of an Aspartyl Protease (pages 611–612)

      KENT D. STEWART and PATRICK K. MARTIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17907.x

    31. Dipyridamole Potentiates the Activity of Zidovudine and Other Dideoxynucleosides against HIV-1 in Cultured Cells (pages 613–616)

      JANOS SZEBENI, SHARON M. WAHL, RAYMOND F. SCHINAZI, MIKULAS POPOVIC, SUZANNE GARTNER, LARRY M. WAHL, OWEN S. WEISLOW, GURUPADAPPA BETAGERI, ROBERT L. FINE, JOHN E. DAHLBERG, EDWARD HUNTER and JOHN N. WEINSTEIN

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17908.x

    32. Fluorogenic Determination of Structural Requirements for HIV Protease Substrates (pages 617–619)

      GARY T. WANG, EDMUND MATAYOSHI, JOHN W. ERICKSON and GRANT A. KRAFFT

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17909.x

    33. The Cellular Metabolism of AzdU : Correlation with in Vitro Anti-HIV and Cytotoxic Activities (pages 620–623)

      G. J. WILLIAMS, C. B. COLBY, R. F. SCHINAZI, J-P. SOMMADOSSI, C. K. CHU, D. G. JOHNS and H. MITSUYA

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17910.x

    34. Computer-Assisted Design of Antiviral Agents Directed against Human Immunodeficiency Virus Reverse Transcriptase as Their Target (pages 624–630)

      JANARDAN YADAV, PREM NARAYAN YADAV, SWAMY LAXMINARAYAN, LESLIE MICHELSON, EDWARD ARNOLD and MUKUND J. MODAK

      Article first published online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1990.tb17911.x

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