Annals of the New York Academy of Sciences

Cover image for Annals of the New York Academy of Sciences

February 1991

Volume 618 Temporal Control of Drug Delivery

Pages xi–xvii, 1–626

  1. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. New Clock Mutations in Drosophila (pages 1–10)

      AMITA SEHGAL, BERNICE MAN, JEFFREY L. PRICE, LESLIE B. VOSSHALL and MICHAEL W. YOUNG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27233.x

    2. Physiological Implications of Pulsatile Hormone Secretion (pages 28–37)

      DAVID R. MATTHEWS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27235.x

  2. Part II. Circadian Pharmacodynamics

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Concepts of Circadian Chronopharmacology (pages 102–115)

      ALAIN E. REINBERG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27239.x

    2. Chronophysiologic Determinants of Asthma (pages 123–139)

      GILBERT E. D'ALONZO and MICHAEL H. SMOLENSKY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27241.x

    3. Physiological Factors in Drug Absorption (pages 140–149)

      S. S. DAVIS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27242.x

    4. Circadian Dynamics of Coagulation and Chronopathology of Cardiovascular and Cerebrovascular Events : Future Therapeutic Implications for the Treatment of These Disorders? (pages 159–165)

      H. DECOUSUS, C. BOISSIER, B. PERPOINT, Y. PAGE, P. MISMETTI, S. LAPORTE, B. TARDY and P. QUENEAU

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27244.x

  3. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. The Potential of Using the Natural Rhythmicity of Cell Proliferation in Improving Cancer Chemotherapy in Rodents (pages 182–227)

      LAWRENCE E. SCHEVING, TIEN H. TSAI, LAWRENCE A. SCHEVING and RITCHIE J. FEUERS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27246.x

    2. Circadian and Ultradian Cytokinetic Rhythms of Spontaneous Human Cancer (pages 257–276)

      ROBERT R. KLEVECZ and PATRICIA S. BRALY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27248.x

    3. The Effect of Surgical Timing within the Fertility Cycle on Breast Cancer Outcome (pages 277–291)

      AVRUM BLUMING and WILLIAM J. M. HRUSHESKY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27249.x

    4. When Should the Immune Clock Be Reset? : From Circadian Pharmacodynamics to Temporally Optimized Drug Delivery (pages 312–329)

      FRANCIS LÉVI, CHANTAL CANON, MARIO DIPALMA, IRÈNE FLORENTIN and JEAN-LOUIS MISSET

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27251.x

  4. Part IV. Drug Carriers and Drug Delivery Patterning in Time

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Real Time Response Polymeric Delivery Systems (pages 330–334)

      ROBERT LANGER and JOSEPH KOST

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27252.x

    2. Pharmacokinetic Aspects of Arterial Fluoropyrimidine Delivery (pages 345–349)

      JERRY M. COLLINS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27254.x

    3. Biochemical Basis for Circadian-Dependent Metabolism of Fluoropyrimidines (pages 350–361)

      GEORGE C. DAHER, BARRY E. HARRIS, ELLEN M. WILLARD and ROBERT B. DIASIO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27255.x

    4. Signal-Sensitive Release of Contents from Liposomes Bearing Surface-Grafted Polyelectrolyte Chains (pages 362–366)

      MIZUO MAEDA, ATSUSHI KUMANO and DAVID A. TIRRELL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27256.x

    5. Penetration of Tumor Tissue by Antibodies and Other Immunoproteins (pages 367–382)

      TY R. SHOCKLEY, KE LIN, JANICE A. NAGY, RONALD G. TOMPKINS, HAROLD F. DVORAK and MARTIN L. YARMUSH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27257.x

    6. Antibody-Targeted Photolysis : Bacteriocidal Effects of Sn (IV) Chlorin e6-Dextran-Monoclonal Antibody Conjugates (pages 383–393)

      JOSEPH S. FRIEDBERG, RONALD G. TOMPKINS, SCOTT L. RAKESTRAW, STEPHEN W. WARREN, ALAN J. FISCHMAN and MARTIN L. YARMUSH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27258.x

    7. Drug Delivery by Genetically Engineered Cell Implants (pages 394–404)

      JAMES A. ZWIEBEL, SCOTT M. FREEMAN, KURT NEWMAN, DAVID DICHEK, UNA S. RYAN and W. FRENCH ANDERSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27259.x

  5. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Overview and Evolution of Therapeutic Systems (pages 405–421)

      ALEJANDRO ZAFFARONI

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27260.x

    2. Temporal Control of Drugs : An Engineering Perspective (pages 422–427)

      EARL E. BAKKEN and KENNETH HERUTH

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27261.x

    3. Systems for Triggered, Pulsed, and Programmed Drug Delivery (pages 428–440)

      F. THEEUWES, S. I. YUM, R. HAAK and P. WONG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27262.x

    4. Electronic Control of Iontophoretic Drug Delivery (pages 450–464)

      GARY A. LATTIN, RAMA V. PADMANABHAN and J. BRADLEY PHIPPS

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27264.x

  6. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Investigative Protocols for Chronotherapeutics : Basic Requirements and Illustrative Case Histories (pages 465–483)

      MICHAEL H. SMOLENSKY and GILBERT E. D'ALONZO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27265.x

  7. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Drug Industry and Chronobiology : Achievements and Prospects (pages 484–489)

      AGOSTINO CARANDENTE and FRANZ HALBERG

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27266.x

    2. Successful Drug-Specific Chronotherapy with the H2 Blocker Famotidine in the Symptomatic Relief of Gastroesophageal Reflux Disease (page 517)

      THOMAS J. HUMPHRIES, JANET K. ROOT and KAREN HUFNAGEL

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27269.x

    3. Receptor Dynamics as Applied to the Delivery of Sex Steriods (pages 518–521)

      DAVID H. UPMALIS, MARVIN E. JAFFE and ROBERT F. CASPER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27270.x

  8. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Ambulatory Pumps (pages 544–547)

      WILLIAM G. WEBSTER

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27273.x

    2. Pulsatile Delivery Systems (pages 548–557)

      GEORGE W. CREASY and MARVIN E. JAFFE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27274.x

    3. Chronobiology : Suggestions for Integrating It into Drug Development (pages 563–571)

      JOHN G. HARTER and CARL C. PECK

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27276.x

  9. Poster Papers

    1. Top of page
    2. Part I. High Frequency Domain: Physiologic Requirement for Pulsatile Delivery
    3. Part II. Circadian Pharmacodynamics
    4. Part III. Circadian Dependence of Anticancer Drug Therapeutic Index
    5. Part IV. Drug Carriers and Drug Delivery Patterning in Time
    6. Part V. Complex Single or Multiple Agent Programmable Open- and Closed-Looped Delivery Systems
    7. Part VI. Panel Discussion, Practical Chronotherapeutics: Opportunities and Concerns
    8. Panel A: Successful Chronotherapeutics (Drug-Specific Chronotherapy)
    9. Panel B: Successful Chronotherapeutics (Drug-Independent Approaches)
    10. Poster Papers
    1. Praziquantel as Prophylactic in Schistosomiasis : Formulation and Stability Evaluation of a Liposomal Delivery System (pages 572–574)

      MOSTAFA AKBARIEH, RASHAD TAWASHI, MAMDOUH GHORAB and MAHFOUZ KASSEM

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27277.x

    2. Performance Evaluation of the Molluscicide Activity of Controlled-Release Niclosamide from a Porous Delivery System (pages 575–577)

      MOSTAFA AKBARIEH, RASHAD TAWASHI, MOHSEM SOLIMAN, EMAN EL-LEITHY and MAHFOUZ KASSEM

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27278.x

    3. Egalet®, a Novel Controlled-Release System (pages 578–580)

      DANIEL BAR-SHALOM, NIELS BUKH and TURE KINDT LARSEN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27279.x

    4. Novel Controlled Release Pellets Containing Morphine Sulfate (pages 581–583)

      R. S. COOK, A. G. COUTTS, K. GILL and G. SIMPKIN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27280.x

    5. Pharmacokinetic Study of a Novel Amphotericin B Colloidal Dispersion with Improved Therapeutic Index (pages 586–588)

      LUKE S. S. GUO, ROBERT M. FIELDING and DANIEL MUFSON

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27282.x

    6. Transdermal Delivery of Insulin by Iontophoresis (pages 596–598)

      YING SUN and HONG XUE

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27285.x

    7. Temporal Variation in Postsurgical Utilization of Morphine Sulfate via Patient-Controlled Analgesia (pages 599–601)

      S. E. AUVIL-NOVAK, R. D. NOVAK, M. H. SMOLENSKY, M. MORRIS and J. W. KWAN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27286.x

    8. Hidden Variables in Drug-Delivery Systems (page 604)

      ALEXANDER P. DUBROV

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27288.x

    9. Circadian Stage Dependent Variation of Cortisol Related to DNA Synthesis in Human Bone Marrow (pages 605–609)

      RUNE SMAALAND, KNUT LOTE, OLAV SLETVOLD, ROBBERT BJERKNES, ASBJORN AAKVAAG, STEIN E. VOLLSET and OLE D. LAERUM

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27289.x

    10. Evidence for Circadian Dependency of Recombinant Human Erythropoietin (rhEPO) Response in the Mouse (pages 610–612)

      PATRICIA A. WOOD, S. SÁNCHEZ DE LA PEN̄A and WILLIAM J. M. HRUSHESKY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27290.x

    11. Differential Temporal Kinetics of Atropine at Central Nervous System versus Cardiac Effect Sites (pages 613–614)

      EVERETT H. ELLINWOOD JR., SAMIR K. GUPTA and ARLENE M. NIKAIDO

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27291.x

    12. Pharmacokinetic Consequences of Spaceflight (pages 615–618)

      LAKSHMI PUTCHA and NITZA M. CINTRÓN

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27292.x

    13. Murine Cardiovascular Function during Pregnancy : The Fetus and Placenta as a Closed-Loop Drug-Delivery System (pages 619–622)

      SALVADOR SÁNCHEZ DE LA PEN̄A, SILVIA AZAR and WILLIAM J. M. HRUSHESKY

      Version of Record online: 17 DEC 2006 | DOI: 10.1111/j.1749-6632.1991.tb27293.x

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